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MARKET LEADERS
52-WEEK LEADER
WOLF +4720%
Wolfspeed, Inc.
2025 YTD LEADER
RGC +9999%
Regencell Bioscience H..
OCT 2025 LEADER
SPRB +1137%
Spruce Biosciences, Inc.
📈 52-Week Top 5 Full List →
1 WOLF +4720.0% 2 BW +2829.2% 3 BE +1452.8% 4 PL +1105.2% 5 TE +669.5%
📅 2025 YTD Top 5 Full List →
1 RGC +9999.0% 2 AXTI +6330.6% 3 ABVX +1573.4% 4 TOI +1464.4% 5 RLMD +1464.1%
🗓 October 2025 Top 5 Full List →
1 SPRB +1137.1% 2 RANI +332.2% 3 PRAX +274.9% 4 NUAI +201.3% 5 SUPV +164.8%
Quick Access: 52-Week 2025 YTD Oct 2025 Market Cap Dividends
#1 SPRB leads with +1,137% October 2025

SPRB (Spruce Biosciences, Inc.) is the best performing stock in October 2025. Following are RANI (+332%) and PRAX (+275%). Top performing sectors: Utilities (+108% avg, 1 in top 10), Financial Services (+103% avg, 1 in top 10), Healthcare (+102% avg, 5 in top 10).

Top Stock Gainers October 2025 - Monthly Performance Ranked

Track the top performing stocks of October 2025 ranked by monthly price gain. See which stock gainers delivered the highest gains this month, with market caps over $100 million on Nasdaq and NYSE.
2025
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec

This ranking shows the top performing stocks and biggest stock gainers during October 2025, calculated from the first to the last trading day of the month. It shows which stocks are going up this month, with split-adjusted data used for consistent performance calculations.

Monthly performance rankings can reveal price strength, sustained momentum, sector rotation, and event-driven moves that are not visible in one-day movers lists. The table is informational only and does not recommend any stock to buy, sell, or hold.

October 2025 Stock Market Momentum

This page answers a current-month trend question with data: which NYSE and NASDAQ stocks have shown the strongest price gains so far in October 2025. The ranking is based on observed market performance, not analyst ratings, price targets, or investment recommendations.

Use the list to research momentum, market breadth, sector strength, and catalysts behind large moves. Before acting on any stock, review the company's news, SEC filings, liquidity, volatility, and your own risk constraints.

Looking for a specific Symbol?

Data as of May 24, 2026 at 3:12 AM EDT

Rank
Symbol
Company Name
Oct Gain
Market Cap
Price
Country
Sector
1
SPRB
Spruce Biosciences, Inc.
1137.08%
140.57 M
$ 51.075
United States
Healthcare
2
RANI
Rani Therapeutics Holdings,...
332.22%
133.76 M
$ 1.07
United States
Healthcare
3
PRAX
Praxis Precision Medicines,...
274.88%
9.58 B
$ 343.56
United States
Healthcare
4
NUAI
New Era Energy & Digital, Inc.
201.33%
448.72 M
$ 4.43
United States
Technology
5
SUPV
Grupo Supervielle S.A.
164.82%
749.45 M
$ 7.93
Argentina
Financial Services
6
DGXX
Digi Power X Inc.
153.36%
717.97 M
$ 7.94
United States
Utilities
7
WKEY
WISeKey International Holdi...
153.35%
120.38 M
$ 10.58
Switzerland
Technology
8
INBX
Inhibrx Biosciences, Inc.
140.32%
1.49 B
$ 101.32
United States
Healthcare
9
VTYX
Ventyx Biosciences Inc
136.94%
1.00 B
$ 14
United States
Healthcare
10
NVA
Nova Minerals Limited
131.35%
235.66 M
$ 6.2
Australia
Basic Materials
11
REPL
Replimune Group, Inc.
131.12%
405.43 M
$ 4.91
United States
Healthcare
12
CURR
CURRENC Group Inc.
126.35%
344.71 M
$ 3.07
Singapore
Technology
13
GSIT
GSI Technology, Inc.
125.56%
349.56 M
$ 9.66
United States
Technology
14
BMA
Banco Macro S.A.
124.02%
4.86 B
$ 75.95
Argentina
Financial Services
15
GGAL
Grupo Financiero Galicia S.A.
122.04%
7.38 B
$ 43.55
Argentina
Financial Services
16
EDN
Empresa Distribuidora y Com...
121.92%
1.15 B
$ 24.1
Argentina
Utilities
17
PHOE
Phoenix Asia Holdings Limited
109.56%
367.42 M
$ 17.01
Hong Kong
Industrials
18
GLTO
Galecto Inc
107.95%
1.73 B
$ 28.69
Denmark
Healthcare
19
BBAR
Banco BBVA Argentina S.A.
105.58%
3.12 B
$ 15.28
Argentina
Financial Services
20
CEPU
Central Puerto S.A.
100.52%
2.09 B
$ 13.91
Argentina
Utilities
21
NERV
Minerva Neurosciences, Inc.
100%
245.06 M
$ 5.26
United States
Healthcare
22
RDZN
Roadzen, Inc.
96.82%
160.36 M
$ 1.9
United States
Technology
23
TMQ
Trilogy Metals Inc.
95.18%
702.26 M
$ 4.07
Canada
Basic Materials
24
NEGG
Newegg Commerce, Inc.
95.14%
425.12 M
$ 20.27
United States
Consumer Cyclical
25
PUMP
ProPetro Holding Corp.
91.16%
2.08 B
$ 16.95
United States
Energy
26
NGNE
Neurogene Inc.
90.6%
437.87 M
$ 27.71
United States
Healthcare
27
LAES
SEALSQ Corp
85.96%
752.98 M
$ 3.38
Switzerland
Technology
28
NVTS
Navitas Semiconductor Corpo...
84.38%
6.84 B
$ 29.25
United States
Technology
29
OPTX
Syntec Optics Holdings, Inc.
84.08%
430.19 M
$ 10.68
United States
Technology
30
VICR
Vicor Corporation
84%
12.22 B
$ 267.99
United States
Technology
31
GNLX
Genelux Corporation
83.64%
130.93 M
$ 2.92
United States
Healthcare
32
IMMX
Immix Biopharma, Inc.
82.69%
477.73 M
$ 8.78
United States
Healthcare
33
IMDX
Insight Molecular Diagnosti...
82.67%
196.65 M
$ 6.09
United States
Healthcare
34
CRML
Critical Metals Corp.
82.51%
1.61 B
$ 10.98
United States
Basic Materials
35
DYN
Dyne Therapeutics, Inc.
80.64%
2.87 B
$ 17.37
United States
Healthcare
36
OMER
Omeros Corporation
77.05%
829.42 M
$ 11.46
United States
Healthcare
37
GLUE
Monte Rosa Therapeutics, Inc.
71.33%
1.59 B
$ 18.81
United States
Healthcare
38
CELC
Celcuity Inc.
70.63%
6.74 B
$ 138.23
United States
Healthcare
39
NAK
Northern Dynasty Minerals Ltd.
70.34%
1.16 B
$ 2.07
Canada
Basic Materials
40
NMRA
Neumora Therapeutics, Inc.
69.66%
342.78 M
$ 1.85
United States
Healthcare
41
PACB
Pacific Biosciences of Cali...
69.57%
378.93 M
$ 1.22
United States
Healthcare
42
LUMN
Lumen Technologies, Inc.
69.36%
9.70 B
$ 9.41
United States
Communication Services
43
SLDP
Solid Power, Inc.
69.27%
688.45 M
$ 3.06
United States
Consumer Cyclical
44
ATXS
Astria Therapeutics, Inc.
67.51%
718.13 M
$ 12.58
United States
Healthcare
45
HBNB
Hotel101 Global Holdings Corp.
65.96%
1.42 B
$ 6.07
Singapore
Real Estate
46
ARMP
Armata Pharmaceuticals, Inc.
65.93%
306.90 M
$ 8.36
United States
Healthcare
47
HKD
AMTD Digital Inc.
65.73%
524.85 M
$ 1.67
France
Technology
48
VELO
Velo3D, Inc.
65.18%
687.21 M
$ 23.06
United States
Technology
49
ACHV
Achieve Life Sciences, Inc.
65.16%
481.47 M
$ 4.69
United States
Healthcare
50
SNDK
Sandisk Corporation
64.57%
218.98 B
$ 1478.69
United States
Technology
51
SABS
SAB Biotherapeutics, Inc.
64.14%
298.21 M
$ 3.9
United States
Healthcare
52
MAMK
MaxsMaking Inc.
63.85%
218.78 M
$ 13.16
China
Industrials
53
EGAN
eGain Corporation
63.12%
192.15 M
$ 7
United States
Technology
54
PYXS
Pyxis Oncology, Inc.
62.56%
124.18 M
$ 1.96
United States
Healthcare
55
RNA
Atrium Therapeutics, Inc.
62.44%
223.91 M
$ 13.09
United States
Healthcare
56
ELDN
Eledon Pharmaceuticals, Inc.
62.41%
300.26 M
$ 3.89
United States
Healthcare
57
AXTI
AXT, Inc.
61.91%
9.21 B
$ 140.83
United States
Technology
58
BALY
Bally's Corporation
59.74%
646.12 M
$ 13.2
United States
Consumer Cyclical
59
NAUT
Nautilus Biotechnology, Inc.
59.24%
322.78 M
$ 2.54
United States
Healthcare
60
PALI
Palisade Bio, Inc.
58.02%
338.87 M
$ 1.95
United States
Healthcare
61
CABA
Cabaletta Bio, Inc.
56.28%
595.15 M
$ 3.65
United States
Healthcare
62
REKR
Rekor Systems, Inc.
56.17%
105.70 M
$ 0.7681
United States
Technology
63
AMD
Advanced Micro Devices, Inc.
56.16%
762.32 B
$ 467.51
United States
Technology
64
FLNC
Fluence Energy, Inc.
56.13%
3.96 B
$ 21.49
United States
Utilities
65
TSHA
Taysha Gene Therapies, Inc.
55.97%
1.58 B
$ 5.49
United States
Healthcare
66
SKYX
SKYX Platforms Corp.
55.75%
151.97 M
$ 1.13
United States
Industrials
67
TE
T1 Energy Inc.
55.65%
2.26 B
$ 8.08
United States
Industrials
68
BNR
Burning Rock Biotech Limited
55.25%
153.03 M
$ 14.51
China
Healthcare
69
YPF
YPF Sociedad Anónima
54.56%
20.25 B
$ 47.99
Argentina
Energy
70
TEO
Telecom Argentina S.A.
54.53%
5.11 B
$ 11.86
Argentina
Communication Services
71
LOMA
Loma Negra Compañía Industr...
53.86%
1.28 B
$ 10.95
Argentina
Basic Materials
72
TGS
Transportadora de Gas del S...
53.05%
4.38 B
$ 29.07
Argentina
Energy
73
OBIO
Orchestra BioMed Holdings, ...
52.94%
243.12 M
$ 4.06
United States
Healthcare
74
SHMD
SCHMID Group N.V.
51.72%
432.93 M
$ 7.49
Germany
Industrials
75
KDK
Kodiak AI, Inc.
51.51%
1.38 B
$ 7.78
United States
Technology
76
ORKA
Oruka Therapeutics, Inc.
51.29%
3.66 B
$ 60.61
United States
Healthcare
77
SGHT
Sight Sciences, Inc.
51.04%
273.68 M
$ 5.03
United States
Healthcare
78
IMVT
Immunovant, Inc.
51.04%
7.01 B
$ 34.15
United States
Healthcare
79
LXEO
Lexeo Therapeutics, Inc.
50.75%
401.25 M
$ 5.11
United States
Healthcare
80
DTIL
Precision BioSciences, Inc.
50%
186.55 M
$ 7.23
United States
Healthcare
81
GSRT
GSR III Acquisition Corp.
49.95%
303.10 M
$ 10.39
United States
Financial Services
82
CCCX
Churchill Capital Corp X
49.42%
711.00 M
$ 13.66
United States
Financial Services
83
DVLT
Datavault AI Inc.
49.26%
397.15 M
$ 0.4642
United States
Technology
84
SYRE
Spyre Therapeutics, Inc.
48.6%
6.43 B
$ 74.05
United States
Healthcare
85
GH
Guardant Health, Inc.
48.48%
15.77 B
$ 118.95
United States
Healthcare
86
RGTI
Rigetti Computing, Inc.
48.31%
8.78 B
$ 26.42
United States
Technology
87
GRAL
GRAIL, Inc.
48.13%
2.88 B
$ 67.19
United States
Healthcare
88
CIFR
Cipher Digital Inc.
48.02%
8.99 B
$ 21.97
United States
Technology
89
PAM
Pampa Energía S.A.
47.3%
4.34 B
$ 80.68
Argentina
Industrials
90
QSI
Quantum-Si incorporated
47.26%
230.83 M
$ 1.06
United States
Healthcare
91
AREC
American Resources Corporation
46.95%
231.06 M
$ 2.16
United States
Basic Materials
92
BE
Bloom Energy Corporation
46.54%
86.04 B
$ 302.49
United States
Industrials
93
RCUS
Arcus Biosciences, Inc.
46.29%
2.95 B
$ 23.43
United States
Healthcare
94
DBVT
DBV Technologies S.A.
45.38%
1.08 B
$ 18.18
France
Healthcare
95
QBTS
D-Wave Quantum Inc.
44.6%
10.89 B
$ 29.4
United States
Technology
96
CGEM
Cullinan Therapeutics, Inc.
44.33%
850.58 M
$ 13.84
United States
Healthcare
97
IVVD
Invivyd, Inc.
44.26%
324.07 M
$ 1.1
United States
Healthcare
98
BLTE
Belite Bio, Inc
44.09%
5.50 B
$ 137.3
United States
Healthcare
99
LBRT
Liberty Energy Inc.
44.07%
5.20 B
$ 31.84
United States
Energy
100
ASX
ASE Technology Holding Co.,...
43.85%
76.37 B
$ 34.81
Taiwan
Technology
For the most accurate results, consider cross-referencing our data with other sources.

Frequently Asked Questions

Q Which stock has gained the most in October 2025?
A

SPRB (Spruce Biosciences, Inc.) has the highest monthly gain in this ranking for October 2025, with a gain of 1,137%. Top performers this month include SPRB, RANI, PRAX.

Q What stocks gained the most in October 2025?
A

The biggest gainers in October 2025 were: SPRB (+1,137%), RANI (+332%), PRAX (+275%), NUAI (+201%), SUPV (+165%). These monthly rankings show which stocks had the strongest short-term momentum.

Q Does this page recommend the best stocks to buy now?
A

No. This page is an informational ranking of stocks that have already gone up during October 2025. It does not make buy, sell, or hold recommendations and should be used as a research starting point, not financial advice.

Q How can this ranking help explain current stock market trends?
A

The ranking shows where price strength is concentrated during October 2025. Comparing the top gainers by sector, market cap, and recent catalysts can help identify momentum themes and market rotation without implying that any listed stock is a recommendation.

Q Which sectors performed best in October 2025?
A

The top performing sectors in October 2025 included Healthcare, Technology, Financial Services, based on the stocks with highest monthly gains. SPRB led the Healthcare sector.

Q How is monthly stock performance calculated?
A

Monthly stock performance is calculated by comparing the closing price on the last trading day of the month to the opening price on the first trading day. Split-adjusted prices ensure accuracy.

Q Where can I find today's top stock gainers and most active stocks?
A

This page ranks stocks by their full-month performance in October 2025. For today's top stock gainers, real-time stock movers, and the most active stocks right now, visit our Momentum Scanner which tracks live intraday market activity across NYSE and NASDAQ.

Understanding Monthly Stock Performance

Monthly performance rankings reveal short-term momentum patterns and help identify stocks experiencing rapid price movements:

  • Momentum Research: Stocks showing strong monthly performance can help identify where market attention and price strength are concentrated.
  • Sector Rotation: Monthly rankings can reveal which sectors are gaining favor with investors and where market leadership is shifting.
  • Event-Driven Moves: Earnings releases, product launches, and regulatory approvals often create significant monthly price movements.

Using Monthly Data Effectively

  • Combine Timeframes: Compare monthly gainers with 52-week and YTD performance to identify stocks with both short and long-term momentum.
  • Research the Catalyst: Investigate why top monthly performers moved significantly. The reason for the move matters as much as the percentage gain.
  • Watch for Reversals: Extreme monthly gains sometimes precede corrections, so treat the ranking as a research starting point rather than a buy list.

Evaluate Your Positions

Researching one of this month's top movers? Use our Stock Return Calculator to review historical performance, or the Position Size Calculator to model position sizing and risk before making your own decision.