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Top Stock Gainers December 2022 - Monthly Performance Ranked

The top US-listed stocks of December 2022 by monthly gain, on split-adjusted closes. Ranks 3,849 companies above $100M on NYSE, Nasdaq and NYSE American.

Looking for intraday moves instead? Today's stock movers ranks the current session's alert board, so it measures against whichever session is running rather than covering a fixed window.

2022
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec

December 2022 ranking, complete through December 30, 2022

The same month on news: the biggest gains on news in December 2022 and the biggest drops, each ranked by the move on the day its story landed.

45 stocks are withheld from this ranking because their price history is under review.

The gain covers the period; price, market cap, sector and country show each company as it is today.

Swipe or scroll the table sideways for more columns.

Rank
Symbol
Company Name
Dec Gain
Market Cap (today)
Price (today)
Country
Sector
1
SMMT
Summit Therapeutics Inc.
+524.91%
$12.07B
$15.13
United States
Healthcare
2
PHVS
Pharvaris N.V.
+438.28%
$2.11B
$30.02
Switzerland
Healthcare
3
MDGL
Madrigal Pharmaceuticals, Inc.
+296.95%
$10.63B
$460.01
United States
Healthcare
4
ACIC
American Coastal Insurance Corporation
+231.25%
$497.75M
$10.53
United States
Financial Services
5
PRQR
ProQR Therapeutics N.V.
+203.28%
$207.44M
$1.47
Netherlands
Healthcare
6
VKTX
Viking Therapeutics, Inc
+127.60%
$3.24B
$25.47
United States
Healthcare
7
MSC
Studio City International Holdings Limited
+120.74%
$185.81M
$0.9648
Hong Kong
Consumer Cyclical
8
PROF
Profound Medical Corp.
+120.00%
$241.90M
$6.62
Canada
Healthcare
9
RIGL
Rigel Pharmaceuticals Inc. (New)
+119.27%
$874.59M
$46.82
United States
Healthcare
10
WDH
Waterdrop Inc.
+105.56%
$370.08M
$1.03
China
Financial Services
11
CABA
Cabaletta Bio, Inc.
+97.65%
$274.66M
$1.62
United States
Healthcare
12
AKBA
Akebia Therapeutics, Inc.
+97.54%
$194.53M
$0.7020
United States
Healthcare
13
IMMX
Immix Biopharma, Inc.
+97.43%
$705.50M
$8.51
United States
Healthcare
14
SLNO
Soleno Therapeutics, Inc.
+96.04%
$2.76B
$53.01
United States
Healthcare
15
VRNA
Verona Pharma plc
+90.59%
$9.04B
$106.40
United Kingdom
Healthcare
16
GOTU
Gaotu Techedu Inc.
+87.30%
$627.60M
$2.67
China
Consumer Defensive
17
IQ
iQIYI, Inc.
+82.13%
$918.03M
$0.9513
China
Communication Services
18
EH
EHang Holdings Limited
+80.25%
$286.70M
$3.78
China
Industrials
19
MAMA
Mama's Creations, Inc.
+79.50%
$611.97M
$12.98
United States
Consumer Defensive
20
TUYA
Tuya Inc.
+73.64%
$1.04B
$1.69
China
Technology
21
KRRO
Korro Bio, Inc.
+71.88%
$130.76M
$8.88
United States
Healthcare
22
CELC
Celcuity Inc.
+71.69%
$2.93B
$59.90
United States
Healthcare
23
MOMO
Hello Group Inc.
+64.17%
$676.52M
$4.71
China
Communication Services
24
IPHA
Innate Pharma S.A.
+62.88%
$159.73M
$1.43
France
Healthcare
25
ARDX
Ardelyx, Inc.
+62.86%
$823.62M
$3.19
United States
Healthcare
26
ALVO
Alvotech
+62.60%
$1.84B
$5.17
Luxembourg
Healthcare
27
WVE
Wave Life Sciences Ltd.
+60.92%
$608.88M
$3.09
United States
Healthcare
28
SY
So-Young International Inc.
+60.55%
$246.50M
$2.45
China
Healthcare
29
ACLX
Arcellx, Inc.
+57.26%
$6.73B
$115.07
United States
Healthcare
30
TUSK
Mammoth Energy Services, Inc.
+55.58%
$130.43M
$2.71
United States
Industrials
31
RERE
ATRenew Inc.
+55.38%
$881.53M
$3.98
China
Consumer Cyclical
32
ETNB
89bio, Inc.
+54.12%
$1.28B
$8.65
United States
Healthcare
33
BDSX
Biodesix, Inc.
+53.33%
$253.12M
$23.99
United States
Healthcare
34
ALT
Altimmune, Inc.
+52.46%
$449.34M
$2.31
United States
Healthcare
35
PMTS
CPI Card Group Inc.
+49.40%
$293.39M
$25.31
United States
Financial Services
36
HUYA
HUYA Inc.
+47.94%
$520.67M
$2.28
China
Communication Services
37
TGTX
TG Therapeutics, Inc.
+47.51%
$8.32B
$54.37
United States
Healthcare
38
TERN
Terns Pharmaceuticals, Inc.
+46.05%
$6.12B
$52.95
United States
Healthcare
39
ORIC
Oric Pharmaceuticals, Inc.
+45.79%
$1.20B
$11.59
United States
Healthcare
40
ORMP
Oramed Pharmaceuticals Inc.
+44.24%
$172.21M
$4.14
United States
Healthcare
41
PLSE
Pulse Biosciences, Inc
+43.52%
$3.30B
$46.32
United States
Healthcare
42
ASRT
Assertio Holdings, Inc.
+43.33%
$151.86M
$23.50
United States
Healthcare
43
EOSE
Eos Energy Enterprises, Inc.
+42.31%
$705.29M
$1.95
United States
Industrials
44
SOUN
SoundHound AI, Inc.
+41.60%
$2.01B
$4.53
United States
Technology
45
KINS
Kingstone Companies, Inc.
+40.64%
$266.94M
$18.44
United States
Financial Services
46
VOR
Vor Biopharma Inc.
+40.00%
$1.11B
$18.75
United States
Healthcare
47
PTGX
Protagonist Therapeutics, Inc
+39.87%
$8.82B
$136.28
United States
Healthcare
48
BILI
Bilibili Inc.
+39.19%
$5.88B
$14.27
China
Communication Services
49
GDS
GDS Holdings Limited
+38.67%
$5.18B
$25.86
China
Technology
50
XYF
X Financial
+38.53%
$179.13M
$4.85
China
Financial Services
51
SGU
Star Group, L.P. Common Units
+38.19%
$423.92M
$12.92
United States
Energy
52
ROIV
Roivant Sciences Ltd.
+37.76%
$24.28B
$33.62
United Kingdom
Healthcare
53
NINE
Nine Energy Service, Inc.
+37.59%
$111.46M
$7.99
United States
Energy
54
BLZE
Backblaze, Inc.
+37.28%
$601.98M
$9.72
United States
Technology
55
EVER
EverQuote, Inc.
+36.48%
$726.29M
$20.61
United States
Communication Services
56
REPL
Replimune Group, Inc.
+36.14%
$1.07B
$11.39
United States
Healthcare
57
NIU
Niu Technologies
+35.49%
$148.24M
$1.89
China
Consumer Cyclical
58
ATXS
Astria Therapeutics, Inc.
+35.36%
$718.13M
$12.58
United States
Healthcare
59
UAMY
United States Antimony Corporation
+35.17%
$417.58M
$2.79
United States
Basic Materials
60
PALI
Palisade Bio, Inc.
+35.06%
$257.92M
$1.48
United States
Healthcare
61
PDSB
PDS Biotechnology Corporation
+34.97%
$102.19M
$1.41
United States
Healthcare
62
POWL
Powell Industries Inc
+33.97%
$6.18B
$169.53
United States
Industrials
63
BWAY
Brainsway Ltd.
+33.51%
$463.31M
$11.51
Israel
Healthcare
64
API
Agora, Inc.
+32.99%
$365.26M
$4.32
United States
Technology
65
DRS
Leonardo DRS, Inc.
+32.57%
$9.33B
$34.94
United States
Industrials
66
MFH
Mercurity Fintech Holding Inc.
+32.41%
$510.48M
$7.39
United States
Technology
67
CPS
Cooper-Standard Automotive Inc.
+31.88%
$367.47M
$20.68
United States
Consumer Cyclical
68
DMAC
DiaMedica Therapeutics Inc.
+31.68%
$413.07M
$7.66
United States
Healthcare
69
SPRY
ARS Pharmaceuticals, Inc.
+31.64%
$390.83M
$3.93
United States
Healthcare
70
KC
Kingsoft Cloud Holdings Limited
+31.62%
$2.62B
$8.76
China
Technology
71
MLCO
Melco Resorts & Entertainment Limited
+31.43%
$1.60B
$4.20
Hong Kong
Consumer Cyclical
72
GBTG
Global Business Travel Group, Inc.
+31.07%
$4.96B
$9.50
United States
Consumer Cyclical
73
TCMD
Tactile Systems Technology, Inc.
+30.60%
$507.64M
$22.41
United States
Healthcare
74
LRMR
Larimar Therapeutics, Inc.
+30.28%
$217.12M
$2.09
United States
Healthcare
75
PPTA
Perpetua Resources Corp.
+29.78%
$2.17B
$17.38
United States
Basic Materials
76
TAL
TAL Education Group
+28.88%
$6.94B
$12.51
China
Consumer Defensive
77
CYH
Community Health Systems, Inc.
+28.19%
$420.21M
$2.98
United States
Healthcare
78
QFIN
Qfin Holdings, Inc.
+28.05%
$691.81M
$5.69
China
Financial Services
79
IMVT
Immunovant, Inc.
+27.97%
$5.76B
$27.90
United States
Healthcare
80
RZLT
Rezolute, Inc.
+27.78%
$409.14M
$4.23
United States
Healthcare
81
ZH
Zhihu Inc.
+27.45%
$282.51M
$3.37
China
Communication Services
82
ARWR
Arrowhead Research Corporation
+26.67%
$8.25B
$58.37
United States
Healthcare
83
KALV
KalVista Pharmaceuticals, Inc.
+26.59%
$1.44B
$27.00
United States
Healthcare
84
SMWB
Similarweb Ltd.
+26.57%
$732.46M
$8.30
Israel
Technology
85
APYX
Apyx Medical Corporation
+26.49%
$108.26M
$2.57
United States
Healthcare
86
WB
Weibo Corporation
+26.20%
$1.60B
$6.51
China
Communication Services
87
MG
Mistras Group Inc.
+26.09%
$659.19M
$20.69
United States
Industrials
88
STOK
Stoke Therapeutics, Inc.
+25.92%
$1.50B
$23.26
United States
Healthcare
89
DLO
DLocal Limited
+25.67%
$4.32B
$14.69
Uruguay
Technology
90
IOT
Samsara Inc.
+25.56%
$23.89B
$40.80
United States
Technology
91
OPOF
Old Point Financial Corp
+25.46%
$214.80M
$42.10
United States
Financial Services
92
CTLP
Cantaloupe, Inc.
+25.36%
$825.82M
$11.20
United States
Technology
93
MDWD
MediWound Ltd.
+25.14%
$153.76M
$11.91
Israel
Healthcare
94
DCTH
Delcath Systems Inc
+25.00%
$510.77M
$14.72
United States
Healthcare
95
PLX
Protalix BioTherapeutics, Inc.
+24.55%
$210.29M
$2.61
United States
Healthcare
96
ADAG
Adagene Inc.
+24.41%
$153.76M
$2.29
China
Healthcare
97
COFS
CHOICEONE FINANCIAL
+23.25%
$480.82M
$32.15
United States
Financial Services
98
NAMS
NewAmsterdam Pharma Company N.V.
+23.16%
$2.34B
$20.01
Netherlands
Healthcare
99
WLFC
Willis Lease Finance Corp
+22.96%
$801.15M
$37.89
United States
Industrials
100
EDU
New Oriental Education and Technology Group, Inc.
+22.78%
$8.93B
$57.58
China
Consumer Defensive
S&P 500 fund (SPY) -6.12%
Finished higher 22% of 3,849
Median move -5.4%
Leading sector Utilities -1.2% median
Lagging sector Technology -7.3% median

Over December 2022, 22% of the 3,849 ranked companies finished higher and the median move was -5.4%; Utilities led on median (-1.2%) and Technology lagged (-7.3%). The S&P 500 fund (SPY) moved -6.12% between its Dec 1, 2022 and Dec 30, 2022 closes. Each ranked company's gain runs from its own first close inside the period, so a company listed later in the period is measured over a shorter window.

Top gain on this page +524.91% SMMT
Rows on this page 100 ranks 1–100
Page 1 of 39
Period December 2022 closed

Best performing large-cap stocks in December 2022

SMMT Summit Therapeutics Inc. +524.91% $12.07B
MDGL Madrigal Pharmaceuticals, Inc. +296.95% $10.63B
ROIV Roivant Sciences Ltd. +37.76% $24.28B
IOT Samsara Inc. +25.56% $23.89B
MUFG Mitsubishi UFJ Financial Gr... +21.72% $246.28B

December 2022 Stock Market Momentum

This page answers a current-month trend question with data: which US-listed stocks have shown the strongest price gains so far in December 2022. The ranking is based on observed market performance, not analyst ratings, price targets, or investment recommendations.

Use the list to research momentum, market breadth, sector strength, and catalysts behind large moves. Before acting on any stock, review the company's news, SEC filings, liquidity, volatility, and your own risk constraints.

Looking for a specific Symbol?
#1 SMMT leads with +525% December 2022

Among the 3,849 NYSE, Nasdaq and NYSE American stocks currently eligible for this ranking, SMMT (Summit Therapeutics Inc.) has the highest gain in December 2022 with +525%. Following are PHVS (+438%) and MDGL (+297%). Top performing sectors: Healthcare (+75% avg, 7 in top 10), Financial Services (+68% avg, 2 in top 10), Consumer Defensive (+55% avg).

MARKET LEADERS
52-WEEK LEADER
MGRT +1886%
Mega Fortune Company L..
2022 YTD LEADER
NINE +1131%
Nine Energy Service, I..
DEC 2022 LEADER
SMMT +525%
Summit Therapeutics Inc.
52-Week Top 5 Full List →
1 MGRT +1885.7% 2 AXTI +1184.0% 3 SNDK +895.2% 4 MRNA +809.3% 5 ANL +637.2%
2022 YTD Top 5 Full List →
1 NINE +1131.4% 2 META +689.1% 3 INDV +557.1% 4 KLXE +394.6% 5 TUSK +348.2%
December 2022 Top 5 Full List →
1 SMMT +524.9% 2 PHVS +438.3% 3 MDGL +296.9% 4 ACIC +231.3% 5 PRQR +203.3%
Quick Access: 52-Week 2022 YTD Dec 2022 Market Cap Dividends

This ranking shows the top performing stocks and biggest stock gainers during December 2022, calculated from the first to the last trading day of the month. It shows which stocks are going up this month, with split-adjusted data used for consistent performance calculations.

Monthly performance rankings can reveal price strength, sustained momentum, sector rotation, and event-driven moves that are not visible in one-day movers lists. The table is informational only and does not recommend any stock to buy, sell, or hold.

Gains are computed on split-adjusted closes, so a split inside the month does not read as a move. This ranking is informational and is not investment advice.
What this ranking covers
Universe
US-listed companies on NYSE, Nasdaq and NYSE American.
Floors
Market cap of at least $100 million, and one close inside the month to measure from.
Exclusions
Stocks whose price history is under review are withheld, and their count is stated above.
Measured on
Split-adjusted closes, from the first close inside the month to the last one in it.
Refreshed
Rebuilt once the session behind those closes has settled. The date above the table names that session, not the moment the table was written.

Frequently Asked Questions

Q Which stock has gained the most in December 2022?
A

SMMT (Summit Therapeutics Inc.) has the highest monthly gain in this ranking for December 2022, with a gain of 525%. Top performers this month include SMMT, PHVS, MDGL.

Q What stocks gained the most in December 2022?
A

The biggest gainers in December 2022 were: SMMT (+525%), PHVS (+438%), MDGL (+297%), ACIC (+231%), PRQR (+203%). These monthly rankings show which stocks had the strongest short-term momentum.

Q Does this page recommend the best stocks to buy now?
A

No. This page is an informational ranking of stocks that have already gone up during December 2022. It does not make buy, sell, or hold recommendations and should be used as a research starting point, not financial advice.

Q How can this ranking help explain current stock market trends?
A

The ranking shows where price strength is concentrated during December 2022. Comparing the top gainers by sector, market cap, and recent catalysts can help identify momentum themes and market rotation without implying that any listed stock is a recommendation.

Q Which companies does this ranking include?
A

3,849 companies with a market capitalization above $100 million traded on NYSE, Nasdaq and NYSE American, each with at least one trading day inside December 2022. One close inside the month is enough to qualify, so a company that listed during the month is ranked on the part of it that it traded.

Q Which sectors performed best in December 2022?
A

The five highest-gaining companies in December 2022 sit in Healthcare, Financial Services, with the leader SMMT in Healthcare. That describes the top of this list, not a sector ranking; the market-context strip above the table reports the median move of each sector's ranked companies.

Q How is monthly stock performance calculated?
A

Monthly stock performance is calculated by comparing the closing price on the last trading day of the month to the closing price on its first trading day, both split-adjusted. A company whose trading history begins inside the month is measured from its first close.

Q Where can I find today's top stock gainers and most active stocks?
A

This page ranks stocks by their full-month performance in December 2022. For today's top stock gainers, real-time stock movers, and the most active stocks right now, visit our Momentum Scanner, which tracks live intraday activity across US-listed symbols.

Understanding Monthly Stock Performance

Monthly performance rankings reveal short-term momentum patterns and help identify stocks experiencing rapid price movements:

  • Momentum Research: Stocks showing strong monthly performance can help identify where market attention and price strength are concentrated.
  • Sector Rotation: Monthly rankings can reveal which sectors are gaining favor with investors and where market leadership is shifting.
  • Event-Driven Moves: Earnings releases, product launches, and regulatory approvals often create significant monthly price movements.

Using Monthly Data Effectively

  • Combine Timeframes: Compare monthly gainers with 52-week and YTD performance to identify stocks with both short and long-term momentum.
  • Research the Catalyst: Investigate why top monthly performers moved significantly. The reason for the move matters as much as the percentage gain.
  • Watch for Reversals: Extreme monthly gains sometimes precede corrections, so treat the ranking as a research starting point rather than a buy list.

Evaluate Your Positions

Researching one of this month's top movers? Use our Stock Return Calculator to review historical performance, or the Position Size Calculator to model position sizing and risk before making your own decision.