Lunit Announces Collaboration with 10x Genomics to Integrate AI-Enabled Pathology Analysis with Spatial Molecular Data for Oncology Clinical Research
Lunit’s AI pathology platform will be integrated into 10x Genomics’ spatial biology workflow to enhance oncology biomarker research.
Rhea-AI Summary
Lunit and 10x Genomics (TXG) are collaborating to integrate Lunit's AI-enabled H&E pathology analysis with 10x Genomics' spatial molecular technologies for oncology clinical research. Lunit SCOPE IO will be incorporated into 10x's oncology biomarker discovery workflow to analyze Hematoxylin and Eosin pathology images alongside spatial molecular data from 10x's Xenium and Atera platforms.
The combined approach is intended to help researchers relate tissue morphology to tumor biology and identify biomarkers linked to treatment response and resistance. Initial work will support oncology clinical research studies focused on antibody-drug conjugates and immunotherapy response prediction, as part of 10x's broader effort to explore potential future diagnostic applications of spatial technologies in oncology. Lunit SCOPE IO, which is for research use only, characterizes tumor and stromal regions, immune-cell distribution, tertiary lymphoid structures and other tumor microenvironment features to complement molecular profiling.
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Historical Context
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Cleveland Clinic collaboration targeted biomarkers for antibody-drug conjugate and immunotherapy response
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Lausanne collaboration advanced spatial technology applications for cancer diagnostic research
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Key Terms
hematoxylin and eosin medical
deep learning technical
tumor microenvironment medical
antibody-drug conjugates medical
spatial molecular data technical
AI-generated analysis. How Rhea-AI works. Not financial advice.
10x Genomics, a leader in single-cell and spatial biology, to combine its spatial biology technologies with Lunit's AI-powered H&E pathology analysis to advance oncology biomarker discovery
10x Genomics is a leader in single cell and spatial biology, with its technologies cited in more than 10,000 research publications and enabling discoveries across oncology, immunology, neuroscience and other fields.
The work brings together molecular insights generated using 10x's Xenium and Atera spatial platforms with tissue characterization from Lunit SCOPE IO. By analyzing pathology images alongside spatial molecular data, 10x aims to better understand how tissue morphology relates to the underlying biology of tumors and identify biomarkers associated with treatment response and resistance.
"10x Genomics has built powerful tools for understanding the molecular organization of tissue," said Brandon Suh, CEO of Lunit. "Lunit SCOPE IO adds the ability to analyze the full H&E landscape at scale. Together, we believe these technologies can help researchers connect deep molecular insight with the tissue patterns that pathologists recognize every day."
"Spatial technologies provide a fundamentally richer view of the biology within tumors and their microenvironment," said Roman Yelensky, Vice President, Clinical Applications of 10x Genomics. "By combining that molecular depth with Lunit's AI-based analysis of the same H&E images pathologists work with every day, we can give researchers a more complete view of the tumor to accelerate the discovery of biomarkers that could inform treatment strategies and enable potential future diagnostic development."
The work will initially support oncology clinical research studies focused on antibody-drug conjugates and immunotherapy response prediction. These studies are part of 10x's broader effort to explore potential future diagnostic applications of spatial technologies in oncology.
Lunit SCOPE IO uses deep learning to analyze whole-slide H&E pathology images and characterize tissue features including tumor and stromal regions, immune-cell distribution, tertiary lymphoid structures and other features of the tumor microenvironment. Used alongside 10x's spatial technologies, these analyses provide additional tissue context that complements molecular profiling in oncology clinical research.
* Lunit SCOPE IO is for research use only. Not for use in diagnostic procedures.
About Lunit
Founded in 2013, Lunit (KRX: 328130) is a global leader on a mission to conquer cancer through AI. Our clinically validated solutions span medical imaging, breast health, and biomarker analysis, empowering earlier detection, smarter treatment decisions, and more precise outcomes across the cancer care continuum.
Lunit offers a comprehensive suite spanning risk prediction and early detection to precision oncology. Our FDA-cleared Lunit INSIGHT Breast Suite and breast health solutions support cancer screening in thousands of medical institutions worldwide, while the Lunit SCOPE platform is used in research partnership with global pharma and laboratory leaders for biomarker research, and companion diagnostic development.
Trusted by over 10,000 sites in more than 65 countries, Lunit combines deep medical expertise with continuously evolving datasets to deliver measurable impact for patients, clinicians, and researchers alike. Headquartered in
About 10x Genomics
10x Genomics is a life science technology company building products to accelerate the mastery of biology and advance human health. Our integrated research solutions include instruments, consumables and software for single cell and spatial biology, which help academic and translational researchers and biopharmaceutical companies understand biological systems at a resolution and scale that matches the complexity of biology. Our products are behind breakthroughs in oncology, immunology, neuroscience and more, fueling powerful discoveries that are transforming the world's understanding of health and disease. To learn more, visit 10xgenomics.com or connect with us on LinkedIn, X, Facebook, Bluesky or YouTube.
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FAQ
What is Lunit SCOPE IO and how is it used in this collaboration?
Lunit SCOPE IO is an AI-powered pathology platform that uses deep learning to analyze whole-slide Hematoxylin and Eosin (H&E) pathology images. It characterizes tissue features such as tumor and stromal regions, immune-cell distribution, tertiary lymphoid structures and other aspects of the tumor microenvironment. In this collaboration, it is incorporated into 10x Genomics' oncology biomarker discovery workflow and used alongside spatial molecular data from 10x's platforms to provide additional tissue context for oncology clinical research.
Which 10x Genomics technologies will be combined with Lunit’s AI pathology analysis?
The collaboration combines molecular insights from 10x Genomics' Xenium and Atera spatial platforms with tissue characterization from Lunit SCOPE IO. Pathology images analyzed by Lunit's AI are evaluated together with spatial molecular data generated by these 10x technologies in oncology-focused clinical research studies.
What types of oncology studies will be initially supported by this work?
The initial work will support oncology clinical research studies focused on antibody-drug conjugates and immunotherapy response prediction. These studies are described as part of 10x Genomics' broader effort to explore potential future diagnostic applications of spatial technologies in oncology.
Is Lunit SCOPE IO intended for clinical diagnostic use in this collaboration?
No. Lunit SCOPE IO is stated to be for research use only and not for use in diagnostic procedures. Its role in this collaboration is to support oncology clinical research by providing AI-based analysis of H&E pathology images that complements spatial molecular profiling.