STOCK TITAN

Top Stock Gainers September 2022 - Monthly Performance Ranked

The top US-listed stocks of September 2022 by monthly gain, on split-adjusted closes. Ranks 3,429 companies above $100M on NYSE, Nasdaq and NYSE American.
2022

September 2022 ranking, complete through September 30, 2022

29 stocks are withheld from this ranking because their price history is under review.

The gain covers the period; price, market cap, sector and country show each company as it is today.

Swipe or scroll the table sideways for more columns.

Rank
Symbol
Company Name
Sep Gain
Market Cap (today)
Price (today)
Country
Sector
1
+169.17%
$3.59B
$44.93
United States
Healthcare
2
+120.23%
$485.13M
$9.45
Ireland
Healthcare
3
+106.04%
$342.90M
$5.30
United States
Healthcare
4
+105.41%
$4.38B
$59.82
United States
Healthcare
5
+79.31%
$131.75M
$0.7672
United Kingdom
Industrials
6
+75.57%
$3.60B
$50.42
United States
Healthcare
7
+65.04%
$114.97M
$2.38
United States
Healthcare
8
+64.70%
$228.52M
$3.16
United States
Healthcare
9
+64.42%
$400.55M
$4.04
United States
Healthcare
10
+62.43%
$1.49B
$10.96
United States
Healthcare
11
+58.75%
$1.00B
$14.00
United States
Healthcare
12
+53.39%
$6.12B
$52.95
United States
Healthcare
13
+52.24%
$3.83B
$39.67
United States
Healthcare
14
+47.24%
$194.84M
$15.14
United States
Industrials
15
+46.75%
$1.17B
$5.59
United States
Technology
16
+45.35%
$103.77M
$5.58
United States
Energy
17
+44.55%
$105.90M
$3.41
United States
Energy
18
+44.15%
$916.52M
$2.63
United States
Industrials
19
+39.75%
$7.21B
$9.08
Canada
Basic Materials
20
+36.34%
$808.90M
$7.80
United States
Healthcare
21
+35.92%
$1.54B
$40.95
United States
Healthcare
22
+35.16%
$1.75B
$14.13
Singapore
Financial Services
23
+33.64%
$32.03B
$216.78
United States
Healthcare
24
+32.41%
$3.16B
$41.35
United States
Technology
25
+30.53%
$21.56B
$20.97
United States
Basic Materials
26
+30.36%
$357.25M
$1.85
Hong Kong
Consumer Cyclical
27
+29.24%
$1.28B
$8.65
United States
Healthcare
28
+29.23%
$7.59B
$20.39
United States
Technology
29
+28.98%
$104.76M
$2.09
United States
Healthcare
30
+28.89%
$1.55B
$26.05
United States
Healthcare
31
+28.32%
$196.60M
$3.34
United States
Industrials
32
+27.71%
$1.35B
$11.97
Canada
Basic Materials
33
+27.08%
$2.71B
$50.40
United States
Healthcare
34
+26.77%
$717.59M
$8.87
United States
Healthcare
35
+26.75%
$669.15M
$20.01
United States
Basic Materials
36
+26.15%
$744.69M
$15.48
United States
Technology
37
+25.73%
$3.43B
$82.07
Israel
Technology
38
+25.17%
$625.22M
$4.81
United States
Healthcare
39
+24.77%
$10.56B
$124.82
United States
Technology
40
+24.75%
$2.21B
$9.58
United States
Technology
41
+24.03%
$434.23M
$4.18
United States
Healthcare
42
+23.46%
$2.09B
$5.49
Hong Kong
Consumer Cyclical
43
+23.44%
$493.88M
$4.63
United States
Healthcare
44
+22.79%
$1.04B
$5.29
United States
Healthcare
45
+21.98%
$3.20B
$8.64
United States
Healthcare
46
+21.87%
$1.06B
$17.39
United States
Healthcare
47
+21.60%
$4.93B
$99.52
United States
Energy
48
+21.55%
$4.11B
$39.42
Canada
Basic Materials
49
+21.43%
$1.00B
$3.89
United States
Healthcare
50
+21.23%
$294.75M
$7.57
United States
Healthcare
51
+20.90%
$38.86B
$32.76
Canada
Basic Materials
52
+20.81%
$106.66M
$2.51
United States
Healthcare
53
+20.55%
$146.88M
$27.69
United States
Basic Materials
54
+20.15%
$4.87B
$26.10
United States
Healthcare
55
+20.05%
$8.26B
$7.79
United States
Healthcare
56
+19.84%
$4.07B
$74.83
United States
Technology
57
+19.65%
$141.41M
$2.99
United States
Healthcare
58
+19.58%
$4.31B
$38.66
United States
Healthcare
59
+19.37%
$219.25M
$5.81
United States
Healthcare
60
+19.27%
$142.42M
$1.38
United States
Healthcare
61
+19.14%
$1.36B
$12.47
United States
Technology
62
+18.81%
$3.16B
$91.02
Bermuda
Energy
63
+18.61%
$490.13M
$5.09
United States
Healthcare
64
+18.43%
$199.80M
$9.99
France
Financial Services
65
+18.15%
$6.49B
$90.51
United States
Energy
66
+18.10%
$214.80M
$42.10
United States
Financial Services
67
+17.93%
$490.83M
$22.19
United States
Healthcare
68
+17.16%
$165.05M
$4.40
Switzerland
Healthcare
69
+16.79%
$3.55B
$73.97
United States
Consumer Defensive
70
+16.18%
$2.26B
$20.62
United States
Technology
71
+15.91%
$16.61B
$253.29
Denmark
Healthcare
72
+15.63%
$184.82M
$20.05
United States
Financial Services
73
+15.61%
$150.81M
$3.28
Canada
Healthcare
74
+15.50%
$497.88M
$3.89
Brazil
Technology
75
+15.28%
$309.47M
$2.10
Germany
Healthcare
76
+15.14%
$428.06M
$13.25
United States
Healthcare
77
+15.07%
$3.57B
$12.07
Canada
Basic Materials
78
+15.00%
$1.46B
$9.48
United States
Healthcare
79
+14.69%
$85.87B
$834.04
United States
Healthcare
80
+14.67%
$3.83B
$8.72
Canada
Basic Materials
81
+14.49%
$9.81B
$123.96
United States
Healthcare
82
+14.42%
$126.23M
$3.71
United States
Healthcare
83
+14.20%
$4.79B
$83.59
United States
Industrials
84
+14.04%
$12.81B
$325.18
United States
Healthcare
85
+13.99%
$11.92B
$45.72
Canada
Basic Materials
86
+13.87%
$498.32M
$7.40
United States
Healthcare
87
+13.66%
$704.89M
$11.87
United States
Healthcare
88
+13.55%
$443.54M
$24.78
United States
Industrials
89
+13.45%
$7.33B
$24.56
United States
Technology
90
+13.32%
$462.49M
$5.61
United States
Technology
91
+12.98%
$7.70B
$37.77
United States
Basic Materials
92
+12.91%
$29.39B
$181.75
United States
Technology
93
+12.63%
$276.20M
$84.94
United States
Financial Services
94
+12.48%
$489.51M
$36.56
United States
Technology
95
+12.41%
$302.21M
$5.63
United States
Healthcare
96
+12.32%
$1.11B
$45.15
United States
Financial Services
97
+11.98%
$166.74M
$1.30
United Kingdom
Consumer Defensive
98
+11.93%
$6.14B
$68.62
United States
Healthcare
99
+11.92%
$282.25M
$4.34
United States
Healthcare
100
+11.65%
$4.23B
$28.10
Argentina
Energy
Top gain on this page +169.17% AKRO
Rows on this page 100 ranks 1–100
Page 1 of 35
Period September 2022 closed

Best performing large-cap stocks in September 2022

BIIB Biogen Inc. +33.64% $32.03B
CDE Coeur Mining, Inc. +30.53% $21.56B
AAOI Applied Optoelectronics, Inc. +24.77% $10.56B
KGC Kinross Gold Corporation +20.90% $38.86B
ASND Ascendis Pharma A/S +15.91% $16.61B

September 2022 Stock Market Momentum

This page answers a current-month trend question with data: which US-listed stocks have shown the strongest price gains so far in September 2022. The ranking is based on observed market performance, not analyst ratings, price targets, or investment recommendations.

Use the list to research momentum, market breadth, sector strength, and catalysts behind large moves. Before acting on any stock, review the company's news, SEC filings, liquidity, volatility, and your own risk constraints.

Looking for a specific Symbol?
#1 AKRO leads with +169% September 2022

Among the 3,429 NYSE, Nasdaq and NYSE American stocks currently eligible for this ranking, AKRO (Akero Therapeutics) has the highest gain in September 2022 with +169%. Following are PRTA (+120%) and IMRX (+106%). Top performing sectors: Industrials (+38% avg, 1 in top 10), Healthcare (+35% avg, 9 in top 10), Energy (+27% avg).

MARKET LEADERS

This ranking shows the top performing stocks and biggest stock gainers during September 2022, calculated from the first to the last trading day of the month. It shows which stocks are going up this month, with split-adjusted data used for consistent performance calculations.

Monthly performance rankings can reveal price strength, sustained momentum, sector rotation, and event-driven moves that are not visible in one-day movers lists. The table is informational only and does not recommend any stock to buy, sell, or hold.

Gains are computed on split-adjusted closes, so a split inside the month does not read as a move. This ranking is informational and is not investment advice.

Frequently Asked Questions

Q Which stock has gained the most in September 2022?
A

AKRO (Akero Therapeutics) has the highest monthly gain in this ranking for September 2022, with a gain of 169%. Top performers this month include AKRO, PRTA, IMRX.

Q What stocks gained the most in September 2022?
A

The biggest gainers in September 2022 were: AKRO (+169%), PRTA (+120%), IMRX (+106%), ELVN (+105%), EVTL (+79%). These monthly rankings show which stocks had the strongest short-term momentum.

Q Does this page recommend the best stocks to buy now?
A

No. This page is an informational ranking of stocks that have already gone up during September 2022. It does not make buy, sell, or hold recommendations and should be used as a research starting point, not financial advice.

Q How can this ranking help explain current stock market trends?
A

The ranking shows where price strength is concentrated during September 2022. Comparing the top gainers by sector, market cap, and recent catalysts can help identify momentum themes and market rotation without implying that any listed stock is a recommendation.

Q Which companies does this ranking include?
A

3,429 companies with a market capitalization above $100 million traded on NYSE, Nasdaq and NYSE American, each with at least one trading day inside September 2022. One close inside the month is enough to qualify, so a company that listed during the month is ranked on the part of it that it traded.

Q Which sectors performed best in September 2022?
A

The top performing sectors in September 2022 included Healthcare, Industrials, based on the stocks with highest monthly gains. AKRO led the Healthcare sector.

Q How is monthly stock performance calculated?
A

Monthly stock performance is calculated by comparing the closing price on the last trading day of the month to the opening price on the first trading day. Split-adjusted prices ensure accuracy.

Q Where can I find today's top stock gainers and most active stocks?
A

This page ranks stocks by their full-month performance in September 2022. For today's top stock gainers, real-time stock movers, and the most active stocks right now, visit our Momentum Scanner, which tracks live intraday activity across US-listed symbols.

Understanding Monthly Stock Performance

Monthly performance rankings reveal short-term momentum patterns and help identify stocks experiencing rapid price movements:

  • Momentum Research: Stocks showing strong monthly performance can help identify where market attention and price strength are concentrated.
  • Sector Rotation: Monthly rankings can reveal which sectors are gaining favor with investors and where market leadership is shifting.
  • Event-Driven Moves: Earnings releases, product launches, and regulatory approvals often create significant monthly price movements.

Using Monthly Data Effectively

  • Combine Timeframes: Compare monthly gainers with 52-week and YTD performance to identify stocks with both short and long-term momentum.
  • Research the Catalyst: Investigate why top monthly performers moved significantly. The reason for the move matters as much as the percentage gain.
  • Watch for Reversals: Extreme monthly gains sometimes precede corrections, so treat the ranking as a research starting point rather than a buy list.

Evaluate Your Positions

Researching one of this month's top movers? Use our Stock Return Calculator to review historical performance, or the Position Size Calculator to model position sizing and risk before making your own decision.