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MARKET LEADERS
52-WEEK LEADER
BW +3367%
Babcock & Wilcox Enter..
2022 YTD LEADER
BEAG +9999%
Bold Eagle Acquisition..
SEP 2022 LEADER
KNW +3111%
Know Labs, Inc.
📈 52-Week Top 5 Full List →
1 BW +3367.2% 2 BE +1101.5% 3 PL +939.3% 4 AMPX +713.4% 5 CIEN +683.4%
📅 2022 YTD Top 5 Full List →
1 BEAG +9999.0% 2 SNWV +9999.0% 3 META +4326.4% 4 CLS +3559.3% 5 TSSI +3384.5%
🗓 September 2022 Top 5 Full List →
1 KNW +3110.5% 2 GOAI +252.5% 3 AKRO +169.2% 4 SPRO +162.3% 5 PRTA +120.2%
Quick Access: 52-Week 2022 YTD Sep 2022 Market Cap Dividends
#1 KNW leads with +3,111% September 2022

KNW (Know Labs, Inc.) is the best performing stock in September 2022. Following are GOAI (+253%) and AKRO (+169%). Top performing sectors: Technology (+230% avg, 2 in top 10), Healthcare (+39% avg, 7 in top 10), Industrials (+38% avg, 1 in top 10).

Top Stock Gainers September 2022 - Monthly Performance Ranked

Track the top performing stocks of September 2022 ranked by monthly price gain. See which stock gainers delivered the highest gains this month, with market caps over $100 million on Nasdaq and NYSE.
2022
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec

This ranking shows the top performing stocks and biggest stock gainers during September 2022, calculated from the first to the last trading day of the month. It shows which stocks are going up this month, with split-adjusted data used for consistent performance calculations.

Monthly performance rankings can reveal price strength, sustained momentum, sector rotation, and event-driven moves that are not visible in one-day movers lists. The table is informational only and does not recommend any stock to buy, sell, or hold.

September 2022 Stock Market Momentum

This page answers a current-month trend question with data: which NYSE and NASDAQ stocks have shown the strongest price gains so far in September 2022. The ranking is based on observed market performance, not analyst ratings, price targets, or investment recommendations.

Use the list to research momentum, market breadth, sector strength, and catalysts behind large moves. Before acting on any stock, review the company's news, SEC filings, liquidity, volatility, and your own risk constraints.

Looking for a specific Symbol?

Data as of April 27, 2026 at 12:38 PM EDT

Rank
Symbol
Company Name
Sep Gain
Market Cap
Price
Country
Sector
1
KNW
Know Labs, Inc.
3110.53%
822.26 M
$ 2.14
United States
Technology
2
GOAI
Eva Live, Inc.
252.51%
130.43 M
$ 3.57
United States
Technology
3
AKRO
Akero Therapeutics, Inc.
169.17%
3.59 B
$ 44.93
United States
Healthcare
4
SPRO
Spero Therapeutics, Inc.
162.33%
158.62 M
$ 2.74
United States
Healthcare
5
PRTA
Prothena Corporation plc
120.23%
578.70 M
$ 10.75
Ireland
Healthcare
6
IMRX
Immuneering Corporation
106.04%
390.77 M
$ 6.04
United States
Healthcare
7
ELVN
Enliven Therapeutics, Inc.
105.41%
2.65 B
$ 44.25
United States
Healthcare
8
EVTL
Vertical Aerospace Ltd.
79.31%
301.77 M
$ 2.37
United Kingdom
Industrials
9
PLSE
Pulse Biosciences, Inc.
75.57%
1.57 B
$ 23.02
United States
Healthcare
10
SAVA
Cassava Sciences Inc
65.04%
114.97 M
$ 2.38
United States
Healthcare
11
ABOS
Acumen Pharmaceuticals, Inc.
64.7%
185.62 M
$ 2.57
United States
Healthcare
12
XFOR
X4 Pharmaceuticals, Inc.
64.42%
373.68 M
$ 4.11
United States
Healthcare
13
INNV
InnovAge Holding Corp.
62.43%
1.08 B
$ 7.95
United States
Healthcare
14
VTYX
Ventyx Biosciences Inc
58.75%
1.00 B
$ 14
United States
Healthcare
15
TERN
Terns Pharmaceuticals, Inc.
53.39%
6.10 B
$ 52.89
United States
Healthcare
16
IDYA
IDEAYA Biosciences, Inc.
52.24%
2.70 B
$ 30.73
United States
Healthcare
17
EVI
EVI Industries, Inc.
47.24%
287.40 M
$ 19.94
United States
Industrials
18
CRCT
Cricut, Inc.
46.75%
942.43 M
$ 4.45
United States
Technology
19
DWSN
Dawson Geophysical Company
44.55%
100.61 M
$ 3.24
United States
Energy
20
EVEX
Eve Holding, Inc.
44.15%
964.80 M
$ 2.77
United States
Industrials
21
NGD
New Gold Inc.
39.75%
7.21 B
$ 9.08
Canada
Basic Materials
22
AURA
Aura Biosciences, Inc.
36.34%
466.73 M
$ 7.27
United States
Healthcare
23
HROW
Harrow, Inc.
35.92%
1.48 B
$ 39.7
United States
Healthcare
24
BIIB
Biogen Inc.
33.64%
27.06 B
$ 184.38
United States
Healthcare
25
INTA
Intapp, Inc.
32.41%
1.79 B
$ 22.25
United States
Technology
26
CDE
Coeur Mining, Inc.
30.53%
19.99 B
$ 19.31
United States
Basic Materials
27
MSC
Studio City International H...
30.36%
519.99 M
$ 2.7
Hong Kong
Consumer Cyclical
28
CVRX
CVRx, Inc.
29.4%
203.13 M
$ 7.72
United States
Healthcare
29
ETNB
89bio, Inc.
29.24%
1.28 B
$ 8.65
United States
Healthcare
30
QBTS
D-Wave Quantum Inc.
29.23%
6.85 B
$ 18.49
United States
Technology
31
HLVX
HilleVax, Inc.
28.98%
104.76 M
$ 2.09
United States
Healthcare
32
TYRA
Tyra Biosciences, Inc.
28.89%
2.24 B
$ 37.59
United States
Healthcare
33
NEOV
NeoVolta Inc.
28.32%
118.74 M
$ 2.78
United States
Industrials
34
BVN
Compañía de Minas Buenavent...
28.19%
8.32 B
$ 32.76
Peru
Basic Materials
35
SGML
Sigma Lithium Corporation
27.71%
2.19 B
$ 19.69
Canada
Basic Materials
36
AXGN
Axogen, Inc.
27.08%
2.04 B
$ 39.25
United States
Healthcare
37
PHAT
Phathom Pharmaceuticals, Inc.
26.77%
929.33 M
$ 11.7
United States
Healthcare
38
CTGO
Contango Silver & Gold Inc.
26.75%
696.79 M
$ 22.84
United States
Basic Materials
39
PRO
PROS Holdings, Inc.
26.15%
744.69 M
$ 15.48
United States
Technology
40
WIX
Wix.com Ltd.
25.73%
4.41 B
$ 75.67
Israel
Technology
41
COE
51Talk Online Education Group
25.49%
154.63 M
$ 25.74
Singapore
Consumer Defensive
42
CTKB
Cytek Biosciences, Inc.
25.17%
565.62 M
$ 4.4
United States
Healthcare
43
AAOI
Applied Optoelectronics, Inc.
24.77%
12.60 B
$ 162.17
United States
Technology
44
AREN
The Arena Group Holdings, Inc.
24.76%
104.73 M
$ 2.2
United States
Communication Services
45
ASAN
Asana, Inc.
24.75%
1.52 B
$ 6.39
United States
Technology
46
LRMR
Larimar Therapeutics, Inc.
24.03%
471.63 M
$ 4.54
United States
Healthcare
47
MLCO
Melco Resorts & Entertainme...
23.46%
2.29 B
$ 5.63
Hong Kong
Consumer Cyclical
48
RLMD
Relmada Therapeutics, Inc.
23.44%
756.26 M
$ 7.21
United States
Healthcare
49
WVE
Wave Life Sciences Ltd.
22.79%
1.35 B
$ 7.18
Singapore
Healthcare
50
MRVI
Maravai LifeSciences Holdin...
21.98%
1.31 B
$ 3.55
United States
Healthcare
51
JANX
Janux Therapeutics, Inc.
21.87%
913.08 M
$ 15.01
United States
Healthcare
52
INSW
International Seaways, Inc.
21.6%
3.93 B
$ 79.55
United States
Energy
53
ERO
Ero Copper Corp.
21.55%
2.85 B
$ 27.31
Canada
Basic Materials
54
ARDX
Ardelyx, Inc.
21.43%
1.46 B
$ 5.95
United States
Healthcare
55
TRDA
Entrada Therapeutics, Inc.
21.23%
483.53 M
$ 12.63
United States
Healthcare
56
KGC
Kinross Gold Corporation
20.9%
39.42 B
$ 32.79
Canada
Basic Materials
57
CCLD
CareCloud, Inc.
20.81%
129.60 M
$ 3.05
United States
Healthcare
58
PLG
Platinum Group Metals Ltd.
20.74%
227.02 M
$ 1.79
Canada
Basic Materials
59
SMID
Smith-Midland Corporation
20.55%
181.38 M
$ 34.18
United States
Basic Materials
60
COEP
Coeptis Therapeutics Holdin...
20.51%
102.06 M
$ 16.4
United States
Healthcare
61
DYN
Dyne Therapeutics, Inc.
20.15%
3.02 B
$ 18.26
United States
Healthcare
62
IBRX
ImmunityBio, Inc.
20.05%
7.68 B
$ 7.44
United States
Healthcare
63
WK
Workiva Inc.
19.84%
3.02 B
$ 53.15
United States
Technology
64
TC
Token Cat Limited
19.73%
217.99 M
$ 9.916
China
Communication Services
65
QTRX
Quanterix Corporation
19.65%
153.96 M
$ 3.28
United States
Healthcare
66
AMLX
Amylyx Pharmaceuticals, Inc.
19.58%
1.89 B
$ 17.04
United States
Healthcare
67
ANTX
AN2 Therapeutics, Inc.
19.37%
156.22 M
$ 4.34
United States
Healthcare
68
HLIT
Harmonic Inc.
19.14%
1.19 B
$ 10.56
United States
Technology
69
TNK
Teekay Tankers Ltd.
18.81%
2.63 B
$ 75.94
Bermuda
Energy
70
RZLT
Rezolute, Inc.
18.61%
296.66 M
$ 3.1
United States
Healthcare
71
BEBE
TGE Value Creative Solution...
18.43%
198.60 M
$ 9.93
France
Financial Services
72
WFRD
Weatherford International plc
18.15%
7.81 B
$ 108.54
United States
Energy
73
OPOF
Old Point Financial Corpora...
18.1%
214.80 M
$ 42.1
United States
Financial Services
74
NRC
NRC Health
17.93%
391.92 M
$ 17.23
United States
Healthcare
75
MOLN
Molecular Partners AG
17.16%
166.85 M
$ 4.4599
Switzerland
Healthcare
76
FRPT
Freshpet, Inc.
16.79%
3.25 B
$ 66.15
United States
Consumer Defensive
77
NCNO
nCino, Inc.
16.18%
2.03 B
$ 17.68
United States
Technology
78
ASND
Ascendis Pharma A/S
15.91%
14.16 B
$ 229.27
Denmark
Healthcare
79
FOA
Finance of America Companie...
15.63%
183.52 M
$ 21.46
United States
Financial Services
80
THTX
Theratechnologies Inc.
15.61%
150.81 M
$ 3.28
Canada
Healthcare
81
CINT
CI&T Inc.
15.5%
546.08 M
$ 4.23
Brazil
Technology
82
IFRX
InflaRx N.V.
15.28%
106.99 M
$ 1.48
Germany
Healthcare
83
CCRN
Cross Country Healthcare, Inc.
15.14%
323.92 M
$ 10.06
United States
Healthcare
84
FSM
Fortuna Mining Corp.
15.07%
3.13 B
$ 10.27
Canada
Basic Materials
85
ATEC
Alphatec Holdings, Inc.
15%
1.65 B
$ 10.9
United States
Healthcare
86
REGN
Regeneron Pharmaceuticals, ...
14.69%
79.46 B
$ 751.57
United States
Healthcare
87
NG
NovaGold Resources Inc.
14.67%
3.79 B
$ 8.63
Canada
Basic Materials
88
ARL
American Realty Investors, ...
14.61%
234.20 M
$ 14.5
United States
Real Estate
89
NUVL
Nuvalent, Inc.
14.49%
8.22 B
$ 104.5
United States
Healthcare
90
ANIX
Anixa Biosciences, Inc.
14.42%
102.26 M
$ 3.05
United States
Healthcare
91
XMTR
Xometry, Inc.
14.2%
2.47 B
$ 47.71
United States
Industrials
92
PEN
Penumbra, Inc.
14.04%
12.95 B
$ 329.89
United States
Healthcare
93
EGO
Eldorado Gold Corporation
13.99%
8.45 B
$ 32.07
Canada
Basic Materials
94
DNA
Ginkgo Bioworks Holdings, Inc.
13.87%
487.34 M
$ 7.87
United States
Healthcare
95
ZVRA
Zevra Therapeutics, Inc.
13.66%
595.88 M
$ 10.08
United States
Healthcare
96
ISSC
Innovative Aerosystems, Inc.
13.55%
353.79 M
$ 19.9
United States
Industrials
97
CWAN
Clearwater Analytics Holdin...
13.45%
7.19 B
$ 24.15
United States
Technology
98
PRTH
Priority Technology Holding...
13.32%
438.58 M
$ 5.33
United States
Technology
99
SSRM
SSR Mining Inc.
12.98%
6.26 B
$ 30.55
United States
Basic Materials
100
ZS
Zscaler, Inc.
12.91%
21.79 B
$ 135.5
United States
Technology
For the most accurate results, consider cross-referencing our data with other sources.

Frequently Asked Questions

Q Which stock has gained the most in September 2022?
A

KNW (Know Labs, Inc.) has the highest monthly gain in this ranking for September 2022, with a gain of 3,111%. Top performers this month include KNW, GOAI, AKRO.

Q What stocks gained the most in September 2022?
A

The biggest gainers in September 2022 were: KNW (+3,111%), GOAI (+253%), AKRO (+169%), SPRO (+162%), PRTA (+120%). These monthly rankings show which stocks had the strongest short-term momentum.

Q Does this page recommend the best stocks to buy now?
A

No. This page is an informational ranking of stocks that have already gone up during September 2022. It does not make buy, sell, or hold recommendations and should be used as a research starting point, not financial advice.

Q How can this ranking help explain current stock market trends?
A

The ranking shows where price strength is concentrated during September 2022. Comparing the top gainers by sector, market cap, and recent catalysts can help identify momentum themes and market rotation without implying that any listed stock is a recommendation.

Q Which sectors performed best in September 2022?
A

The top performing sectors in September 2022 included Technology, Healthcare, based on the stocks with highest monthly gains. KNW led the Technology sector.

Q How is monthly stock performance calculated?
A

Monthly stock performance is calculated by comparing the closing price on the last trading day of the month to the opening price on the first trading day. Split-adjusted prices ensure accuracy.

Q Where can I find today's top stock gainers and most active stocks?
A

This page ranks stocks by their full-month performance in September 2022. For today's top stock gainers, real-time stock movers, and the most active stocks right now, visit our Momentum Scanner which tracks live intraday market activity across NYSE and NASDAQ.

Understanding Monthly Stock Performance

Monthly performance rankings reveal short-term momentum patterns and help identify stocks experiencing rapid price movements:

  • Momentum Research: Stocks showing strong monthly performance can help identify where market attention and price strength are concentrated.
  • Sector Rotation: Monthly rankings can reveal which sectors are gaining favor with investors and where market leadership is shifting.
  • Event-Driven Moves: Earnings releases, product launches, and regulatory approvals often create significant monthly price movements.

Using Monthly Data Effectively

  • Combine Timeframes: Compare monthly gainers with 52-week and YTD performance to identify stocks with both short and long-term momentum.
  • Research the Catalyst: Investigate why top monthly performers moved significantly. The reason for the move matters as much as the percentage gain.
  • Watch for Reversals: Extreme monthly gains sometimes precede corrections, so treat the ranking as a research starting point rather than a buy list.

Evaluate Your Positions

Researching one of this month's top movers? Use our Stock Return Calculator to review historical performance, or the Position Size Calculator to model position sizing and risk before making your own decision.