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Top Stock Gainers April 2025 - Monthly Performance Ranked

The top US-listed stocks of April 2025 by monthly gain, on split-adjusted closes. Ranks 4,154 companies above $100M on NYSE, Nasdaq and NYSE American.

Looking for intraday moves instead? Today's stock movers ranks the current session's alert board, so it measures against whichever session is running rather than covering a fixed window.

2025
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec

April 2025 ranking, complete through April 30, 2025

The same month on news: the biggest gains on news in April 2025 and the biggest drops, each ranked by the move on the day its story landed.

2 stocks are withheld from this ranking because their price history is under review.

The gain covers the period; price, market cap, sector and country show each company as it is today.

Swipe or scroll the table sideways for more columns.

Rank
Symbol
Company Name
Apr Gain
Market Cap (today)
Price (today)
Country
Sector
1
CEP
Cantor Equity Partners, Inc.
+291.91%
$223.51M
$21.70
United States
Financial Services
2
PNBK
Patriot National Bancorp Inc
+240.08%
$115.18M
$0.9700
United States
Financial Services
3
AREC
AMERICAN RESOURCES CORP
+122.93%
$217.15M
$2.03
United States
Industrials
4
THTX
Theratechnologies Inc.
+102.86%
$150.81M
$3.28
Canada
Healthcare
5
TOI
The Oncology Institute, Inc.
+96.83%
$512.91M
$5.13
United States
Healthcare
6
ENGS
Energys Group Limited
+90.30%
$126.90M
$2.85
United Kingdom
Industrials
7
TMC
TMC the metals company Inc.
+89.16%
$2.39B
$4.22
Canada
Basic Materials
8
BSGM
BioSig Technologies, Inc.
+85.59%
$215.15M
$6.10
United States
Healthcare
9
HTZ
Hertz Global Holdings, Inc
+83.33%
$659.44M
$1.85
United States
Industrials
10
TDUP
ThredUp Inc.
+82.52%
$313.23M
$2.38
United States
Consumer Cyclical
11
AGEN
Agenus Inc.
+80.63%
$392.91M
$8.70
United States
Healthcare
12
ANTE
AirNet Technology Inc.
+79.26%
$546.93M
$4.94
China
Communication Services
13
RZLV
Rezolve AI PLC
+77.69%
$937.24M
$2.35
United Kingdom
Technology
14
STRO
Sutro Biopharma, Inc.
+76.38%
$266.13M
$16.05
United States
Healthcare
15
MIST
Milestone Pharmaceuticals Inc.
+73.68%
$114.66M
$0.9210
Canada
Healthcare
16
ICAD
Icad Inc
+72.73%
$106.31M
$3.87
United States
Healthcare
17
GPCR
Structure Therapeutics Inc.
+70.99%
$2.63B
$36.91
United States
Healthcare
18
KOD
Kodiak Sciences Inc
+70.31%
$2.12B
$33.80
United States
Healthcare
19
FRGE
Forge Global Holdings, Inc.
+69.33%
$623.01M
$45.00
United States
Financial Services
20
FATE
Fate Therapeutics, Inc.
+69.07%
$309.14M
$2.58
United States
Healthcare
21
ABAT
American Battery Technology Company
+67.65%
$340.76M
$2.39
United States
Industrials
22
USAR
USA Rare Earth, Inc.
+67.36%
$6.10B
$16.25
United States
Basic Materials
23
SES
SES AI Corporation
+63.60%
$196.56M
$0.5294
United States
Consumer Cyclical
24
IFRX
InflaRx N.V.
+61.90%
$306.53M
$2.08
Germany
Healthcare
25
XGN
Exagen Inc.
+58.52%
$208.46M
$8.61
United States
Healthcare
26
LXRX
Lexicon Pharmaceuticals, Inc.
+57.47%
$970.00M
$2.18
United States
Healthcare
27
STOK
Stoke Therapeutics, Inc.
+56.66%
$1.83B
$28.35
United States
Healthcare
28
NGNE
Neurogene, Inc.
+55.36%
$672.38M
$33.60
United States
Healthcare
29
GSIT
GSI Technology
+54.81%
$225.21M
$5.86
United States
Technology
30
SLGL
Sol-Gel Technologies Ltd.
+54.69%
$202.23M
$61.77
Israel
Healthcare
31
OLMA
Olema Pharmaceuticals, Inc.
+54.49%
$843.48M
$9.64
United States
Healthcare
32
NUTX
Nutex Health Inc.
+54.02%
$1.43B
$208.82
United States
Healthcare
33
THRD
Third Harmonic Bio, Inc.
+53.87%
$242.79M
$5.38
United States
Healthcare
34
TSHA
Taysha Gene Therapies, Inc.
+53.36%
$1.65B
$5.07
United States
Healthcare
35
AMLX
Amylyx Pharmaceuticals, Inc.
+52.99%
$4.21B
$33.00
United States
Healthcare
36
MBX
MBX Biosciences, Inc.
+52.92%
$2.98B
$61.98
United States
Healthcare
37
SLN
Silence Therapeutics Plc
+52.89%
$750.20M
$12.07
United Kingdom
Healthcare
38
GYRE
Gyre Therapeutics, Inc.
+52.26%
$794.19M
$7.49
United States
Healthcare
39
CRMD
CorMedix Inc.
+51.40%
$606.41M
$7.78
United States
Healthcare
40
KROS
Keros Therapeutics, Inc.
+51.20%
$232.57M
$11.73
United States
Healthcare
41
NVFY
Nova Lifestyle, Inc.
+51.11%
$115.31M
$4.95
United States
Consumer Cyclical
42
ROMA
Roma Green Finance Limited
+50.64%
$536.08M
$9.00
Hong Kong
Industrials
43
QURE
uniQure N.V.
+48.94%
$3.13B
$45.17
Netherlands
Healthcare
44
ALMU
Aeluma, Inc.
+48.51%
$267.79M
$13.90
United States
Technology
45
CRBP
Corbus Pharmaceuticals Holdings, Inc.
+48.51%
$152.31M
$7.88
United States
Healthcare
46
NEOV
NeoVolta Inc.
+47.79%
$197.78M
$3.36
United States
Industrials
47
ABEO
Abeona Therapeutics Inc.
+47.42%
$332.81M
$5.82
United States
Healthcare
48
CMP
Compass Minerals International, Inc.
+47.37%
$999.14M
$23.80
United States
Basic Materials
49
EDIT
Editas Medicine, Inc.
+46.02%
$448.45M
$2.92
United States
Healthcare
50
AVR
Anteris Technologies Global Corp.
+45.59%
$792.34M
$8.13
Australia
Healthcare
51
EVLV
Evolv Technologies Holdings, Inc.
+44.88%
$883.17M
$4.91
United States
Industrials
52
YALA
Yalla Group Limited
+43.90%
$835.06M
$5.50
United Arab Emirates
Technology
53
POWW
Outdoor Holding Company
+43.80%
$275.06M
$2.37
United States
Industrials
54
SEZL
Sezzle Inc.
+42.96%
$3.67B
$108.93
United States
Financial Services
55
UAMY
United States Antimony Corporation
+42.67%
$693.72M
$4.63
United States
Basic Materials
56
CMPS
COMPASS Pathways Plc
+42.65%
$2.05B
$14.78
United Kingdom
Healthcare
57
SLP
Simulations Plus, Inc.
+42.53%
$372.54M
$18.42
United States
Healthcare
58
MGNX
MacroGenics, Inc.
+42.21%
$262.44M
$4.12
United States
Healthcare
59
SLS
SELLAS Life Sciences Group, Inc.
+42.20%
$2.40B
$11.88
United States
Healthcare
60
RGNX
REGENXBIO Inc.
+42.16%
$536.03M
$8.12
United States
Healthcare
61
SLE
Super League Enterprise, Inc.
+41.99%
$257.45M
$5.53
United States
Communication Services
62
NG
NovaGold Resources Inc.
+41.95%
$3.41B
$7.77
Canada
Basic Materials
63
CTGO
Contango Silver & Gold Inc.
+41.31%
$662.79M
$19.82
United States
Basic Materials
64
HCSG
Healthcare Services Group
+41.11%
$1.48B
$21.57
United States
Healthcare
65
CERT
Certara, Inc.
+40.43%
$1.35B
$8.83
United States
Healthcare
66
IMNM
Immunome, Inc.
+40.42%
$2.92B
$25.75
United States
Healthcare
67
HLVX
HilleVax, Inc.
+40.07%
$104.76M
$2.09
United States
Healthcare
68
PLTR
Palantir Technologies Inc.
+39.87%
$444.54B
$184.99
United States
Technology
69
FULC
Fulcrum Therapeutics, Inc.
+39.49%
$292.98M
$3.84
United States
Healthcare
70
DBVT
DBV Technologies S.A.
+39.47%
$793.78M
$12.63
France
Healthcare
71
SEPN
Septerna, Inc.
+38.65%
$1.84B
$39.31
United States
Healthcare
72
ITRG
Integra Resources Corp.
+38.52%
$584.27M
$2.88
Canada
Basic Materials
73
UPB
Upstream Bio, Inc.
+38.21%
$297.41M
$5.43
United States
Healthcare
74
SABS
SAB Biotherapeutics, Inc.
+38.19%
$323.00M
$3.55
United States
Healthcare
75
GRAL
GRAIL, Inc.
+37.43%
$4.85B
$108.52
United States
Healthcare
76
SLSR
Solaris Resources Inc.
+37.35%
$1.24B
$7.44
Switzerland
Basic Materials
77
VERV
Verve Therapeutics, Inc.
+37.12%
$994.04M
$11.13
United States
Healthcare
78
PPTA
Perpetua Resources Corp.
+36.90%
$3.10B
$24.76
United States
Basic Materials
79
ARVN
Arvinas, Inc
+36.84%
$549.08M
$8.51
United States
Healthcare
80
SVV
Savers Value Village, Inc.
+36.61%
$1.39B
$9.09
United States
Consumer Cyclical
81
ODD
ODDITY Tech Ltd.
+36.47%
$866.22M
$18.78
Israel
Consumer Defensive
82
MTC
MMTec, Inc.
+36.36%
$600.51M
$6.03
Hong Kong
Financial Services
83
IDYA
IDEAYA Biosciences, Inc.
+36.29%
$3.83B
$39.71
United States
Healthcare
84
SDGR
Schrodinger, Inc.
+36.04%
$2.26B
$30.20
United States
Healthcare
85
ARCT
Arcturus Therapeutics Holdings Inc.
+35.84%
$408.72M
$14.38
United States
Healthcare
86
KYMR
Kymera Therapeutics, Inc.
+35.80%
$10.04B
$122.06
United States
Healthcare
87
LFMD
LifeMD, Inc.
+35.54%
$159.06M
$3.30
United States
Healthcare
88
DNLI
Denali Therapeutics Inc.
+35.48%
$3.45B
$21.60
United States
Healthcare
89
CGC
Canopy Growth Corporation
+35.29%
$434.56M
$0.9672
Canada
Healthcare
90
THAR
Tharimmune, Inc.
+35.16%
$187.37M
$4.74
United States
Healthcare
91
EYPT
EyePoint, Inc.
+35.05%
$341.23M
$4.07
United States
Healthcare
92
RLAY
Relay Therapeutics, Inc.
+34.82%
$4.17B
$19.03
United States
Healthcare
93
DSGN
Design Therapeutics, Inc.
+34.81%
$823.57M
$13.16
United States
Healthcare
94
TMDX
TransMedics Group, Inc.
+34.77%
$3.06B
$88.27
United States
Healthcare
95
RPTX
Repare Therapeutics Inc.
+34.31%
$114.24M
$2.65
Canada
Healthcare
96
CAPR
Capricor Therapeutics Inc
+34.04%
$543.02M
$9.34
United States
Healthcare
97
AARD
Aardvark Therapeutics, Inc.
+34.02%
$125.84M
$5.75
United States
Healthcare
98
SGMT
Sagimet Biosciences Inc. Series A
+33.72%
$689.96M
$11.10
United States
Healthcare
99
MASS
908 Devices Inc.
+33.42%
$462.11M
$11.18
United States
Healthcare
100
KOPN
Kopin Corp
+33.33%
$918.21M
$4.94
United States
Technology
S&P 500 fund (SPY) -1.15%
Finished higher 39% of 4,154
Median move -2.0%
Leading sector Healthcare +3.6% median
Lagging sector Energy -14.0% median

Over April 2025, 39% of the 4,154 ranked companies finished higher and the median move was -2.0%; Healthcare led on median (+3.6%) and Energy lagged (-14.0%). The S&P 500 fund (SPY) moved -1.15% between its Apr 1, 2025 and Apr 30, 2025 closes. Each ranked company's gain runs from its own first close inside the period, so a company listed later in the period is measured over a shorter window.

Top gain on this page +291.91% CEP
Rows on this page 100 ranks 1–100
Page 1 of 42
Period April 2025 closed

Best performing large-cap stocks in April 2025

PLTR Palantir Technologies Inc. +39.87% $444.54B
KYMR Kymera Therapeutics, Inc. +35.80% $10.04B
STRL Sterling Infrastructure, Inc. +29.22% $15.62B
SMMT Summit Therapeutics Inc. +28.30% $13.58B
MSTR Strategy Inc +24.21% $66.48B

April 2025 Stock Market Momentum

This page answers a current-month trend question with data: which US-listed stocks have shown the strongest price gains so far in April 2025. The ranking is based on observed market performance, not analyst ratings, price targets, or investment recommendations.

Use the list to research momentum, market breadth, sector strength, and catalysts behind large moves. Before acting on any stock, review the company's news, SEC filings, liquidity, volatility, and your own risk constraints.

Looking for a specific Symbol?
#1 CEP leads with +292% April 2025

Among the 4,154 NYSE, Nasdaq and NYSE American stocks currently eligible for this ranking, CEP (Cantor Equity Partners, Inc.) has the highest gain in April 2025 with +292%. Following are PNBK (+240%) and AREC (+123%). Top performing sectors: Financial Services (+136% avg, 2 in top 10), Industrials (+69% avg, 3 in top 10), Communication Services (+61% avg).

MARKET LEADERS
52-WEEK LEADER
MGRT +2509%
Mega Fortune Company L..
2025 YTD LEADER
QMMM +8744%
QMMM Holdings Limited
APR 2025 LEADER
CEP +292%
Cantor Equity Partners..
52-Week Top 5 Full List →
1 MGRT +2508.7% 2 SNDK +1826.6% 3 AXTI +1436.4% 4 ANL +784.8% 5 MTC +695.4%
2025 YTD Top 5 Full List →
1 QMMM +8744.4% 2 ABVX +1749.9% 3 SRM +1460.6% 4 TOI +1113.4% 5 RLMD +973.1%
April 2025 Top 5 Full List →
1 CEP +291.9% 2 PNBK +240.1% 3 AREC +122.9% 4 THTX +102.9% 5 TOI +96.8%
Quick Access: 52-Week 2025 YTD Apr 2025 Market Cap Dividends

This ranking shows the top performing stocks and biggest stock gainers during April 2025, calculated from the first to the last trading day of the month. It shows which stocks are going up this month, with split-adjusted data used for consistent performance calculations.

Monthly performance rankings can reveal price strength, sustained momentum, sector rotation, and event-driven moves that are not visible in one-day movers lists. The table is informational only and does not recommend any stock to buy, sell, or hold.

Gains are computed on split-adjusted closes, so a split inside the month does not read as a move. This ranking is informational and is not investment advice.
What this ranking covers
Universe
US-listed companies on NYSE, Nasdaq and NYSE American.
Floors
Market cap of at least $100 million, and one close inside the month to measure from.
Exclusions
Stocks whose price history is under review are withheld, and their count is stated above.
Measured on
Split-adjusted closes, from the first close inside the month to the last one in it.
Refreshed
Rebuilt once the session behind those closes has settled. The date above the table names that session, not the moment the table was written.

Frequently Asked Questions

Q Which stock has gained the most in April 2025?
A

CEP (Cantor Equity Partners, Inc.) has the highest monthly gain in this ranking for April 2025, with a gain of 292%. Top performers this month include CEP, PNBK, AREC.

Q What stocks gained the most in April 2025?
A

The biggest gainers in April 2025 were: CEP (+292%), PNBK (+240%), AREC (+123%), THTX (+103%), TOI (+97%). These monthly rankings show which stocks had the strongest short-term momentum.

Q Does this page recommend the best stocks to buy now?
A

No. This page is an informational ranking of stocks that have already gone up during April 2025. It does not make buy, sell, or hold recommendations and should be used as a research starting point, not financial advice.

Q How can this ranking help explain current stock market trends?
A

The ranking shows where price strength is concentrated during April 2025. Comparing the top gainers by sector, market cap, and recent catalysts can help identify momentum themes and market rotation without implying that any listed stock is a recommendation.

Q Which companies does this ranking include?
A

4,154 companies with a market capitalization above $100 million traded on NYSE, Nasdaq and NYSE American, each with at least one trading day inside April 2025. One close inside the month is enough to qualify, so a company that listed during the month is ranked on the part of it that it traded.

Q Which sectors performed best in April 2025?
A

The five highest-gaining companies in April 2025 sit in Financial Services, Industrials, Healthcare, with the leader CEP in Financial Services. That describes the top of this list, not a sector ranking; the market-context strip above the table reports the median move of each sector's ranked companies.

Q How is monthly stock performance calculated?
A

Monthly stock performance is calculated by comparing the closing price on the last trading day of the month to the closing price on its first trading day, both split-adjusted. A company whose trading history begins inside the month is measured from its first close.

Q Where can I find today's top stock gainers and most active stocks?
A

This page ranks stocks by their full-month performance in April 2025. For today's top stock gainers, real-time stock movers, and the most active stocks right now, visit our Momentum Scanner, which tracks live intraday activity across US-listed symbols.

Understanding Monthly Stock Performance

Monthly performance rankings reveal short-term momentum patterns and help identify stocks experiencing rapid price movements:

  • Momentum Research: Stocks showing strong monthly performance can help identify where market attention and price strength are concentrated.
  • Sector Rotation: Monthly rankings can reveal which sectors are gaining favor with investors and where market leadership is shifting.
  • Event-Driven Moves: Earnings releases, product launches, and regulatory approvals often create significant monthly price movements.

Using Monthly Data Effectively

  • Combine Timeframes: Compare monthly gainers with 52-week and YTD performance to identify stocks with both short and long-term momentum.
  • Research the Catalyst: Investigate why top monthly performers moved significantly. The reason for the move matters as much as the percentage gain.
  • Watch for Reversals: Extreme monthly gains sometimes precede corrections, so treat the ranking as a research starting point rather than a buy list.

Evaluate Your Positions

Researching one of this month's top movers? Use our Stock Return Calculator to review historical performance, or the Position Size Calculator to model position sizing and risk before making your own decision.