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Top Stock Gainers December 2022 - Monthly Performance Ranked

The top US-listed stocks of December 2022 by monthly gain, on split-adjusted closes. Ranks 3,421 companies above $100M on NYSE, Nasdaq and NYSE American.

Looking for intraday moves instead? Today's stock movers ranks the current session's alert board, so it measures against whichever session is running rather than covering a fixed window.

2022
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec

December 2022 ranking, complete through December 30, 2022

46 stocks are withheld from this ranking because their price history is under review.

The gain covers the period; price, market cap, sector and country show each company as it is today.

Swipe or scroll the table sideways for more columns.

Rank
Symbol
Company Name
Dec Gain
Market Cap (today)
Price (today)
Country
Sector
1
SMMT
Summit Therapeutics Inc
+524.91%
$10.50B
$13.16
United States
Healthcare
2
PHVS
Pharvaris N.V.
+438.28%
$2.55B
$36.27
Switzerland
Healthcare
3
MDGL
Madrigal Pharmac
+296.95%
$11.94B
$516.74
United States
Healthcare
4
ACIC
American Coastal Insurance
+231.25%
$433.93M
$9.18
United States
Financial Services
5
PRQR
Proqr Therapeuti
+203.28%
$330.22M
$2.34
Netherlands
Healthcare
6
XHG
XChange TEC
+182.11%
$227.33M
$4.41
China
Financial Services
7
VKTX
Viking Therapeutics Inc
+127.60%
$3.95B
$33.89
United States
Healthcare
8
RENT
Rent The Runway, Inc.
+122.63%
$127.63M
$3.80
United States
Consumer Cyclical
9
MSC
Studio City International H...
+120.74%
$357.25M
$1.85
Hong Kong
Consumer Cyclical
10
PROF
Profound Med Corp
+120.00%
$248.06M
$6.79
Canada
Healthcare
11
RIGL
Rigel Pharmaceuticals Inc
+119.27%
$857.22M
$45.89
United States
Healthcare
12
WDH
Waterdrop Inc
+105.56%
$359.30M
$1.00
China
Financial Services
13
RNA
Atrium Therapeutics, Inc
+99.73%
$225.79M
$13.20
United States
Healthcare
14
CABA
Cabaletta Bio, Inc.
+97.65%
$530.68M
$3.13
United States
Healthcare
15
AKBA
Akebia Therapeut
+97.54%
$251.22M
$0.9066
United States
Healthcare
16
IMMX
Immix Biopharma Inc
+97.43%
$972.45M
$13.66
United States
Healthcare
17
SLNO
Soleno Therapeutics Inc
+96.04%
$2.76B
$53.01
United States
Healthcare
18
VRNA
Verona Pharma
+90.59%
$9.04B
$106.40
United Kingdom
Healthcare
19
GOTU
Gaotu Techedu Inc
+87.30%
$400.60M
$1.68
China
Consumer Defensive
20
IQ
Iqiyi
+82.13%
$1.02B
$1.05
China
Communication Services
21
EH
Ehang Holdings Ltd
+80.25%
$417.91M
$5.51
China
Industrials
22
MAMA
Mama's Creations Inc
+79.50%
$764.42M
$16.44
United States
Consumer Defensive
23
TUYA
Tuya Inc
+73.64%
$1.10B
$1.80
China
Technology
24
KRRO
Korro Bio, Inc.
+71.88%
$194.08M
$13.18
United States
Healthcare
25
CELC
Celcuity Inc
+71.69%
$4.58B
$93.53
United States
Healthcare
26
MOMO
Hello Group Inc
+64.17%
$849.55M
$5.75
China
Communication Services
27
IPHA
Innate Pharma Sa
+62.88%
$252.44M
$2.26
France
Healthcare
28
ARDX
Ardelyx
+62.86%
$1.00B
$3.89
United States
Healthcare
29
ALVO
Alvotech
+62.60%
$1.50B
$4.43
Luxembourg
Healthcare
30
WVE
Wave Life Scienc
+60.92%
$1.04B
$5.29
United States
Healthcare
31
SY
So-Young Intl
+60.55%
$229.87M
$2.29
China
Healthcare
32
ACLX
ARCELLX INC
+57.26%
$6.73B
$115.07
United States
Healthcare
33
TUSK
Mammoth Energy Svcs Inc
+55.58%
$147.27M
$3.06
United States
Industrials
34
RERE
ATRENEW INC
+55.38%
$921.40M
$4.16
China
Consumer Cyclical
35
VATE
Innovate Corp
+54.55%
$107.23M
$7.86
United States
Industrials
36
ETNB
89Bio, Inc.
+54.12%
$1.28B
$8.65
United States
Healthcare
37
BDSX
BIODESIX INC
+53.33%
$280.98M
$26.63
United States
Healthcare
38
ALT
Altimmune
+52.46%
$604.95M
$3.11
United States
Healthcare
39
PMTS
CPI Card Group Inc.
+49.40%
$323.32M
$28.04
United States
Financial Services
40
HUYA
Huya Inc
+47.94%
$497.84M
$2.18
China
Communication Services
41
TGTX
Tg Therapeutics Inc
+47.51%
$8.31B
$54.27
United States
Healthcare
42
TERN
Terns Pharmaceuticals, Inc.
+46.05%
$6.12B
$52.95
United States
Healthcare
43
ORIC
Oric Pharmaceuticals, Inc.
+45.79%
$1.47B
$14.20
United States
Healthcare
44
ORMP
Oramed Pharmaceuticals Inc
+44.24%
$200.08M
$4.81
United States
Healthcare
45
PLSE
Pulse Biosciences Inc
+43.52%
$3.60B
$50.42
United States
Healthcare
46
ASRT
Assertio Holdings Inc
+43.33%
$151.86M
$23.50
United States
Healthcare
47
EOSE
Eos Energy Enterprises Inc
+42.31%
$1.38B
$3.81
United States
Industrials
48
SOUN
SOUNDHOUND AI INC
+41.60%
$3.25B
$7.32
United States
Technology
49
KINS
Kingstone
+40.64%
$287.06M
$19.83
United States
Financial Services
50
VOR
Vor Biopharma Inc.
+40.00%
$1.38B
$23.36
United States
Healthcare
51
PTGX
Protagonist Ther
+39.87%
$9.99B
$154.32
United States
Healthcare
52
BILI
Bilibili
+39.19%
$7.14B
$17.06
China
Communication Services
53
GDS
Gds Holdings Limited
+38.67%
$6.58B
$32.85
China
Technology
54
XYF
X Financial
+38.53%
$207.60M
$5.39
China
Financial Services
55
SGU
Star Group
+38.19%
$412.77M
$12.58
United States
Energy
56
ROIV
Roivant Sciences
+37.76%
$26.22B
$36.30
United Kingdom
Healthcare
57
NINE
NINE ENERGY SVC
+37.59%
$161.12M
$11.55
United States
Energy
58
BLZE
Backblaze, Inc.
+37.28%
$978.02M
$15.80
United States
Technology
59
EVER
Everquote
+36.48%
$889.45M
$25.24
United States
Communication Services
60
REPL
Replimune Group
+36.14%
$1.39B
$14.77
United States
Healthcare
61
NIU
Niu Technologies
+35.49%
$152.95M
$1.95
China
Consumer Cyclical
62
ATXS
Astria Therapeutics Inc
+35.36%
$718.13M
$12.58
United States
Healthcare
63
UAMY
United States Antimony
+35.17%
$821.68M
$5.49
United States
Basic Materials
64
PALI
Palisade Bio Inc
+35.06%
$365.97M
$2.10
United States
Healthcare
65
POWL
Powell Inds
+33.97%
$7.20B
$197.67
United States
Industrials
66
BWAY
Brainsway Ltd.
+33.51%
$592.39M
$14.74
Israel
Healthcare
67
API
Agora, Inc.
+32.99%
$368.64M
$4.36
United States
Technology
68
DRS
Leonardo DRS, Inc.
+32.57%
$10.86B
$40.70
United States
Industrials
69
MFH
Mercurity Fintech Holding Inc
+32.41%
$510.48M
$7.39
United States
Technology
70
CPS
Cooper-Standard Holdings
+31.88%
$498.07M
$28.03
United States
Consumer Cyclical
71
DMAC
Diamedica Therapeutics Inc
+31.68%
$351.60M
$6.52
United States
Healthcare
72
SPRY
ARS Pharms
+31.64%
$547.46M
$5.50
United States
Healthcare
73
KC
Kingsoft Cloud Holdings Ltd
+31.62%
$3.33B
$11.14
China
Technology
74
MLCO
Melco Resorts And Entmnt Ltd
+31.43%
$2.09B
$5.49
Hong Kong
Consumer Cyclical
75
GBTG
Global Business Travel Grou...
+31.07%
$4.94B
$9.45
United Kingdom
Consumer Cyclical
76
TCMD
Tactile Systems
+30.60%
$539.58M
$23.82
United States
Healthcare
77
LRMR
Larimar Therapeutics Inc
+30.28%
$434.23M
$4.18
United States
Healthcare
78
PPTA
Perpetua Resources Corp
+29.78%
$3.21B
$25.70
United States
Basic Materials
79
CYH
Community Health Sys Inc
+28.19%
$424.44M
$3.01
United States
Healthcare
80
QFIN
Qfin Holdings, Inc.
+28.05%
$1.41B
$11.57
China
Financial Services
81
IMVT
Immunovant Inc
+27.97%
$9.16B
$44.37
United States
Healthcare
82
RZLT
Rezolute Inc
+27.78%
$490.13M
$5.09
United States
Healthcare
83
ZH
Zhihu Inc
+27.45%
$275.00M
$3.22
China
Communication Services
84
ARWR
Arrowhead Pharma
+26.67%
$12.30B
$87.11
United States
Healthcare
85
KALV
Kalvista Pharm
+26.59%
$1.44B
$27.00
United States
Healthcare
86
SMWB
Similarweb Ltd
+26.57%
$727.17M
$8.24
Israel
Technology
87
APYX
Apyx Medical Corporation
+26.49%
$131.43M
$3.12
United States
Healthcare
88
WB
Weibo
+26.20%
$1.73B
$7.03
China
Communication Services
89
MG
Mistras
+26.09%
$603.87M
$18.96
United States
Industrials
90
STOK
Stoke Therapeutics
+25.92%
$2.08B
$32.29
United States
Healthcare
91
DLO
Dlocal Ltd
+25.67%
$4.46B
$15.17
Uruguay
Technology
92
OPOF
Old Point Finl
+25.46%
$214.80M
$42.10
United States
Financial Services
93
CTLP
Cantaloupe Inc
+25.36%
$825.82M
$11.20
United States
Technology
94
MDWD
Mediwound
+25.14%
$170.54M
$13.21
Israel
Healthcare
95
DCTH
Delcath Sys
+25.00%
$594.74M
$17.14
United States
Healthcare
96
PLX
Protalix Biother
+24.55%
$191.76M
$2.38
United States
Healthcare
97
ADAG
Adagene Inc.
+24.41%
$265.61M
$4.02
China
Healthcare
98
COFS
Choiceone Finl Svcs Inc
+23.25%
$495.63M
$33.14
United States
Financial Services
99
NAMS
NewAmsterdam Pharma Company...
+23.16%
$3.26B
$27.87
Netherlands
Healthcare
100
WLFC
Willis Lease
+22.96%
$1.15B
$54.37
United States
Industrials
Top gain on this page +524.91% SMMT
Rows on this page 100 ranks 1–100
Page 1 of 35
Period December 2022 closed

Best performing large-cap stocks in December 2022

SMMT Summit Therapeutics Inc. +524.91% $10.50B
MDGL Madrigal Pharmaceuticals, Inc. +296.95% $11.94B
ROIV Roivant Sciences Ltd. +37.76% $26.22B
DRS Leonardo DRS, Inc. +32.57% $10.86B
ARWR Arrowhead Pharmaceuticals, ... +26.67% $12.30B

December 2022 Stock Market Momentum

This page answers a current-month trend question with data: which US-listed stocks have shown the strongest price gains so far in December 2022. The ranking is based on observed market performance, not analyst ratings, price targets, or investment recommendations.

Use the list to research momentum, market breadth, sector strength, and catalysts behind large moves. Before acting on any stock, review the company's news, SEC filings, liquidity, volatility, and your own risk constraints.

Looking for a specific Symbol?
#1 SMMT leads with +525% December 2022

Among the 3,421 NYSE, Nasdaq and NYSE American stocks currently eligible for this ranking, SMMT (Summit Therapeutics Inc) has the highest gain in December 2022 with +525%. Following are PHVS (+438%) and MDGL (+297%). Top performing sectors: Consumer Defensive (+83% avg), Financial Services (+80% avg, 2 in top 10), Healthcare (+76% avg, 6 in top 10).

MARKET LEADERS
52-WEEK LEADER
SNDK +3312%
SanDisk Corp
2022 YTD LEADER
NINE +1131%
NINE ENERGY SVC
DEC 2022 LEADER
SMMT +525%
Summit Therapeutics Inc
52-Week Top 5 Full List →
1 SNDK +3311.9% 2 MGRT +2754.7% 3 AXTI +2390.8% 4 ERAS +1008.8% 5 NUAI +899.0%
2022 YTD Top 5 Full List →
1 NINE +1131.4% 2 META +689.1% 3 INDV +557.1% 4 TUSK +348.2% 5 RDUS +319.0%
December 2022 Top 5 Full List →
1 SMMT +524.9% 2 PHVS +438.3% 3 MDGL +296.9% 4 ACIC +231.3% 5 PRQR +203.3%
Quick Access: 52-Week 2022 YTD Dec 2022 Market Cap Dividends

This ranking shows the top performing stocks and biggest stock gainers during December 2022, calculated from the first to the last trading day of the month. It shows which stocks are going up this month, with split-adjusted data used for consistent performance calculations.

Monthly performance rankings can reveal price strength, sustained momentum, sector rotation, and event-driven moves that are not visible in one-day movers lists. The table is informational only and does not recommend any stock to buy, sell, or hold.

Gains are computed on split-adjusted closes, so a split inside the month does not read as a move. This ranking is informational and is not investment advice.

Frequently Asked Questions

Q Which stock has gained the most in December 2022?
A

SMMT (Summit Therapeutics Inc) has the highest monthly gain in this ranking for December 2022, with a gain of 525%. Top performers this month include SMMT, PHVS, MDGL.

Q What stocks gained the most in December 2022?
A

The biggest gainers in December 2022 were: SMMT (+525%), PHVS (+438%), MDGL (+297%), ACIC (+231%), PRQR (+203%). These monthly rankings show which stocks had the strongest short-term momentum.

Q Does this page recommend the best stocks to buy now?
A

No. This page is an informational ranking of stocks that have already gone up during December 2022. It does not make buy, sell, or hold recommendations and should be used as a research starting point, not financial advice.

Q How can this ranking help explain current stock market trends?
A

The ranking shows where price strength is concentrated during December 2022. Comparing the top gainers by sector, market cap, and recent catalysts can help identify momentum themes and market rotation without implying that any listed stock is a recommendation.

Q Which companies does this ranking include?
A

3,421 companies with a market capitalization above $100 million traded on NYSE, Nasdaq and NYSE American, each with at least one trading day inside December 2022. One close inside the month is enough to qualify, so a company that listed during the month is ranked on the part of it that it traded.

Q Which sectors performed best in December 2022?
A

The top performing sectors in December 2022 included Healthcare, Financial Services, based on the stocks with highest monthly gains. SMMT led the Healthcare sector.

Q How is monthly stock performance calculated?
A

Monthly stock performance is calculated by comparing the closing price on the last trading day of the month to the opening price on the first trading day. Split-adjusted prices ensure accuracy.

Q Where can I find today's top stock gainers and most active stocks?
A

This page ranks stocks by their full-month performance in December 2022. For today's top stock gainers, real-time stock movers, and the most active stocks right now, visit our Momentum Scanner, which tracks live intraday activity across US-listed symbols.

Understanding Monthly Stock Performance

Monthly performance rankings reveal short-term momentum patterns and help identify stocks experiencing rapid price movements:

  • Momentum Research: Stocks showing strong monthly performance can help identify where market attention and price strength are concentrated.
  • Sector Rotation: Monthly rankings can reveal which sectors are gaining favor with investors and where market leadership is shifting.
  • Event-Driven Moves: Earnings releases, product launches, and regulatory approvals often create significant monthly price movements.

Using Monthly Data Effectively

  • Combine Timeframes: Compare monthly gainers with 52-week and YTD performance to identify stocks with both short and long-term momentum.
  • Research the Catalyst: Investigate why top monthly performers moved significantly. The reason for the move matters as much as the percentage gain.
  • Watch for Reversals: Extreme monthly gains sometimes precede corrections, so treat the ranking as a research starting point rather than a buy list.

Evaluate Your Positions

Researching one of this month's top movers? Use our Stock Return Calculator to review historical performance, or the Position Size Calculator to model position sizing and risk before making your own decision.