What is Orchestra BioMed Holdings Inc's earnings per share (EPS)?

Orchestra BioMed Holdings Inc (OBIO) reported diluted earnings per share of $-1.11 for fiscal year 2025. This represents a 33.1% change compared to the previous fiscal year. EPS represents the portion of a company's net income allocated to each outstanding share of common stock and is widely used to evaluate profitability on a per-share basis.

Orchestra BioMed Holdings Inc Financials

OBIO

Source SEC Filings (10-K/10-Q) Updated Dec 31, 2025 Currency USD FYE December

This page shows Orchestra BioMed Holdings Inc (OBIO) financial statements, including the income statement, balance sheet, cash flow statement, and key financial ratios. View 5 years of annual fundamentals and quarterly data, with year-over-year growth rates and compound annual growth rates (CAGR). All figures are derived from SEC filings (10-K and 10-Q reports).

Financial Health Signals

Financial Profile 49/100

Based on FY2025 annual data. Scores normalized against common benchmarks. How we calculate these scores

Profitability

Orchestra BioMed Holdings Inc has an operating margin of -154.7%, meaning the company retains $-155 of operating profit per $100 of revenue. This below-average margin results in a low score of 0/100, suggesting thin profitability after operating expenses. This is up from -2437.5% the prior year.

Growth

100

Orchestra BioMed Holdings Inc's revenue surged 1169.2% year-over-year to $33.5M, reflecting rapid business expansion. This strong growth earns a score of 100/100.

Leverage

Orchestra BioMed Holdings Inc carries a low D/E ratio of 0.28, meaning only $0.28 of long-term debt for every $1 of shareholders' equity. This conservative leverage earns a score of 96/100, indicating a strong balance sheet with room for future borrowing.

Liquidity

100

With a current ratio of 6.45, Orchestra BioMed Holdings Inc holds $6.45 in current assets for every $1 of short-term obligations. This comfortable liquidity earns a score of 100/100.

Cash Flow

While Orchestra BioMed Holdings Inc generated -$49.0M in operating cash flow, capex of $489K consumed most of it, leaving -$49.5M in free cash flow. This results in a low score of 0/100, reflecting heavy capital investment rather than weak cash generation.

Returns

Orchestra BioMed Holdings Inc generates a -98.4% ROE, indicating limited profit relative to shareholders' investment. This results in a returns score of 0/100. This is up from -185.2% the prior year.

Piotroski F-Score Neutral

6/9

Orchestra BioMed Holdings Inc passes 6 of 9 financial strength tests. 2 of 4 profitability signals pass, 2 of 3 leverage/liquidity signals pass, both operating efficiency signals pass.

Earnings Quality Low Quality

0.93x

For every $1 of reported earnings, Orchestra BioMed Holdings Inc generates $0.93 in operating cash flow (-$49.0M OCF vs -$52.7M net income). This low ratio suggests earnings are primarily driven by accounting accruals rather than cash generation, which may not be sustainable.

Key Financial Metrics

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Earnings & Revenue

Revenue

$33.5M

YoY+1169.2%

Orchestra BioMed Holdings Inc generated $33.5M in revenue in fiscal year 2025. This represents an increase of 1169.2% from the prior year.

EBITDA

-$51.5M

YoY+19.6%

Orchestra BioMed Holdings Inc's EBITDA was -$51.5M in fiscal year 2025, measuring earnings before interest, taxes, depreciation, and amortization. This represents an increase of 19.6% from the prior year.

Net Income

-$52.7M

YoY+13.6%

Orchestra BioMed Holdings Inc reported -$52.7M in net income in fiscal year 2025. This represents an increase of 13.6% from the prior year.

EPS (Diluted)

$-1.11

YoY+33.1%

Orchestra BioMed Holdings Inc earned $-1.11 per diluted share (EPS) in fiscal year 2025. This represents an increase of 33.1% from the prior year.

Cash & Balance Sheet

Free Cash Flow

-$49.5M

YoY+2.7%

Orchestra BioMed Holdings Inc generated -$49.5M in free cash flow in fiscal year 2025, representing cash available after capex. This represents an increase of 2.7% from the prior year.

Cash & Debt

$34.7M

YoY+55.8%

Orchestra BioMed Holdings Inc held $34.7M in cash against $15.0M in long-term debt as of fiscal year 2025.

Dividends Per Share

N/A

Shares Outstanding

57M

YoY+49.3%

Orchestra BioMed Holdings Inc had 57M shares outstanding in fiscal year 2025. This represents an increase of 49.3% from the prior year.

Margins & Returns

Gross Margin

99.4%

YoY+7.2pp

Orchestra BioMed Holdings Inc's gross margin was 99.4% in fiscal year 2025, indicating the percentage of revenue retained after direct costs. This is up 7.2 percentage points from the prior year.

Operating Margin

-154.7%

YoY+2282.8pp

Orchestra BioMed Holdings Inc's operating margin was -154.7% in fiscal year 2025, reflecting core business profitability. This is up 2282.8 percentage points from the prior year.

Net Margin

-157.4%

YoY+2155.9pp

Orchestra BioMed Holdings Inc's net profit margin was -157.4% in fiscal year 2025, showing the share of revenue converted to profit. This is up 2155.9 percentage points from the prior year.

Return on Equity

-98.4%

YoY+86.8pp

Orchestra BioMed Holdings Inc's ROE was -98.4% in fiscal year 2025, measuring profit generated per dollar of shareholder equity. This is up 86.8 percentage points from the prior year.

Capital Allocation

R&D Spending

$58.2M

YoY+35.9%

Orchestra BioMed Holdings Inc invested $58.2M in research and development in fiscal year 2025. This represents an increase of 35.9% from the prior year.

Share Buybacks

N/A

Capital Expenditures

$489K

YoY+69.2%

Orchestra BioMed Holdings Inc invested $489K in capex in fiscal year 2025, funding long-term assets and infrastructure. This represents an increase of 69.2% from the prior year.

OBIO Income Statement

Metric	FY25	FY24	FY23	FY22	FY21
Revenue	$33.5M+1169.2%	$2.6M-4.4%	$2.8M-21.9%	$3.5M	N/A
Cost of Revenue	$190K-6.9%	$204K+9.7%	$186K-11.8%	$211K	N/A
Gross Profit	$33.3M+1267.8%	$2.4M-5.4%	$2.6M-22.5%	$3.3M	N/A
R&D Expenses	$58.2M+35.9%	$42.8M+26.6%	$33.8M+54.1%	$21.9M	N/A
SG&A Expenses	$26.9M+12.5%	$23.9M+18.1%	$20.3M+44.3%	$14.0M+5007.8%	$275K
Operating Income	-$51.8M+19.4%	-$64.3M-24.8%	-$51.5M-57.7%	-$32.7M-8172.7%	-$395K
Interest Expense	N/A	$297K-78.8%	$1.4M+7.7%	$1.3M	N/A
Income Tax	$0	N/A	N/A	N/A	N/A
Net Income	-$52.7M+13.6%	-$61.0M-24.2%	-$49.1M-46.2%	-$33.6M-8773.3%	-$379K
EPS (Diluted)	$-1.11+33.1%	$-1.66-12.2%	$-1.48	$-2.24-11100.0%	$-0.02

Metric	Q4'25	Q3'25	Q2'25	Q1'25	Q4'24	Q3'24	Q2'24	Q1'24
Revenue	$30.9M+3490.8%	$861K+3.0%	$836K-3.7%	$868K+243.1%	$253K-74.4%	$987K+26.9%	$778K+25.5%	$620K
Cost of Revenue	$51K+4.1%	$49K+6.5%	$46K+4.5%	$44K-24.1%	$58K-14.7%	$68K+54.5%	$44K+29.4%	$34K
Gross Profit	$30.9M+3701.2%	$812K+2.8%	$790K-4.1%	$824K+322.6%	$195K-78.8%	$919K+25.2%	$734K+25.3%	$586K
R&D Expenses	$16.8M+19.9%	$14.0M+1.3%	$13.9M+2.8%	$13.5M+22.9%	$11.0M-5.4%	$11.6M+4.2%	$11.1M+22.1%	$9.1M
SG&A Expenses	$7.3M+2.7%	$7.1M+13.3%	$6.3M0.0%	$6.3M+6.1%	$5.9M+4.1%	$5.7M-12.4%	$6.5M+9.7%	$5.9M
Operating Income	$6.8M+133.2%	-$20.3M-5.1%	-$19.3M-2.1%	-$18.9M-13.5%	-$16.7M-2.0%	-$16.3M+3.1%	-$16.9M-16.9%	-$14.4M
Interest Expense	N/A	N/A	N/A	N/A	$297K	$0	$0	$0
Income Tax	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Net Income	$6.2M+130.0%	-$20.8M-7.6%	-$19.4M-3.2%	-$18.8M-16.1%	-$16.2M-4.7%	-$15.4M+3.5%	-$16.0M-18.7%	-$13.5M
EPS (Diluted)	N/A	$-0.40+20.0%	$-0.50-2.0%	$-0.49	N/A	$-0.41+8.9%	$-0.45-18.4%	$-0.38

OBIO Balance Sheet

Metric	FY25	FY24	FY23	FY22	FY21
Total Assets	$114.9M+50.8%	$76.2M-20.0%	$95.2M-0.4%	$95.6M-40.9%	$161.8M
Current Assets	$107.9M+56.0%	$69.2M-22.4%	$89.1M+5.2%	$84.7M+4602.1%	$1.8M
Cash & Equivalents	$34.7M+55.8%	$22.3M-27.2%	$30.6M+54.5%	$19.8M+1027.6%	$1.8M
Inventory	$310K+79.2%	$173K+18.5%	$146K-47.1%	$276K	N/A
Accounts Receivable	$95K+3.3%	$92K-7.1%	$99K+3.1%	$96K	N/A
Goodwill	N/A	N/A	N/A	N/A	N/A
Total Liabilities	$51.5M+19.1%	$43.2M+59.1%	$27.2M-36.9%	$43.0M-76.3%	$181.6M
Current Liabilities	$16.7M+3.3%	$16.2M+44.6%	$11.2M-39.6%	$18.6M+11115.5%	$166K
Long-Term Debt	$15.0M0.0%	$15.0M	N/A	N/A	N/A
Total Equity	$53.6M+62.5%	$33.0M-51.6%	$68.0M+29.5%	$52.5M+365.6%	-$19.8M
Retained Earnings	-$362.6M-17.0%	-$309.9M-24.5%	-$248.9M-24.6%	-$199.7M-4966.3%	-$3.9M

Metric	Q4'25	Q3'25	Q2'25	Q1'25	Q4'24	Q3'24	Q2'24	Q1'24
Total Assets	$114.9M+9.6%	$104.8M+144.7%	$42.8M-27.5%	$59.1M-22.5%	$76.2M+1.1%	$75.3M+4.1%	$72.4M-12.4%	$82.6M
Current Assets	$107.9M+10.4%	$97.8M+172.5%	$35.9M-30.9%	$51.9M-25.0%	$69.2M+0.9%	$68.6M+3.1%	$66.5M-13.0%	$76.4M
Cash & Equivalents	$34.7M-17.4%	$42.0M+124.1%	$18.7M+2.2%	$18.3M-17.6%	$22.3M-13.1%	$25.6M+8.0%	$23.7M+1.7%	$23.3M
Inventory	$310K-15.1%	$365K+97.3%	$185K+37.0%	$135K-22.0%	$173K-26.1%	$234K+234.3%	$70K-39.1%	$115K
Accounts Receivable	$95K+82.7%	$52K-37.3%	$83K-6.7%	$89K-3.3%	$92K-20.0%	$115K+43.8%	$80K+19.4%	$67K
Goodwill	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Total Liabilities	$51.5M-15.7%	$61.1M+43.6%	$42.5M+0.8%	$42.2M-2.4%	$43.2M+48.5%	$29.1M+3.0%	$28.3M+11.1%	$25.4M
Current Liabilities	$16.7M-19.0%	$20.7M+21.1%	$17.1M+10.1%	$15.5M-4.4%	$16.2M-0.1%	$16.2M+11.8%	$14.5M+39.2%	$10.4M
Long-Term Debt	$15.0M0.0%	$15.0M0.0%	$15.0M0.0%	$15.0M0.0%	$15.0M	N/A	N/A	N/A
Total Equity	$53.6M+22.5%	$43.7M+14726.8%	$295K-98.2%	$16.9M-48.9%	$33.0M-28.7%	$46.2M+4.7%	$44.1M-22.8%	$57.2M
Retained Earnings	-$362.6M+1.7%	-$368.8M-6.0%	-$348.0M-5.9%	-$328.6M-6.1%	-$309.9M-5.5%	-$293.7M-5.5%	-$278.3M-6.1%	-$262.3M

OBIO Cash Flow Statement

Metric	FY25	FY24	FY23	FY22	FY21
Operating Cash Flow	-$49.0M+3.2%	-$50.6M-9.6%	-$46.1M-57.5%	-$29.3M-10653.7%	-$272K
Capital Expenditures	$489K+69.2%	$289K+270.5%	$78K-86.8%	$591K	N/A
Free Cash Flow	-$49.5M+2.7%	-$50.8M-10.0%	-$46.2M-54.6%	-$29.9M	N/A
Investing Cash Flow	-$26.9M-305.8%	$13.1M+22.5%	$10.7M+116.7%	-$64.1M	N/A
Financing Cash Flow	$88.3M+202.8%	$29.2M-36.9%	$46.2M-55.2%	$103.3M	N/A
Dividends Paid	N/A	N/A	N/A	N/A	N/A
Share Buybacks	N/A	N/A	N/A	N/A	N/A

Metric	Q4'25	Q3'25	Q2'25	Q1'25	Q4'24	Q3'24	Q2'24	Q1'24
Operating Cash Flow	-$2.3M+84.4%	-$14.6M+6.3%	-$15.5M+6.6%	-$16.6M-22.7%	-$13.5M+1.2%	-$13.7M-34.2%	-$10.2M+22.2%	-$13.1M
Capital Expenditures	$33K-89.4%	$310K+811.8%	$34K-69.6%	$112K+5.7%	$106K+55.9%	$68K-36.4%	$107K+1237.5%	$8K
Free Cash Flow	-$2.3M+84.5%	-$14.9M+4.5%	-$15.6M+7.0%	-$16.7M-22.6%	-$13.6M+0.9%	-$13.8M-33.5%	-$10.3M+21.4%	-$13.1M
Investing Cash Flow	-$17.7M+54.1%	-$38.6M-335.9%	$16.4M+25.8%	$13.0M+446.4%	-$3.8M-773.8%	$557K-94.7%	$10.4M+77.9%	$5.9M
Financing Cash Flow	$12.7M-83.4%	$76.4M+17949.8%	-$428K-44.6%	-$296K-102.1%	$13.9M-7.2%	$15.0M+8692.4%	$171K+850.0%	$18K
Dividends Paid	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Share Buybacks	N/A	N/A	N/A	N/A	N/A	N/A	N/A	N/A

OBIO Financial Ratios

Metric	FY25	FY24	FY23	FY22	FY21
Gross Margin	99.4%+7.2pp	92.3%-1.0pp	93.3%-0.8pp	94.0%	N/A
Operating Margin	-154.7%+2282.8pp	-2437.5%-571.3pp	-1866.2%-941.8pp	-924.3%	N/A
Net Margin	-157.4%+2155.9pp	-2313.3%-533.6pp	-1779.7%-828.4pp	-951.3%	N/A
Return on Equity	-98.4%+86.8pp	-185.2%-113.0pp	-72.2%-8.2pp	-64.0%	N/A
Return on Assets	-45.9%+34.2pp	-80.1%-28.5pp	-51.6%-16.4pp	-35.2%-34.9pp	-0.2%
Current Ratio	6.45+2.2	4.27-3.7	7.95+3.4	4.56-6.3	10.88
Debt-to-Equity	0.28-0.2	0.46+0.1	0.40-0.4	0.82+10.0	-9.18
FCF Margin	-147.7%+1779.8pp	-1927.5%-253.4pp	-1674.1%-828.4pp	-845.7%	N/A

Metric	Q4'25	Q3'25	Q2'25	Q1'25	Q4'24	Q3'24	Q2'24	Q1'24
Gross Margin	99.8%+5.5pp	94.3%-0.2pp	94.5%-0.4pp	94.9%+17.8pp	77.1%-16.0pp	93.1%-1.2pp	94.3%-0.2pp	94.5%
Operating Margin	21.9%+2381.1pp	-2359.2%-47.4pp	-2311.8%-132.0pp	-2179.8%+4411.9pp	-6591.7%-4936.0pp	-1655.7%+511.2pp	-2167.0%+159.3pp	-2326.3%
Net Margin	20.2%+2439.3pp	-2419.1%-102.9pp	-2316.2%-155.4pp	-2160.7%+4224.7pp	-6385.4%-4822.5pp	-1562.9%+491.1pp	-2054.0%+117.5pp	-2171.5%
Return on Equity	11.7%+59.3pp	-47.6%+6516.1pp	-6563.7%-6452.5pp	-111.3%-62.2pp	-49.0%-15.6pp	-33.4%+2.8pp	-36.2%-12.7pp	-23.5%
Return on Assets	5.4%+25.3pp	-19.9%+25.3pp	-45.2%-13.5pp	-31.8%-10.5pp	-21.2%-0.7pp	-20.5%+1.6pp	-22.1%-5.8pp	-16.3%
Current Ratio	6.45+1.7	4.73+2.6	2.10-1.2	3.35-0.9	4.27+0.0	4.23-0.4	4.58-2.8	7.34
Debt-to-Equity	0.28-0.1	0.34-50.5	50.85+50.0	0.89+0.4	0.46-0.2	0.63-0.0	0.64+0.2	0.44
FCF Margin	-7.4%+1718.5pp	-1725.9%+135.5pp	-1861.4%+65.8pp	-1927.2%+3465.7pp	-5392.9%-3998.0pp	-1394.9%-69.3pp	-1325.6%+790.9pp	-2116.4%

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Frequently Asked Questions

What is Orchestra BioMed Holdings Inc's annual revenue?

Orchestra BioMed Holdings Inc (OBIO) reported $33.5M in total revenue for fiscal year 2025. This represents a 1169.2% change compared to the previous fiscal year. Revenue measures the total income earned from the company's primary business operations before any expenses are deducted.

How fast is Orchestra BioMed Holdings Inc's revenue growing?

Orchestra BioMed Holdings Inc (OBIO) revenue grew by 1169.2% year-over-year, from $2.6M to $33.5M in fiscal year 2025.

Is Orchestra BioMed Holdings Inc profitable?

No, Orchestra BioMed Holdings Inc (OBIO) reported a net income of -$52.7M in fiscal year 2025, with a net profit margin of -157.4%.

What is Orchestra BioMed Holdings Inc's EBITDA?

Orchestra BioMed Holdings Inc (OBIO) had EBITDA of -$51.5M in fiscal year 2025, measuring earnings before interest, taxes, depreciation, and amortization.

How much debt does Orchestra BioMed Holdings Inc have?

As of fiscal year 2025, Orchestra BioMed Holdings Inc (OBIO) had $34.7M in cash and equivalents against $15.0M in long-term debt.

What is Orchestra BioMed Holdings Inc's gross margin?

Orchestra BioMed Holdings Inc (OBIO) had a gross margin of 99.4% in fiscal year 2025, indicating the percentage of revenue retained after direct costs of goods sold.

What is Orchestra BioMed Holdings Inc's operating margin?

Orchestra BioMed Holdings Inc (OBIO) had an operating margin of -154.7% in fiscal year 2025, reflecting the profitability of core business operations before interest and taxes.

What is Orchestra BioMed Holdings Inc's net profit margin?

Orchestra BioMed Holdings Inc (OBIO) had a net profit margin of -157.4% in fiscal year 2025, representing the share of revenue converted into profit after all expenses.

What is Orchestra BioMed Holdings Inc's return on equity (ROE)?

Orchestra BioMed Holdings Inc (OBIO) has a return on equity of -98.4% for fiscal year 2025, measuring how efficiently the company generates profit from shareholder equity.

What is Orchestra BioMed Holdings Inc's free cash flow?

Orchestra BioMed Holdings Inc (OBIO) generated -$49.5M in free cash flow during fiscal year 2025. This represents a 2.7% change compared to the previous fiscal year. Free cash flow represents the cash a company generates after accounting for capital expenditures, and is widely used to assess financial flexibility and shareholder value.

What is Orchestra BioMed Holdings Inc's operating cash flow?

Orchestra BioMed Holdings Inc (OBIO) generated -$49.0M in operating cash flow during fiscal year 2025, representing cash generated from core business activities.

What are Orchestra BioMed Holdings Inc's total assets?

Orchestra BioMed Holdings Inc (OBIO) had $114.9M in total assets as of fiscal year 2025, including both current and long-term assets.

What are Orchestra BioMed Holdings Inc's capital expenditures?

Orchestra BioMed Holdings Inc (OBIO) invested $489K in capital expenditures during fiscal year 2025, funding long-term assets and infrastructure.

How much does Orchestra BioMed Holdings Inc spend on research and development?

Orchestra BioMed Holdings Inc (OBIO) invested $58.2M in research and development during fiscal year 2025.

How many shares does Orchestra BioMed Holdings Inc have outstanding?

Orchestra BioMed Holdings Inc (OBIO) had 57M shares outstanding as of fiscal year 2025.

What is Orchestra BioMed Holdings Inc's current ratio?

Orchestra BioMed Holdings Inc (OBIO) had a current ratio of 6.45 as of fiscal year 2025, which is generally considered healthy.

What is Orchestra BioMed Holdings Inc's debt-to-equity ratio?

Orchestra BioMed Holdings Inc (OBIO) had a debt-to-equity ratio of 0.28 as of fiscal year 2025, measuring the company's financial leverage by comparing total debt to shareholder equity.

What is Orchestra BioMed Holdings Inc's return on assets (ROA)?

Orchestra BioMed Holdings Inc (OBIO) had a return on assets of -45.9% for fiscal year 2025, measuring how efficiently the company uses its assets to generate profit.

What is Orchestra BioMed Holdings Inc's cash runway?

Based on fiscal year 2025 data, Orchestra BioMed Holdings Inc (OBIO) had $34.7M in cash against an annual operating cash burn of $49.0M. This gives an estimated cash runway of approximately 9 months at the current burn rate. Cash runway measures how long a company can continue operating before running out of cash, assuming no additional funding.

What is Orchestra BioMed Holdings Inc's Piotroski F-Score?

Orchestra BioMed Holdings Inc (OBIO) has a Piotroski F-Score of 6 out of 9, indicating neutral financial health. The F-Score evaluates nine binary signals across profitability (positive ROA, positive cash flow, improving ROA, earnings quality), leverage (decreasing debt, improving liquidity, no share dilution), and operating efficiency (improving gross margin, improving asset turnover). Scores of 7–9 indicate strong and improving fundamentals. Learn more in our complete guide to financial health indicators.

Are Orchestra BioMed Holdings Inc's earnings high quality?

Orchestra BioMed Holdings Inc (OBIO) has an earnings quality ratio of 0.93x, considered low quality (accrual-driven). This ratio compares operating cash flow to net income. A ratio above 1.0x means the company generates more cash than its reported earnings, indicating sustainable, cash-backed profits. Ratios below 1.0x suggest earnings rely on accounting accruals rather than actual cash generation. Learn more in our complete guide to financial health indicators.

How financially healthy is Orchestra BioMed Holdings Inc?

Orchestra BioMed Holdings Inc (OBIO) scores 49 out of 100 on our Financial Profile, indicating moderate overall financial health. This composite score evaluates six dimensions: profitability (operating margin), revenue growth, leverage (debt-to-equity), liquidity (current ratio), cash flow quality (free cash flow margin), and shareholder returns (return on equity). Each dimension is normalized against standard financial benchmarks. Learn more in our complete guide to financial health indicators.