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MARKET LEADERS
52-WEEK LEADER
BW +3641%
Babcock & Wilcox Enter..
2025 YTD LEADER
RGC +9999%
Regencell Bioscience H..
OCT 2025 LEADER
SPRB +1137%
Spruce Biosciences, Inc.
📈 52-Week Top 5 Full List →
1 BW +3641.0% 2 BE +1209.7% 3 PL +1043.0% 4 WOLF +783.8% 5 AMPX +772.7%
📅 2025 YTD Top 5 Full List →
1 RGC +9999.0% 2 AXTI +3869.9% 3 HYMC +1678.3% 4 ABVX +1491.1% 5 RLMD +1468.5%
🗓 October 2025 Top 5 Full List →
1 SPRB +1137.1% 2 RANI +332.2% 3 PRAX +274.9% 4 NUAI +201.3% 5 SUPV +164.8%
Quick Access: 52-Week 2025 YTD Oct 2025 Market Cap Dividends
#1 SPRB leads with +1,137% October 2025

SPRB (Spruce Biosciences, Inc.) is the best performing stock in October 2025. Following are RANI (+332%) and PRAX (+275%). Top performing sectors: Utilities (+108% avg, 1 in top 10), Financial Services (+103% avg, 1 in top 10), Healthcare (+101% avg, 6 in top 10).

Top Stock Gainers October 2025 - Monthly Performance Ranked

Discover the best stocks of October 2025 ranked by monthly performance. Find which stock gainers delivered the highest gains this month, with market caps over $100 million on Nasdaq and NYSE.
2025
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec

This ranking shows the top performing stocks and biggest stock gainers during October 2025, calculated from the first to the last trading day of the month. See which stocks posted the highest gains this month. Using split-adjusted data ensures accurate performance calculations.

Monthly performance rankings reveal sustained momentum and sector rotation patterns not visible in shorter timeframes. These rapid movers often present opportunities for traders and momentum investors.

Looking for a specific Symbol?

Data as of April 23, 2026 at 6:00 PM EDT

Rank
Symbol
Company Name
Oct Gain
Market Cap
Price
Country
Sector
1
SPRB
Spruce Biosciences, Inc.
1137.08%
141.49 M
$ 52.36
United States
Healthcare
2
RANI
Rani Therapeutics Holdings,...
332.22%
118.66 M
$ 0.95
United States
Healthcare
3
PRAX
Praxis Precision Medicines,...
274.88%
9.39 B
$ 337.29
United States
Healthcare
4
NUAI
New Era Energy & Digital, Inc.
201.33%
405.51 M
$ 4.29
United States
Technology
5
SUPV
Grupo Supervielle S.A.
164.82%
901.61 M
$ 9.54
Argentina
Financial Services
6
DGXX
Digi Power X Inc.
153.36%
246.99 M
$ 3.53
United States
Utilities
7
INBX
Inhibrx Biosciences, Inc.
140.32%
1.68 B
$ 115.09
United States
Healthcare
8
VTYX
Ventyx Biosciences Inc
136.94%
1.00 B
$ 14
United States
Healthcare
9
NVA
Nova Minerals Limited
131.35%
251.67 M
$ 6.39
Australia
Basic Materials
10
REPL
Replimune Group, Inc.
131.12%
187.44 M
$ 2.27
United States
Healthcare
11
CURR
CURRENC Group Inc.
126.35%
242.86 M
$ 3.17
Singapore
Technology
12
GSIT
GSI Technology, Inc.
125.56%
273.21 M
$ 7.55
United States
Technology
13
BMA
Banco Macro S.A.
124.02%
4.96 B
$ 77.64
Argentina
Financial Services
14
GGAL
Grupo Financiero Galicia S.A.
122.04%
7.83 B
$ 46.2
Argentina
Financial Services
15
EDN
Empresa Distribuidora y Com...
121.92%
1.25 B
$ 26.34
Argentina
Utilities
16
PHOE
Phoenix Asia Holdings Limited
109.56%
378.00 M
$ 17.5
Hong Kong
Industrials
17
GLTO
Galecto Inc
107.95%
1.73 B
$ 28.69
Denmark
Healthcare
18
BBAR
Banco BBVA Argentina S.A.
105.58%
3.17 B
$ 15.52
Argentina
Financial Services
19
CEPU
Central Puerto S.A.
100.52%
2.28 B
$ 14.83
Argentina
Utilities
20
NERV
Minerva Neurosciences, Inc.
100%
318.07 M
$ 7.35
United States
Healthcare
21
TMQ
Trilogy Metals Inc.
95.18%
799.46 M
$ 4.6
Canada
Basic Materials
22
NEGG
Newegg Commerce, Inc.
95.14%
917.07 M
$ 43.74
United States
Consumer Cyclical
23
PUMP
ProPetro Holding Corp.
91.16%
1.89 B
$ 15.41
United States
Energy
24
NGNE
Neurogene Inc.
90.6%
425.84 M
$ 27.27
United States
Healthcare
25
LAES
SEALSQ Corp
85.96%
681.69 M
$ 3.06
Switzerland
Technology
26
NVTS
Navitas Semiconductor Corpo...
84.38%
4.26 B
$ 18.47
United States
Technology
27
OPTX
Syntec Optics Holdings, Inc.
84.08%
406.57 M
$ 10.99
United States
Technology
28
VICR
Vicor Corporation
84%
12.02 B
$ 265
United States
Technology
29
GNLX
Genelux Corporation
83.64%
113.81 M
$ 2.54
United States
Healthcare
30
IMMX
Immix Biopharma, Inc.
82.69%
539.66 M
$ 10.18
United States
Healthcare
31
IMDX
Insight Molecular Diagnosti...
82.67%
120.63 M
$ 3.75
United States
Healthcare
32
CRML
Critical Metals Corp.
82.51%
1.50 B
$ 11.86
United States
Basic Materials
33
DYN
Dyne Therapeutics, Inc.
80.64%
3.25 B
$ 19.67
United States
Healthcare
34
OMER
Omeros Corporation
77.05%
962.59 M
$ 13.37
United States
Healthcare
35
GLUE
Monte Rosa Therapeutics, Inc.
71.33%
1.68 B
$ 20.98
United States
Healthcare
36
CELC
Celcuity Inc.
70.63%
5.92 B
$ 122.42
United States
Healthcare
37
NAK
Northern Dynasty Minerals Ltd.
70.34%
1.14 B
$ 2.04
Canada
Basic Materials
38
NMRA
Neumora Therapeutics, Inc.
69.66%
422.01 M
$ 2.31
United States
Healthcare
39
PACB
Pacific Biosciences of Cali...
69.57%
516.42 M
$ 1.71
United States
Healthcare
40
LUMN
Lumen Technologies, Inc.
69.36%
9.54 B
$ 9.26
United States
Communication Services
41
SLDP
Solid Power, Inc.
69.27%
889.10 M
$ 3.96
United States
Consumer Cyclical
42
ATXS
Astria Therapeutics, Inc.
67.51%
718.13 M
$ 12.58
United States
Healthcare
43
HBNB
Hotel101 Global Holdings Corp.
65.96%
1.50 B
$ 6.425
Singapore
Real Estate
44
ARMP
Armata Pharmaceuticals, Inc.
65.93%
509.56 M
$ 13.91
United States
Healthcare
45
HKD
AMTD Digital Inc.
65.73%
543.70 M
$ 1.73
France
Technology
46
VELO
Velo3D, Inc.
65.18%
392.20 M
$ 14.96
United States
Technology
47
ACHV
Achieve Life Sciences, Inc.
65.16%
225.21 M
$ 4.23
United States
Healthcare
48
SNDK
Sandisk Corporation
64.57%
144.51 B
$ 979.07
United States
Technology
49
SABS
SAB Biotherapeutics, Inc.
64.14%
280.40 M
$ 3.99
United States
Healthcare
50
MAMK
MaxsMaking Inc.
63.85%
218.78 M
$ 13.16
China
Industrials
51
EGAN
eGain Corporation
63.12%
218.27 M
$ 7.97
United States
Technology
52
PYXS
Pyxis Oncology, Inc.
62.56%
118.12 M
$ 1.88
United States
Healthcare
53
RNA
Atrium Therapeutics, Inc.
62.44%
211.93 M
$ 13.66
United States
Healthcare
54
ELDN
Eledon Pharmaceuticals, Inc.
62.41%
317.72 M
$ 3.99
United States
Healthcare
55
AXTI
AXT, Inc.
61.91%
4.83 B
$ 86.94
United States
Technology
56
BALY
Bally's Corporation
59.74%
586.01 M
$ 11.92
United States
Consumer Cyclical
57
NAUT
Nautilus Biotechnology, Inc.
59.24%
363.24 M
$ 2.87
United States
Healthcare
58
PALI
Palisade Bio, Inc.
58.02%
392.23 M
$ 2.34
United States
Healthcare
59
CABA
Cabaletta Bio, Inc.
56.28%
352.89 M
$ 3.17
United States
Healthcare
60
REKR
Rekor Systems, Inc.
56.17%
125.90 M
$ 0.9218
United States
Technology
61
AMD
Advanced Micro Devices, Inc.
56.16%
494.76 B
$ 303.46
United States
Technology
62
FLNC
Fluence Energy, Inc.
56.13%
2.48 B
$ 13.5
United States
Utilities
63
TSHA
Taysha Gene Therapies, Inc.
55.97%
1.93 B
$ 6.72
United States
Healthcare
64
SKYX
SKYX Platforms Corp.
55.75%
146.87 M
$ 1.1
United States
Industrials
65
TE
T1 Energy Inc.
55.65%
1.50 B
$ 5.39
United States
Industrials
66
BNR
Burning Rock Biotech Limited
55.25%
224.59 M
$ 20.86
China
Healthcare
67
YPF
YPF Sociedad Anónima
54.56%
18.21 B
$ 43.15
Argentina
Energy
68
TEO
Telecom Argentina S.A.
54.53%
5.17 B
$ 12.01
Argentina
Communication Services
69
LOMA
Loma Negra Compañía Industr...
53.86%
1.38 B
$ 11.47
Argentina
Basic Materials
70
TGS
Transportadora de Gas del S...
53.05%
4.80 B
$ 31
Argentina
Energy
71
OBIO
Orchestra BioMed Holdings, ...
52.94%
246.37 M
$ 4.21
United States
Healthcare
72
SHMD
SCHMID Group N.V.
51.72%
360.86 M
$ 6.49
Germany
Industrials
73
KDK
Kodiak AI, Inc.
51.51%
1.69 B
$ 9.3
United States
Technology
74
ORKA
Oruka Therapeutics, Inc.
51.29%
3.50 B
$ 69.68
United States
Healthcare
75
SGHT
Sight Sciences, Inc.
51.04%
230.61 M
$ 4.27
United States
Healthcare
76
IMVT
Immunovant, Inc.
51.04%
6.00 B
$ 29.49
United States
Healthcare
77
LXEO
Lexeo Therapeutics, Inc.
50.75%
468.97 M
$ 6.33
United States
Healthcare
78
DTIL
Precision BioSciences, Inc.
50%
204.10 M
$ 7.91
United States
Healthcare
79
GSRT
GSR III Acquisition Corp.
49.95%
303.10 M
$ 10.39
United States
Financial Services
80
CCCX
Churchill Capital Corp X
49.42%
711.00 M
$ 13.66
United States
Financial Services
81
DVLT
Datavault AI Inc.
49.26%
471.60 M
$ 0.7677
United States
Technology
82
SYRE
Spyre Therapeutics, Inc.
48.6%
6.30 B
$ 73
United States
Healthcare
83
GH
Guardant Health, Inc.
48.48%
11.75 B
$ 89.56
United States
Healthcare
84
RGTI
Rigetti Computing, Inc.
48.31%
6.10 B
$ 18.38
United States
Technology
85
GRAL
GRAIL, Inc.
48.13%
2.16 B
$ 52.6
United States
Healthcare
86
CIFR
Cipher Digital Inc.
48.02%
7.89 B
$ 19.44
United States
Technology
87
PAM
Pampa Energía S.A.
47.3%
4.53 B
$ 82.66
Argentina
Industrials
88
QSI
Quantum-Si incorporated
47.26%
229.35 M
$ 1.06
United States
Healthcare
89
AREC
American Resources Corporation
46.95%
256.62 M
$ 2.4
United States
Basic Materials
90
BE
Bloom Energy Corporation
46.54%
65.30 B
$ 229.75
United States
Industrials
91
RCUS
Arcus Biosciences, Inc.
46.29%
3.34 B
$ 26.62
United States
Healthcare
92
DBVT
DBV Technologies S.A.
45.38%
1.16 B
$ 19.64
France
Healthcare
93
QBTS
D-Wave Quantum Inc.
44.6%
7.86 B
$ 21.24
United States
Technology
94
CGEM
Cullinan Therapeutics, Inc.
44.33%
837.68 M
$ 13.84
United States
Healthcare
95
IVVD
Invivyd, Inc.
44.26%
452.49 M
$ 1.6
United States
Healthcare
96
BLTE
Belite Bio, Inc
44.09%
6.69 B
$ 167.42
United States
Healthcare
97
LBRT
Liberty Energy Inc.
44.07%
4.77 B
$ 29.42
United States
Energy
98
ASX
ASE Technology Holding Co.,...
43.85%
65.60 B
$ 29.95
Taiwan
Technology
99
VIST
Vista Energy, S.A.B. de C.V.
43.73%
7.29 B
$ 68.7
Mexico
Energy
100
APGE
Apogee Therapeutics, Inc.
43.7%
6.76 B
$ 90.68
United States
Healthcare
For the most accurate results, consider cross-referencing our data with other sources.

Frequently Asked Questions

Q What is the best stock of October 2025?
A

SPRB (Spruce Biosciences, Inc.) was the best performing stock in October 2025 with a gain of 1,137%. Top performers this month include SPRB, RANI, PRAX.

Q What stocks gained the most in October 2025?
A

The biggest gainers in October 2025 were: SPRB (+1,137%), RANI (+332%), PRAX (+275%), NUAI (+201%), SUPV (+165%). These monthly rankings show which stocks had the strongest short-term momentum.

Q Which sectors performed best in October 2025?
A

The top performing sectors in October 2025 included Healthcare, Technology, Financial Services, based on the stocks with highest monthly gains. SPRB led the Healthcare sector.

Q How is monthly stock performance calculated?
A

Monthly stock performance is calculated by comparing the closing price on the last trading day of the month to the opening price on the first trading day. Split-adjusted prices ensure accuracy.

Q Where can I find today's top stock gainers and most active stocks?
A

This page ranks stocks by their full-month performance in October 2025. For today's top stock gainers, real-time stock movers, and the most active stocks right now, visit our Momentum Scanner which tracks live intraday market activity across NYSE and NASDAQ.

Understanding Monthly Stock Performance

Monthly performance rankings reveal short-term momentum patterns and help identify stocks experiencing rapid price movements:

  • Momentum Trading: Stocks showing strong monthly performance often continue their trend into subsequent months, making this data valuable for momentum-based strategies.
  • Sector Rotation: Monthly rankings can reveal which sectors are gaining favor with investors, signaling potential rotation opportunities.
  • Event-Driven Moves: Earnings releases, product launches, and regulatory approvals often create significant monthly price movements.

Using Monthly Data Effectively

  • Combine Timeframes: Compare monthly gainers with 52-week and YTD performance to identify stocks with both short and long-term momentum.
  • Research the Catalyst: Investigate why top monthly performers moved significantly - understanding the cause helps assess sustainability.
  • Watch for Reversals: Extreme monthly gains sometimes precede corrections, so consider risk management when chasing recent performers.

Evaluate Your Positions

Spotted an opportunity among this month's top movers? Use our Stock Return Calculator to backtest historical performance, or the Position Size Calculator to determine the right allocation for your risk tolerance.