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MARKET LEADERS
52-WEEK LEADER
BW +3108%
Babcock & Wilcox Enter..
2022 YTD LEADER
BEAG +9999%
Bold Eagle Acquisition..
DEC 2022 LEADER
RGC +3541%
Regencell Bioscience H..
📈 52-Week Top 5 Full List →
1 BW +3108.2% 2 BE +1613.1% 3 PL +917.3% 4 AMPX +828.8% 5 WOLF +611.9%
📅 2022 YTD Top 5 Full List →
1 BEAG +9999.0% 2 SNWV +9670.6% 3 META +4287.7% 4 RGC +3492.7% 5 CLS +3259.0%
🗓 December 2022 Top 5 Full List →
1 RGC +3541.0% 2 KALA +626.7% 3 SMMT +524.9% 4 PHVS +438.3% 5 MDGL +296.9%
Quick Access: 52-Week 2022 YTD Dec 2022 Market Cap Dividends
#1 RGC leads with +3,541% December 2022

RGC (Regencell Bioscience Holdings Limited) is the best performing stock in December 2022. Following are KALA (+627%) and SMMT (+525%). Top performing sectors: Healthcare (+161% avg, 7 in top 10), Financial Services (+68% avg, 1 in top 10), Consumer Defensive (+65% avg).

Top Stock Gainers December 2022 - Monthly Performance Ranked

Track the top performing stocks of December 2022 ranked by monthly price gain. See which stock gainers delivered the highest gains this month, with market caps over $100 million on Nasdaq and NYSE.
2022
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec

This ranking shows the top performing stocks and biggest stock gainers during December 2022, calculated from the first to the last trading day of the month. It shows which stocks are going up this month, with split-adjusted data used for consistent performance calculations.

Monthly performance rankings can reveal price strength, sustained momentum, sector rotation, and event-driven moves that are not visible in one-day movers lists. The table is informational only and does not recommend any stock to buy, sell, or hold.

December 2022 Stock Market Momentum

This page answers a current-month trend question with data: which NYSE and NASDAQ stocks have shown the strongest price gains so far in December 2022. The ranking is based on observed market performance, not analyst ratings, price targets, or investment recommendations.

Use the list to research momentum, market breadth, sector strength, and catalysts behind large moves. Before acting on any stock, review the company's news, SEC filings, liquidity, volatility, and your own risk constraints.

Looking for a specific Symbol?

Data as of April 30, 2026 at 2:43 PM EDT

Rank
Symbol
Company Name
Dec Gain
Market Cap
Price
Country
Sector
1
RGC
Regencell Bioscience Holdin...
3540.99%
14.36 B
$ 29.05
Hong Kong
Healthcare
2
KALA
KALA BIO, Inc.
626.67%
101.69 M
$ 0.1094
United States
Healthcare
3
SMMT
Summit Therapeutics Inc.
524.91%
16.50 B
$ 21.26
United States
Healthcare
4
PHVS
Pharvaris N.V.
438.28%
1.85 B
$ 28.22
Switzerland
Healthcare
5
MDGL
Madrigal Pharmaceuticals, Inc.
296.95%
11.90 B
$ 518.58
United States
Healthcare
6
ACIC
American Coastal Insurance ...
231.25%
572.86 M
$ 11.85
United States
Financial Services
7
GOAI
Eva Live, Inc.
221.6%
143.58 M
$ 3.93
United States
Technology
8
PRQR
ProQR Therapeutics N.V.
203.28%
155.93 M
$ 1.48
Netherlands
Healthcare
9
VKTX
Viking Therapeutics, Inc.
127.6%
3.75 B
$ 32.39
United States
Healthcare
10
RENT
Rent the Runway, Inc.
122.63%
156.33 M
$ 4.66
United States
Consumer Cyclical
11
MSC
Studio City International H...
120.74%
485.32 M
$ 2.52
Hong Kong
Consumer Cyclical
12
PROF
Profound Medical Corp.
120%
243.17 M
$ 6.7
Canada
Healthcare
13
RIGL
Rigel Pharmaceuticals, Inc.
119.27%
564.75 M
$ 30.56
United States
Healthcare
14
WDH
Waterdrop Inc.
105.56%
623.51 M
$ 1.69
China
Financial Services
15
RNA
Atrium Therapeutics, Inc.
99.73%
194.71 M
$ 12.55
United States
Healthcare
16
CABA
Cabaletta Bio, Inc.
97.65%
309.48 M
$ 2.78
United States
Healthcare
17
AKBA
Akebia Therapeutics, Inc.
97.54%
364.32 M
$ 1.36
United States
Healthcare
18
IMMX
Immix Biopharma, Inc.
97.43%
457.49 M
$ 8.63
United States
Healthcare
19
SLNO
Soleno Therapeutics, Inc.
96.04%
2.73 B
$ 52.76
United States
Healthcare
20
VRNA
Verona Pharma plc
90.59%
9.04 B
$ 106.4
United Kingdom
Healthcare
21
GOTU
Gaotu Techedu Inc.
87.3%
443.52 M
$ 1.86
China
Consumer Defensive
22
IQ
iQIYI, Inc.
82.13%
1.12 B
$ 1.16
China
Communication Services
23
EH
EHang Holdings Limited
80.25%
668.02 M
$ 9.28
China
Industrials
24
MAMA
Mama's Creations, Inc.
79.5%
554.97 M
$ 13.65
United States
Consumer Defensive
25
TUYA
Tuya Inc.
73.64%
1.39 B
$ 2.28
China
Technology
26
KRRO
Korro Bio, Inc.
71.88%
181.87 M
$ 12.61
United States
Healthcare
27
CELC
Celcuity Inc.
71.69%
5.75 B
$ 119
United States
Healthcare
28
MOMO
Hello Group Inc.
64.17%
896.83 M
$ 6.07
China
Communication Services
29
IPHA
Innate Pharma S.A.
62.88%
138.87 M
$ 1.48
France
Healthcare
30
ARDX
Ardelyx, Inc.
62.86%
1.47 B
$ 6.01
United States
Healthcare
31
ALVO
Alvotech
62.6%
1.03 B
$ 3.3
Luxembourg
Healthcare
32
WVE
Wave Life Sciences Ltd.
60.92%
1.45 B
$ 7.52
Singapore
Healthcare
33
SY
So-Young International Inc.
60.55%
286.85 M
$ 2.86
China
Healthcare
34
ACLX
Arcellx, Inc.
57.26%
6.73 B
$ 115.05
United States
Healthcare
35
TUSK
Mammoth Energy Services, Inc.
55.58%
136.37 M
$ 2.82
United States
Industrials
36
RERE
ATRenew Inc.
55.38%
992.28 M
$ 4.48
China
Consumer Cyclical
37
VATE
INNOVATE Corp.
54.55%
168.37 M
$ 12.33
United States
Industrials
38
ETNB
89bio, Inc.
54.12%
1.28 B
$ 8.65
United States
Healthcare
39
ALT
Altimmune, Inc.
52.46%
511.15 M
$ 2.63
United States
Healthcare
40
PMTS
CPI Card Group Inc.
49.4%
208.12 M
$ 18.16
United States
Financial Services
41
HUYA
HUYA Inc.
47.94%
703.16 M
$ 3.06
China
Communication Services
42
TGTX
TG Therapeutics, Inc.
47.51%
5.52 B
$ 34.58
United States
Healthcare
43
TERN
Terns Pharmaceuticals, Inc.
46.05%
6.12 B
$ 52.94
United States
Healthcare
44
ORIC
ORIC Pharmaceuticals, Inc.
45.79%
1.08 B
$ 9.65
United States
Healthcare
45
ORMP
Oramed Pharmaceuticals Inc.
44.24%
163.00 M
$ 4.03
United States
Healthcare
46
PLSE
Pulse Biosciences, Inc.
43.52%
1.48 B
$ 21.83
United States
Healthcare
47
ASRT
Assertio Holdings, Inc.
43.33%
116.52 M
$ 18.05
United States
Healthcare
48
EOSE
Eos Energy Enterprises, Inc.
42.31%
2.15 B
$ 6.34
United States
Industrials
49
SOUN
SoundHound AI, Inc.
41.6%
3.44 B
$ 8.06
United States
Technology
50
KINS
Kingstone Companies, Inc.
40.64%
245.38 M
$ 16.95
United States
Financial Services
51
VOR
Vor Biopharma Inc.
40%
702.43 M
$ 14.38
United States
Healthcare
52
PTGX
Protagonist Therapeutics, Inc.
39.87%
6.46 B
$ 101.21
United States
Healthcare
53
BILI
Bilibili Inc.
39.19%
8.94 B
$ 21.46
China
Communication Services
54
GDS
GDS Holdings Limited
38.67%
8.32 B
$ 41.54
China
Technology
55
XYF
X Financial
38.53%
192.30 M
$ 4.92
China
Financial Services
56
SGU
Star Group, L.P.
38.19%
414.60 M
$ 12.61
United States
Energy
57
ROIV
Roivant Sciences Ltd.
37.76%
19.88 B
$ 27.77
United Kingdom
Healthcare
58
NINE
Nine Energy Service, Inc.
37.59%
128.34 M
$ 9.2
United States
Energy
59
BLZE
Backblaze, Inc.
37.28%
250.86 M
$ 4.18
United States
Technology
60
EVER
EverQuote, Inc.
36.48%
557.48 M
$ 15.76
United States
Communication Services
61
REPL
Replimune Group, Inc.
36.14%
212.21 M
$ 2.57
United States
Healthcare
62
NIU
Niu Technologies
35.49%
236.88 M
$ 3.02
China
Consumer Cyclical
63
ATXS
Astria Therapeutics, Inc.
35.36%
718.13 M
$ 12.58
United States
Healthcare
64
UAMY
United States Antimony Corp...
35.17%
1.55 B
$ 10.81
United States
Basic Materials
65
PALI
Palisade Bio, Inc.
35.06%
326.86 M
$ 1.95
United States
Healthcare
66
POWL
Powell Industries, Inc.
33.97%
9.31 B
$ 255.56
United States
Industrials
67
BWAY
BrainsWay Ltd.
33.51%
635.72 M
$ 15.88
Israel
Healthcare
68
API
Agora, Inc.
32.99%
296.77 M
$ 3.51
United States
Technology
69
DRS
Leonardo DRS, Inc.
32.57%
10.50 B
$ 39.47
United States
Industrials
70
MFH
Mercurity Fintech Holding Inc.
32.41%
510.48 M
$ 7.39
United States
Technology
71
CPS
Cooper-Standard Holdings Inc.
31.88%
514.90 M
$ 29
United States
Consumer Cyclical
72
DMAC
DiaMedica Therapeutics Inc.
31.68%
321.14 M
$ 5.96
United States
Healthcare
73
SPRY
ARS Pharmaceuticals, Inc.
31.64%
788.42 M
$ 7.94
United States
Healthcare
74
KC
Kingsoft Cloud Holdings Lim...
31.62%
4.46 B
$ 14.89
China
Technology
75
MLCO
Melco Resorts & Entertainme...
31.43%
2.24 B
$ 5.5
Hong Kong
Consumer Cyclical
76
GBTG
Global Business Travel Grou...
31.07%
3.01 B
$ 5.76
United Kingdom
Consumer Cyclical
77
TCMD
Tactile Systems Technology,...
30.6%
536.23 M
$ 23.57
United States
Healthcare
78
LRMR
Larimar Therapeutics, Inc.
30.28%
450.85 M
$ 4.34
United States
Healthcare
79
PPTA
Perpetua Resources Corp.
29.78%
3.44 B
$ 27.49
United States
Basic Materials
80
TAL
TAL Education Group
28.88%
6.55 B
$ 10.77
China
Consumer Defensive
81
CYH
Community Health Systems, Inc.
28.19%
404.43 M
$ 2.87
United States
Healthcare
82
QFIN
Qfin Holdings, Inc.
28.05%
1.58 B
$ 12.97
China
Financial Services
83
IMVT
Immunovant, Inc.
27.97%
5.49 B
$ 26.95
United States
Healthcare
84
RZLT
Rezolute, Inc.
27.78%
293.79 M
$ 3.07
United States
Healthcare
85
ZH
Zhihu Inc.
27.45%
287.28 M
$ 3.31
China
Communication Services
86
CVRX
CVRx, Inc.
27.25%
180.76 M
$ 6.87
United States
Healthcare
87
ARWR
Arrowhead Pharmaceuticals, ...
26.67%
9.88 B
$ 70.53
United States
Healthcare
88
KALV
KalVista Pharmaceuticals, Inc.
26.59%
1.37 B
$ 26.67
United States
Healthcare
89
SMWB
Similarweb Ltd.
26.57%
236.52 M
$ 2.7
Israel
Technology
90
APYX
Apyx Medical Corporation
26.49%
144.73 M
$ 3.46
United States
Healthcare
91
REKR
Rekor Systems, Inc.
26.3%
111.69 M
$ 0.8178
United States
Technology
92
FRGE
Forge Global Holdings Inc
26.28%
623.01 M
$ 45
United States
Financial Services
93
WB
Weibo Corporation
26.2%
2.00 B
$ 8.14
China
Communication Services
94
MG
Mistras Group, Inc.
26.09%
588.29 M
$ 18.49
United States
Industrials
95
STOK
Stoke Therapeutics, Inc.
25.92%
1.97 B
$ 33.33
United States
Healthcare
96
NRP
Natural Resource Partners L.P.
25.91%
1.55 B
$ 117.13
United States
Energy
97
DLO
DLocal Limited
25.67%
3.95 B
$ 13.4
Uruguay
Technology
98
IOT
Samsara Inc.
25.56%
17.06 B
$ 29.37
United States
Technology
99
OPOF
Old Point Financial Corpora...
25.46%
214.80 M
$ 42.1
United States
Financial Services
100
CTLP
Cantaloupe, Inc.
25.36%
801.34 M
$ 10.87
United States
Technology
For the most accurate results, consider cross-referencing our data with other sources.

Frequently Asked Questions

Q Which stock has gained the most in December 2022?
A

RGC (Regencell Bioscience Holdings Limited) has the highest monthly gain in this ranking for December 2022, with a gain of 3,541%. Top performers this month include RGC, KALA, SMMT.

Q What stocks gained the most in December 2022?
A

The biggest gainers in December 2022 were: RGC (+3,541%), KALA (+627%), SMMT (+525%), PHVS (+438%), MDGL (+297%). These monthly rankings show which stocks had the strongest short-term momentum.

Q Does this page recommend the best stocks to buy now?
A

No. This page is an informational ranking of stocks that have already gone up during December 2022. It does not make buy, sell, or hold recommendations and should be used as a research starting point, not financial advice.

Q How can this ranking help explain current stock market trends?
A

The ranking shows where price strength is concentrated during December 2022. Comparing the top gainers by sector, market cap, and recent catalysts can help identify momentum themes and market rotation without implying that any listed stock is a recommendation.

Q Which sectors performed best in December 2022?
A

The top performing sectors in December 2022 included Healthcare, based on the stocks with highest monthly gains. RGC led the Healthcare sector.

Q How is monthly stock performance calculated?
A

Monthly stock performance is calculated by comparing the closing price on the last trading day of the month to the opening price on the first trading day. Split-adjusted prices ensure accuracy.

Q Where can I find today's top stock gainers and most active stocks?
A

This page ranks stocks by their full-month performance in December 2022. For today's top stock gainers, real-time stock movers, and the most active stocks right now, visit our Momentum Scanner which tracks live intraday market activity across NYSE and NASDAQ.

Understanding Monthly Stock Performance

Monthly performance rankings reveal short-term momentum patterns and help identify stocks experiencing rapid price movements:

  • Momentum Research: Stocks showing strong monthly performance can help identify where market attention and price strength are concentrated.
  • Sector Rotation: Monthly rankings can reveal which sectors are gaining favor with investors and where market leadership is shifting.
  • Event-Driven Moves: Earnings releases, product launches, and regulatory approvals often create significant monthly price movements.

Using Monthly Data Effectively

  • Combine Timeframes: Compare monthly gainers with 52-week and YTD performance to identify stocks with both short and long-term momentum.
  • Research the Catalyst: Investigate why top monthly performers moved significantly. The reason for the move matters as much as the percentage gain.
  • Watch for Reversals: Extreme monthly gains sometimes precede corrections, so treat the ranking as a research starting point rather than a buy list.

Evaluate Your Positions

Researching one of this month's top movers? Use our Stock Return Calculator to review historical performance, or the Position Size Calculator to model position sizing and risk before making your own decision.