Ionis Pharmaceuticals SEC Filings

Insider notice to sell common stock: A Form 144 filing shows proposed sale of 437 shares of common stock on 10/06/2025 via Stifel Nicolaus & Company on Nasdaq with an aggregate market value of $30,268.00. The shares were acquired under an Employee Stock Purchase Plan on 09/03/2024 and paid in cash. The filer represents no undisclosed material adverse information and the filing includes prior sales by the same person totaling 208,648 shares across dates in 2025 with gross proceeds shown (largest single prior sale: $12,228,840.00 on 09/03/2025). The notice states standard Rule 144 and Rule 10b5-1 remarks and signature attestation.

Form 144 notice shows a proposed sale of 1,625 common shares by an insider who acquired them as restricted stock units on 04/15/2025. The shares are to be sold through Stifel Nicolaus & Company on 10/06/2025 with an aggregate market value of $112,725.00 based on the filing. The issuer reports 159,391,229 shares outstanding.

The filer disclosed prior insider sales totaling 60,000 shares during the past three months (sales on 09/03/2025, 09/05/2025, 09/09/2025, and 10/02/2025) generating $3,724,770.00 in gross proceeds. The current notice states the securities were paid for in cash at acquisition and were granted by the issuer as RSUs.

Ionis Pharmaceuticals, Inc. filed a Form 144 notice reporting a proposed sale of 6,849 shares of common stock, with an aggregate market value of $472,718, to be executed approximately on 10/06/2025 through Stifel Nicolaus & Company on Nasdaq. The shares were acquired as Restricted Stock Units from the issuer on 01/15/2025 and paid for in cash on the same date. The filer reports total shares outstanding of 159,391,229. The notice also lists three prior sales by the same person, Eric Swayze, totaling 38,244 shares sold on 09/02/2025, 10/01/2025, and 10/02/2025, generating combined gross proceeds of $2,346,609. The signer affirms no undisclosed material adverse information and references Rule 10b5-1 conditions.

IONIS PHARMACEUTICALS, INC. (IONS) Rule 144 notice reports a proposed sale of 22,400 shares of common stock through Goldman Sachs & Co. LLC on 10/01/2025, with an aggregate market value of $1,473,920. The filing lists total shares outstanding of 159,391,229. The securities were acquired on multiple dates by the reporting party (option exercise and restricted stock units), including notable lots: 3,560 shares (09/16/2020), 6,394 shares (07/17/2018), 5,300 shares (02/14/2014) and 4,677 shares (07/15/2024). The filing also discloses related sales by the Joseph H. Wender Trust totaling 33,600 shares in Sep–Oct 2025 for gross proceeds of approximately $1.98 million. Other issuer identification fields are blank in the form content provided.

Patrick R. O'Neil, Executive Vice President, Chief Legal Officer & General Counsel of Ionis Pharmaceuticals (IONS), reported option exercises and subsequent sales on September 29-30, 2025. The Form 4 shows Mr. O'Neil acquired 10,473 shares on 09/29/2025 and 14,827 shares on 09/30/2025 via exercise of non-qualified stock options with an exercise price of $56.78 per share. On the same dates he sold the exercised shares: 10,473 shares on 09/29/2025 at a weighted average price of $64.5417, and 14,827 shares on 09/30/2025 at a weighted average price of $64.6777. The sales were executed pursuant to a Rule 10b5-1 trading plan adopted May 2, 2025. Following these transactions, Mr. O'Neil beneficially owned 57,130 shares.

Richard S. Geary, EVP & Chief Development Officer of Ionis Pharmaceuticals (IONS), reported option exercise and share sales on 09/30/2025. He exercised a non-qualified stock option with a $53.77 exercise price to acquire 57,900 shares, increasing his direct beneficial ownership to 137,557 shares. On the same date he sold 57,900 shares under a Rule 10b5-1 trading plan adopted May 6, 2025, for a weighted-average price of $65.2447 per share, with individual sale prices in the $65.00 to $65.52 range. The filing was submitted by an attorney-in-fact.

IONIS PHARMACEUTICALS, INC. (IONS) submitted a Form 144 reporting a proposed sale of 27,114 shares of common stock through Stifel Nicolaus & Company on Nasdaq, with an aggregate market value of $1,789,524 and total shares outstanding reported as 159,391,229. The filer reports acquiring 17,114 of these shares on 01/15/2021 by option exercise, with payment listed as cash and an approximate sale date of 10/01/2025.

The filing also discloses a prior sale by the same person on 09/02/2025 of 11,130 shares for $552,865. By simple proportion, the proposed sale represents approximately 0.017% of outstanding shares, indicating the transaction is small relative to the company's share count. The notice contains the standard insider representation about absence of undisclosed material information.

Form 144 filing by Ionis Pharmaceuticals (IONS) reports a proposed sale of 49,800 shares of common stock through Stifel Nicolaus & Company, with an aggregate market value of $3,249,734.00. The shares are listed on Nasdaq and the filing lists 159,391,229 shares outstanding for the issuer. The securities were acquired on 01/02/2019 by option exercise from the issuer and the intended sale is scheduled for 09/30/2025 with payment in cash. The filer reports no sales in the past three months and includes the standard representation that the seller does not possess undisclosed material adverse information.

Ionis Pharmaceuticals announced positive topline results from the pivotal study of zilganersen 50 mg in children and adults with Alexander disease (AxD). The drug met the study's primary endpoint: stabilization in gait speed on the 10-Meter Walk Test at week 61, showing a mean difference of 33.3% (p=0.0412) versus control. The company reports consistent benefit across key secondary endpoints related to patient- and clinician-reported measures and says safety and tolerability were favorable, with most adverse events mild or moderate and serious adverse events numerically lower in the zilganersen arm.

Ionis plans to submit a new drug application to the U.S. FDA in Q1 2026 and is evaluating an Expanded Access Program in the U.S. Detailed data will be presented at an upcoming medical conference.