GSK PLC (GLAXF) filings document foreign-issuer disclosures for a global biopharma company registered in England and Wales. The record centers on Form 6-K current reports furnished under the Exchange Act, including announcements on product collaborations, capital-return programs, annual general meeting voting results, remuneration matters, board elections, and transaction notifications involving American Depositary Shares.
The filings also describe GSK's securities framework, including ordinary shares and ADS instruments, share repurchases and treasury-share treatment, PDMR transaction reporting, and governance resolutions connected with annual reporting and shareholder approvals. Product-related reports identify bepirovirsen in chronic hepatitis B and outline regulatory, quality, pharmacovigilance, commercial access, and global medical-strategy responsibilities associated with collaboration arrangements.
GSK plc reported its total voting rights as of 31 March 2026. The company had 4,316,179,781 issued ordinary shares of 31 ¼ pence each, with 256,112,615 shares held in treasury. This leaves 4,060,067,166 voting rights, which shareholders can use as the denominator for disclosure threshold calculations under UK transparency rules.
GSK plc reports that, acting through BNP Paribas, it repurchased 340,000 ordinary shares of 31¼ pence each on 31 March 2026 as part of its existing share buyback programme. Prices ranged from 2,064.00p to 2,086.00p per share, with a volume-weighted average price of 2,075.26p.
The repurchased shares will be held as treasury shares. Since 17 February 2026, GSK has bought back 16,221,521 ordinary shares. After this transaction, GSK holds 256,112,615 shares in treasury and has 4,060,067,166 ordinary shares in issue, giving a total of 4,060,067,166 voting rights. Treasury shares represent 6.31% of the company’s voting rights under DTR 5.5.1R.
GSK plc has completed a reshaping of ownership in HIV specialist ViiV Healthcare as Pfizer exits its investment and Shionogi increases its stake. Shionogi’s economic interest in ViiV Healthcare rises to 21.7%, while GSK maintains a 78.3% majority interest.
ViiV Healthcare issued new shares to Shionogi for $2.125 billion, cancelled Pfizer’s holding, and paid $1.875 billion to Pfizer and a $0.250 billion special dividend to GSK. GSK’s previously recorded Pfizer put option liability was extinguished through retained earnings at completion, with the final fair value remeasurement recognised as an adjusting item in other operating income.
GSK plc repurchased 340,000 ordinary shares on 30 March 2026 through BNP Paribas under its existing share buyback programme. The shares, each with a nominal value of 31¼ pence, were bought at prices between 2,045.00p and 2,070.00p, with a volume-weighted average price of 2,060.19p.
The purchased shares will be held as Treasury shares. Since 17 February 2026, GSK has bought 15,881,521 ordinary shares. After this transaction, it holds 255,772,615 shares in treasury and has 4,060,407,166 ordinary shares in issue, which is also the total number of voting rights.
GSK confirms that, under DTR 5.5.1R, 6.30 per cent of its voting rights are attributable to ordinary shares held in treasury. The filing also provides a detailed schedule of buyback trades across the London Stock Exchange and CBOE Europe venues.
GSK plc reports that China’s National Medical Products Administration has accepted for review a new drug application for bepirovirsen to treat adults with chronic hepatitis B. The investigational antisense oligonucleotide showed statistically significant and clinically meaningful functional cure rates in pivotal Phase III B-Well 1 and B-Well 2 trials.
Functional cure means hepatitis B virus DNA and hepatitis B surface antigen are undetectable in blood for at least 24 weeks after stopping all treatment, indicating immune control without medication. Current standard nucleos(t)ide analogue therapies typically achieve functional cure in only about 1% of patients.
Bepirovirsen, licensed from Ionis Pharmaceuticals, has Breakthrough Therapy designation in China, Fast Track designation in the US and SENKU designation in Japan, but is not yet approved anywhere. Chronic hepatitis B affects more than 250 million people worldwide and an estimated 75 million people in China, causing around 450,000 deaths a year in China.
GSK plc reports that China’s National Medical Products Administration has approved Exdensur (depemokimab) as an add-on maintenance treatment for severe asthma with an eosinophilic phenotype in patients aged 12 and older. Exdensur is described as the first and only ultra-long-acting biologic in China for this condition and is dosed twice yearly.
The approval is based on the phase III SWIFT-1 and SWIFT-2 trials, where depemokimab plus standard of care significantly reduced annualised asthma exacerbations compared with placebo plus standard of care. In SWIFT-1 and SWIFT-2, exacerbation rates fell by 58% and 48% over 52 weeks, and pooled data showed a 72% reduction in clinically significant exacerbations requiring hospital or emergency visits.
Across the SWIFT trials, depemokimab showed a safety and tolerability profile similar to placebo. GSK notes that more than 2 million people in China are affected by severe asthma and highlights that Exdensur is already approved for severe asthma, and in some regions for chronic rhinosinusitis with nasal polyps, in the US, Japan, the EU and the UK.
GSK plc reports that, through BNP Paribas, it repurchased 340,000 ordinary shares on 27 March 2026 under its existing share buyback programme at a volume‑weighted average price of 2,043.51p, within a 2,024.00p–2,060.00p range.
The shares will be held as treasury shares. Since 17 February 2026, GSK has bought back 15,541,521 shares. After this transaction, GSK holds 255,432,615 shares in treasury and has 4,060,747,166 shares in issue, giving total voting rights of 4,060,747,166 and a 6.29% treasury holding.
GSK plc reports that it has repurchased 345,000 ordinary shares of 31¼ pence each on 26 March 2026 through BNP Paribas under its existing share buyback programme. The shares were bought at prices between 2,037.00p and 2,072.00p, with a volume‑weighted average price of 2,053.34p per share.
The repurchased shares will be held as treasury shares. Since 17 February 2026, GSK has bought a total of 15,201,521 ordinary shares. After this transaction, GSK holds 255,092,615 shares in treasury and has 4,061,083,663 ordinary shares in issue, which is also the total number of voting rights. Treasury shares represent 6.28% of voting rights.
GSK plc reports that the European Medicines Agency has accepted for review a marketing authorisation application for bepirovirsen, an investigational antisense oligonucleotide for adults with chronic hepatitis B. The submission is backed by Phase III B‑Well 1 and B‑Well 2 trials, which met their primary endpoint and showed statistically significant, clinically meaningful functional cure rates versus standard of care.
Chronic hepatitis B affects an estimated 3.2 million people in Europe and more than 250 million worldwide, with current nucleos(t)ide analogue therapies often requiring lifelong treatment and achieving functional cure in only about 1% of patients. Bepirovirsen is designed to target hepatitis B viral RNA, reduce hepatitis B surface antigen, and stimulate the immune system, with trials indicating an acceptable safety and tolerability profile. The data will be presented at a scientific congress and submitted for peer‑reviewed publication in 2026, while bepirovirsen remains unapproved globally.
GSK plc reports that on 25 March 2026 it repurchased 345,000 ordinary shares of 31¼ pence each through BNP Paribas under its existing share buyback programme. Prices ranged from 1,988.50p to 2,047.00p per share, with a volume‑weighted average price of 2,033.20p.
The repurchased shares will be held as treasury shares. Since 17 February 2026, GSK has bought a total of 14,856,521 ordinary shares. After this transaction, it holds 254,747,615 shares in treasury and has 4,061,428,663 ordinary shares in issue, which is also the total number of voting rights.
The company states that, in line with DTR 5.5.1R, treasury shares represent 6.27% of the voting rights. Detailed schedules list the number of shares and prices per trade across London Stock Exchange and Cboe Europe venues.