Vor Bio Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Company Update
Vor Bio (Nasdaq: VOR) reports positive financial results for Q4 2023 and full year 2023, with a cash position of $137.2 million funding operations into the second half of 2025. Fast Track and Orphan Drug Designation granted to VCAR33ALLO by FDA. Multiple patients to be dosed with VCAR33ALLO in 2024. Trem-cel and VCAR33ALLO clinical trial data expected in the second half of 2024.
Positive
Positive financial results for Q4 2023 and full year 2023.
Cash position of $137.2 million funding operations into the second half of 2025.
Fast Track and Orphan Drug Designation granted to VCAR33ALLO by FDA.
Multiple patients to be dosed with VCAR33ALLO in the first half of 2024.
Trem-cel and VCAR33ALLO clinical trial data expected in the second half of 2024.
The financial results from Vor Bio indicate a growing investment in research and development (R&D), with a year-on-year increase from $64.6 million to $94.3 million. This reflects the company's intensified efforts in advancing clinical trials and manufacturing processes, particularly for its AML treatments VCAR33ALLO and trem-cel. The increased R&D spending is a strategic move, aiming to bring innovative therapies to market, which could potentially lead to significant revenue streams upon successful commercialization.
However, the reported net loss widening from $92.1 million to $117.9 million raises concerns about the company's current burn rate. Investors should monitor the cash runway, which is projected to last into the second half of 2025, against the timelines for clinical data readouts and potential FDA approvals. The financial health of Vor Bio will be closely tied to these milestones, as positive clinical results and subsequent approvals can greatly enhance the company's valuation and attract further investments.
The Fast Track and Orphan Drug Designations granted to VCAR33ALLO by the FDA are significant endorsements, expediting the development process and offering a period of market exclusivity upon approval. This could position Vor Bio advantageously in the competitive landscape of AML treatments, assuming the clinical trial data supports efficacy and safety. The unique approach of using transplant donor-derived lymphocytes for CAR-T cell therapy is noteworthy, as it could potentially offer enhanced anti-leukemia activity and patient outcomes compared to traditional therapies.
For stakeholders, the upcoming clinical data readouts in the second half of 2024 are pivotal. Success in these trials could lead to a surge in investor confidence and a higher stock valuation. Conversely, any setbacks could have a detrimental impact on the company's financial position and stock price. Long-term, if Vor Bio's therapies prove effective, this could revolutionize treatment options for AML patients and create a new standard of care, substantially impacting the oncology market.
AML remains an area with significant unmet medical needs and Vor Bio's focus on innovative CAR-T therapies places it within a high-growth potential market. The company's strategic approach to target both CD33 and CLL-1 antigens, coupled with its multiplex engineering of hematopoietic stem cells, indicates a forward-thinking stance that could differentiate it from competitors. These advancements could capture a sizable market share if the therapies are approved and commercialized.
Investors should consider the broader impact of Vor Bio's pipeline on the biotech sector. Success could spur further investment in similar technologies and companies, while failure could cast doubt on the viability of similar approaches. The biotech industry often moves based on perceived potential and Vor Bio's progress or lack thereof will likely influence peer companies and the investment landscape.
03/20/2024 - 04:05 PM
Trem-cel and VCAR33 ALLO clinical trial data expected in the second half of 2024 VCAR33 ALLO granted Fast Track and Orphan Drug Designation by U.S. Food & Drug Administration Cash runway extends into second half of 2025 CAMBRIDGE, Mass., March 20, 2024 (GLOBE NEWSWIRE) -- Vor Bio (Nasdaq: VOR), a clinical-stage cell and genome engineering company, today reported financial results for the three-month period and full year ended December 31, 2023, and provided a business update.
“We are very pleased with the foundational progress we made in 2023. Building on this, we expect 2024 to be an exciting year in which we demonstrate the Vor Bio approach to be instrumental in reducing the disease burden of AML, a devastating cancer where we desperately need effective treatment options,” said Dr. Robert Ang, Vor Bio’s President and Chief Executive Officer.
Corporate Updates
Multiple patients expected to be dosed with VCAR33 ALLO in the first half of 2024; initial data anticipated in second half of 2024
VBP301, a Phase 1/2, multicenter, open-label, first-in-human study of VCAR33ALLO , is a transplant donor-derived anti-CD33 CAR-T cell therapy for patients with AML who have relapsed following a standard-of-care or trem-cel transplant. The first patient was dosed in January 2024, and multiple patients are expected to be dosed in the first half of 2024. We anticipate initial data in the second half of 2024. The U.S. Food & Drug Administration (FDA) has granted Fast Track Designation and Orphan Drug Designation to VCAR33ALLO . The FDA Fast Track process aims to facilitate the development and expedite the review of drugs that treat serious conditions and fill an unmet medical need. Orphan Drug Designation entitles companies to development incentives including tax credits for clinical testing, prescription drug user fee exemptions and seven-year marketing exclusivity in the event of regulatory approval. VCAR33ALLO is manufactured from lymphocytes collected from the patient’s original transplant donor, generating a CAR-T cell therapy that is exactly matched to the recipient’s engrafted blood system. By using healthy transplant donor cells as the starting material to produce VCAR33ALLO , the CAR-T cells have a more stem-like phenotype, leading to greater potential for expansion, persistence, and anti-leukemia activity compared to a product derived from a patient’s own lymphocytes.
VBP101 clinical trial of trem-cel enrolling steadily, with the next data readout expected in the second half of 2024
Dose escalation of Mylotarg to 1.0 mg/m2 has commenced with multiple patients now treated. Patients receiving a trem-cel transplant who become measurable residual disease (MRD) positive or relapse have the option to receive induction-course Mylotarg or VCAR33ALLO . The Company expects to report further engraftment and protection data from the VBP101 clinical trial in the second half of 2024. The latest data update from VBP101, the Phase 1/2a clinical study of trem-cel, was presented at the ASH Annual Meeting on December 10, 2023, showing primary neutrophil engraftment in all eight patients and hematologic protection from acute Mylotarg toxicity through repeat doses. Trem-cel is a shielded transplant in development for patients with AML, in which healthy transplant donor cells are genetically engineered by removing CD33, with the potential to enable targeted therapies such as Mylotarg and CD33-targeted CAR-T therapy post-transplant, while avoiding on-target toxicities.
Continued progress on dual-targeted CAR-T and multiplex engineering approach
The Company continues to make progress with a dual-specific CAR-T targeting CD33 and CLL-1, two of the most promising antigens in AML. This is being paired with a hematopoietic stem cell (HSC) multiplex engineering approach, which could allow removal or modification of these two genes. The Company has demonstrated in vitro proof of concept for this approach.
IND-enabling work is progressing for the Company’s dual-specific CAR-T with key in vivo proof-of-concept experiments underway.
Upcoming Milestones
Trem-cel clinical data update expected in the second half of 2024 VCAR33ALLO clinical data update expected in the second half of 2024 Fourth Quarter and Full Year 2023 Financial Results
Cash Position: Cash, cash equivalents and marketable securities were $137.2 million as of December 31, 2023, which is projected to fund operations into the second half of 2025. Research & Development (R&D) Expenses: R&D expenses for the fourth quarter of 2023 were $20.9 million , compared to $17.1 million for the fourth quarter of 2022, and for the year ended December 31, 2023, were $94.3 million , compared to $64.6 million for the year ended December 31, 2022. The increase in R&D expenses was attributable primarily to an increase in clinical trial, manufacturing and personnel expenses, and the execution of our non-exclusive license agreement with Editas Medicine.General & Administrative (G&A) Expenses: G&A expenses for the fourth quarter of 2023 were $7.2 million , compared to $7.7 million for the fourth quarter of 2022, and for the year ended December 31, 2023, were $31.7 million , compared to $28.9 million for the year ended December 31, 2022. The increase in G&A expenses was primarily attributable to an increase in personnel expenses, including an increase in share-based compensation expense.Net Loss: Net loss for the fourth quarter of 2023 was $26.3 million , compared to $23.9 million for the fourth quarter of 2022, and for the year ended December 31, 2023, was $117.9 million , compared to $92.1 million for the year ended December 31, 2022.About Vor Bio www.vorbio.com .
Forward-Looking Statements ALLO in combination with trem-cel as a Treatment System, its potential upcoming milestones, its cash runway and expected capital requirements. Vor Bio may not actually achieve the plans, intentions, or expectations disclosed in these forward-looking statements, and you should not place undue reliance on these forward-looking statements. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various factors, including: uncertainties inherent in the initiation and completion of preclinical studies and clinical trials and clinical development of Vor Bio’s product candidates; availability and timing of results from preclinical studies and clinical trials; whether interim results from a clinical trial will be predictive of the final results of the trial or the results of future trials; expectations for regulatory approvals to conduct trials or to market products; the success of Vor Bio’s in-house manufacturing capabilities and efforts; and availability of funding sufficient for its foreseeable and unforeseeable operating expenses and capital expenditure requirements. These and other risks are described in greater detail under the caption “Risk Factors” included in Vor Bio’s most recent annual or quarterly report and in other reports it has filed or may file with the Securities and Exchange Commission. Any forward-looking statements contained in this press release speak only as of the date hereof, and Vor Bio expressly disclaims any obligation to update any forward-looking statements, whether because of new information, future events or otherwise, except as may be required by law.
Condensed Consolidated Balance Sheet Data (in thousands) December 31, December 31, 2023 2022 Cash, cash equivalents and marketable securities $ 137,175 $ 230,245 Total assets 198,126 299,366 Total liabilities 47,402 48,759 Total stockholders' equity 150,724 250,607 Consolidated Statement of Operations (in thousands, except share and per share data) Three Months Ended Twelve Months Ended December 31, December 31, 2023 2022 2023 2022 Operating expenses: Research and development $ 20,897 $ 17,062 $ 94,315 $ 64,550 General and administrative 7,227 7,663 31,721 28,868 Total operating expenses $ 28,124 $ 24,725 $ 126,036 $ 93,418 Loss from operations $ (28,124 ) $ (24,725 ) $ (126,036 ) $ (93,418 ) Other income: Interest income 1,863 814 8,173 1,324 Total other income 1,863 814 8,173 1,324 Net loss $ (26,261 ) $ (23,911 ) $ (117,863 ) $ (92,094 ) Net loss per share attributable to common stockholders, basic and diluted $ (0.39 ) $ (0.53 ) $ (1.75 ) $ (2.33 ) Weighted-average common shares outstanding, basic and diluted 67,839,463 45,394,089 67,191,973 39,551,420
Contact: sspencer@vorbio.com
What are Vor Bio's ticker symbol and the recent financial results reported?
Vor Bio's ticker symbol is VOR, and the recent financial results reported are positive for Q4 2023 and full year 2023.
What is the cash position of Vor Bio as of December 31, 2023, and how long is it projected to fund operations?
Vor Bio's cash, cash equivalents, and marketable securities were $137.2 million as of December 31, 2023, projected to fund operations into the second half of 2025.
What designations were granted to VCAR33ALLO by the FDA?
VCAR33ALLO was granted Fast Track and Orphan Drug Designation by the FDA.
When are multiple patients expected to be dosed with VCAR33ALLO, and when is the initial data anticipated?
Multiple patients are expected to be dosed with VCAR33ALLO in the first half of 2024, with initial data anticipated in the second half of 2024.
When is the expected timeline for Trem-cel and VCAR33ALLO clinical trial data?
Trem-cel and VCAR33ALLO clinical trial data are expected in the second half of 2024.
