Vertex (VRTX) CMO Carmen Bozic executes Rule 10b5-1 sale of 2,329 shares

Rhea-AI Filing Summary

Vertex Pharmaceuticals EVP and CMO Carmen Bozic sold common stock in a planned transaction. On February 27, 2026, she completed an open-market sale of 2,329 shares of Vertex common stock at an average price of $480.31 per share. After the sale, she directly owned 37,734 shares. The trade was made under a pre-established Rule 10b5-1 trading plan entered on November 20, 2025.

Insider Trade Summary

Net Seller: 2,329 shares ($1,118,642)

Net Sell 1 txn

Insider Bozic Carmen

Role EVP and CMO

Sold 2,329 shs ($1.12M)

Type	Security	Shares	Price	Value
Sale	Common Stock	2,329	$480.31	$1.12M

Holdings After Transaction: Common Stock — 37,734 shares (Direct)

Footnotes (1)

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Form 4 Insider Transactions: What Each Field Means →

SEC Form 4

FORM 4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940

OMB APPROVAL

OMB Number:			3235-0287
Estimated average burden
hours per response:			0.5

Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).

X

Check this box to indicate that a transaction was made pursuant to a contract, instruction or written plan for the purchase or sale of equity securities of the issuer that is intended to satisfy the affirmative defense conditions of Rule 10b5-1(c). See Instruction 10.

1. Name and Address of Reporting Person^*

Bozic Carmen

(Last) (First) (Middle)

C/O VERTEX PHARMACEUTICALS INCORPORATED

50 NORTHERN AVENUE

(Street)

BOSTON MA 02210

(City) (State) (Zip)

2. Issuer Name and Ticker or Trading Symbol
VERTEX PHARMACEUTICALS INC / MA [ VRTX ]

5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)

	Director		10% Owner
X	Officer (give title below)		Other (specify below)
	EVP and CMO

3. Date of Earliest Transaction (Month/Day/Year)
02/27/2026

4. If Amendment, Date of Original Filed (Month/Day/Year)

6. Individual or Joint/Group Filing (Check Applicable Line)

X	Form filed by One Reporting Person
	Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1. Title of Security (Instr. 3)	2. Transaction Date (Month/Day/Year)	2A. Deemed Execution Date, if any (Month/Day/Year)	3. Transaction Code (Instr. 8)		4. Securities Acquired (A) or Disposed Of (D) (Instr. 3, 4 and 5)			5. Amount of Securities Beneficially Owned Following Reported Transaction(s) (Instr. 3 and 4)	6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	7. Nature of Indirect Beneficial Ownership (Instr. 4)
			Code	V	Amount	(A) or (D)	Price
Common Stock	02/27/2026		S(1)		2,329	D	$480.31	37,734	D

Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 3)	2. Conversion or Exercise Price of Derivative Security	3. Transaction Date (Month/Day/Year)	3A. Deemed Execution Date, if any (Month/Day/Year)	4. Transaction Code (Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D) (Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date (Month/Day/Year)		7. Title and Amount of Securities Underlying Derivative Security (Instr. 3 and 4)		8. Price of Derivative Security (Instr. 5)	9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)	10. Ownership Form: Direct (D) or Indirect (I) (Instr. 4)	11. Nature of Indirect Beneficial Ownership (Instr. 4)
				Code	V	(A)	(D)	Date Exercisable	Expiration Date	Title	Amount or Number of Shares

Explanation of Responses:

1. Transaction made pursuant to Dr. Bozic's company approved trading plan under Rule 10b5-1, which was entered into on 11/20/2025.

Remarks:

	/s/ Christiana Stevenson, Attorney-in-Fact	03/03/2026
	** Signature of Reporting Person	Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 4 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.

FAQ

What did Vertex (VRTX) EVP and CMO Carmen Bozic report in this Form 4?

Carmen Bozic reported an open-market sale of Vertex common stock. She sold 2,329 shares at an average price of $480.31 per share and continued to hold 37,734 shares directly after the transaction, according to the Form 4 disclosure.

How many Vertex (VRTX) shares did Carmen Bozic sell and at what price?

Carmen Bozic sold 2,329 shares of Vertex common stock. The reported average sale price was $480.31 per share, reflecting a single non-derivative open-market transaction disclosed in the Form 4 insider trading report.

How many Vertex (VRTX) shares does Carmen Bozic hold after this transaction?

After the reported sale, Carmen Bozic directly owns 37,734 shares of Vertex common stock. This post-transaction holding reflects her remaining direct ownership following the disposition of 2,329 shares in the open market.

Was the Vertex (VRTX) insider sale by Carmen Bozic under a Rule 10b5-1 plan?

Yes, the transaction was executed under a company-approved Rule 10b5-1 trading plan. The footnote states the plan was entered into on November 20, 2025, and the February 27, 2026 sale was carried out pursuant to that pre-arranged plan.

What is the nature of ownership for Carmen Bozic’s remaining Vertex (VRTX) shares?

The Form 4 indicates that Carmen Bozic’s remaining 37,734 Vertex shares are held with direct ownership. The ownership code is shown as “D,” meaning she holds these shares in her own name rather than through an indirect entity.

What transaction code is used for Carmen Bozic’s Vertex (VRTX) stock sale?

The filing uses transaction code “S” for the stock sale. This code indicates a sale in the open market or a private transaction, which in this case is described as an open-market sale of Vertex common stock.