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MARKET LEADERS
52-WEEK LEADER
MGRT +3778%
Mega Fortune Company L..
2022 YTD LEADER
NINE +1131%
Nine Energy Service, I..
DEC 2022 LEADER
SMMT +525%
Summit Therapeutics Inc.
📈 52-Week Top 5 Full List →
1 MGRT +3777.9% 2 SNDK +2426.2% 3 AXTI +1917.0% 4 ERAS +1071.6% 5 BW +898.6%
📅 2022 YTD Top 5 Full List →
1 NINE +1131.4% 2 META +689.1% 3 INDV +557.1% 4 TUSK +348.2% 5 RDUS +319.0%
🗓 December 2022 Top 5 Full List →
1 SMMT +524.9% 2 PHVS +438.3% 3 MDGL +296.9% 4 ACIC +231.3% 5 PRQR +203.3%
Quick Access: 52-Week 2022 YTD Dec 2022 Market Cap Dividends
#1 SMMT leads with +525% December 2022

Among the 3,402 NYSE, Nasdaq and NYSE American stocks currently eligible for this ranking, SMMT (Summit Therapeutics Inc.) has the highest gain in December 2022 with +525%. Following are PHVS (+438%) and MDGL (+297%). Top performing sectors: Consumer Defensive (+83% avg), Healthcare (+75% avg, 7 in top 10), Financial Services (+68% avg, 1 in top 10).

Top Stock Gainers December 2022 - Monthly Performance Ranked

Track the top performing stocks of December 2022 ranked by monthly price gain. See which stock gainers delivered the highest gains this month, with market caps over $100 million on Nasdaq and NYSE.

Best performing large-cap stocks in December 2022

SMMT Summit Therapeutics Inc. +524.91% $10.01B
MDGL Madrigal Pharmaceuticals, Inc. +296.95% $12.42B
ROIV Roivant Sciences Ltd. +37.76% $24.34B
DRS Leonardo DRS, Inc. +32.57% $13.13B
ARWR Arrowhead Pharmaceuticals, ... +26.67% $12.08B
2022
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec

This ranking shows the top performing stocks and biggest stock gainers during December 2022, calculated from the first to the last trading day of the month. It shows which stocks are going up this month, with split-adjusted data used for consistent performance calculations.

Monthly performance rankings can reveal price strength, sustained momentum, sector rotation, and event-driven moves that are not visible in one-day movers lists. The table is informational only and does not recommend any stock to buy, sell, or hold.

December 2022 Stock Market Momentum

This page answers a current-month trend question with data: which NYSE and NASDAQ stocks have shown the strongest price gains so far in December 2022. The ranking is based on observed market performance, not analyst ratings, price targets, or investment recommendations.

Use the list to research momentum, market breadth, sector strength, and catalysts behind large moves. Before acting on any stock, review the company's news, SEC filings, liquidity, volatility, and your own risk constraints.

Looking for a specific Symbol?

December 2022 ranking, complete through December 30, 2022

46 stocks are withheld from this ranking because their price history is under review.

The gain covers the period above. Price, market cap, sector and country show each company as it is today, not as it was then.

Rank
Symbol
Company Name
Dec Gain
Market Cap (today)
Price (today)
Country
Sector
1
SMMT
Summit Therapeutics Inc.
524.91%
10.01 B
$ 12.55
United States
Healthcare
2
PHVS
Pharvaris N.V.
438.28%
2.35 B
$ 33.645
Switzerland
Healthcare
3
MDGL
Madrigal Pharmaceuticals, Inc.
296.95%
12.42 B
$ 538.8
United States
Healthcare
4
ACIC
American Coastal Insurance ...
231.25%
526.32 M
$ 10.86
United States
Financial Services
5
PRQR
ProQR Therapeutics N.V.
203.28%
248.37 M
$ 1.76
Netherlands
Healthcare
6
VKTX
Viking Therapeutics, Inc.
127.6%
4.05 B
$ 34.87
United States
Healthcare
7
RENT
Rent the Runway, Inc.
122.63%
118.56 M
$ 3.53
United States
Consumer Cyclical
8
MSC
Studio City International H...
120.74%
340.88 M
$ 1.77
Hong Kong
Consumer Cyclical
9
PROF
Profound Medical Corp.
120%
263.45 M
$ 7.25
Canada
Healthcare
10
RIGL
Rigel Pharmaceuticals, Inc.
119.27%
712.33 M
$ 38.5
United States
Healthcare
11
WDH
Waterdrop Inc.
105.56%
413.20 M
$ 1.15
China
Financial Services
12
RNA
Atrium Therapeutics, Inc.
99.73%
196.54 M
$ 11.49
United States
Healthcare
13
CABA
Cabaletta Bio, Inc.
97.65%
445.14 M
$ 2.73
United States
Healthcare
14
AKBA
Akebia Therapeutics, Inc.
97.54%
340.69 M
$ 1.27
United States
Healthcare
15
IMMX
Immix Biopharma, Inc.
97.43%
600.84 M
$ 8.44
United States
Healthcare
16
SLNO
Soleno Therapeutics, Inc.
96.04%
2.76 B
$ 53.01
United States
Healthcare
17
VRNA
Verona Pharma plc
90.59%
9.04 B
$ 106.4
United Kingdom
Healthcare
18
GOTU
Gaotu Techedu Inc.
87.3%
383.91 M
$ 1.61
China
Consumer Defensive
19
IQ
iQIYI, Inc.
82.13%
1.21 B
$ 1.25
China
Communication Services
20
EH
EHang Holdings Limited
80.25%
397.43 M
$ 5.24
China
Industrials
21
MAMA
Mama's Creations, Inc.
79.5%
829.51 M
$ 17.84
United States
Consumer Defensive
22
TUYA
Tuya Inc.
73.64%
1.01 B
$ 1.64
China
Technology
23
KRRO
Korro Bio, Inc.
71.88%
151.44 M
$ 10.5
United States
Healthcare
24
CELC
Celcuity Inc.
71.69%
4.02 B
$ 82.46
United States
Healthcare
25
MOMO
Hello Group Inc.
64.17%
868.75 M
$ 5.88
China
Communication Services
26
IPHA
Innate Pharma S.A.
62.88%
157.79 M
$ 1.6803
France
Healthcare
27
ARDX
Ardelyx, Inc.
62.86%
1.26 B
$ 5.085
United States
Healthcare
28
ALVO
Alvotech
62.6%
1.05 B
$ 3.1
Luxembourg
Healthcare
29
WVE
Wave Life Sciences Ltd.
60.92%
1.14 B
$ 5.92
Singapore
Healthcare
30
SY
So-Young International Inc.
60.55%
196.75 M
$ 1.96
China
Healthcare
31
ACLX
Arcellx Inc
57.26%
6.73 B
$ 115.07
United States
Healthcare
32
TUSK
Mammoth Energy Services, Inc.
55.58%
131.02 M
$ 2.72
United States
Industrials
33
RERE
ATRenew Inc.
55.38%
959.06 M
$ 4.33
China
Consumer Cyclical
34
VATE
INNOVATE Corp.
54.55%
116.37 M
$ 8.53
United States
Industrials
35
ETNB
89bio, Inc.
54.12%
1.28 B
$ 8.65
United States
Healthcare
36
BDSX
Biodesix, Inc.
53.33%
217.78 M
$ 21.03
United States
Healthcare
37
ALT
Altimmune, Inc.
52.46%
581.48 M
$ 2.99
United States
Healthcare
38
PMTS
CPI Card Group Inc.
49.4%
242.82 M
$ 21.16
United States
Financial Services
39
HUYA
HUYA Inc.
47.94%
560.69 M
$ 2.44
China
Communication Services
40
TGTX
TG Therapeutics, Inc.
47.51%
8.53 B
$ 55.75
United States
Healthcare
41
TERN
Terns Pharmaceuticals, Inc.
46.05%
6.12 B
$ 52.95
United States
Healthcare
42
ORIC
ORIC Pharmaceuticals, Inc.
45.79%
1.23 B
$ 11.91
United States
Healthcare
43
ORMP
Oramed Pharmaceuticals Inc.
44.24%
170.66 M
$ 4.17
United States
Healthcare
44
PLSE
Pulse Biosciences, Inc.
43.52%
2.45 B
$ 35.47
United States
Healthcare
45
ASRT
Assertio Holdings Inc
43.33%
151.86 M
$ 23.5
United States
Healthcare
46
EOSE
Eos Energy Enterprises, Inc.
42.31%
1.22 B
$ 3.37
United States
Industrials
47
SOUN
SoundHound AI, Inc.
41.6%
2.72 B
$ 6.24
United States
Technology
48
KINS
Kingstone Companies, Inc.
40.64%
292.45 M
$ 20.19
United States
Financial Services
49
VOR
Vor Biopharma Inc.
40%
1.05 B
$ 19.44
United States
Healthcare
50
PTGX
Protagonist Therapeutics, Inc.
39.87%
8.80 B
$ 136.84
United States
Healthcare
51
BILI
Bilibili Inc.
39.19%
7.56 B
$ 18.06
China
Communication Services
52
GDS
GDS Holdings Limited
38.67%
6.14 B
$ 30.62
China
Technology
53
XYF
X Financial
38.53%
191.81 M
$ 4.98
China
Financial Services
54
SGU
Star Group, L.P.
38.19%
415.02 M
$ 12.64
United States
Energy
55
ROIV
Roivant Sciences Ltd.
37.76%
24.34 B
$ 33.84
United Kingdom
Healthcare
56
NINE
Nine Energy Service, Inc.
37.59%
158.89 M
$ 11.39
United States
Energy
57
BLZE
Backblaze, Inc.
37.28%
724.38 M
$ 12.07
United States
Technology
58
EVER
EverQuote, Inc.
36.48%
960.38 M
$ 27.15
United States
Communication Services
59
REPL
Replimune Group, Inc.
36.14%
449.11 M
$ 5.35
United States
Healthcare
60
NIU
Niu Technologies
35.49%
207.86 M
$ 2.65
China
Consumer Cyclical
61
ATXS
Astria Therapeutics, Inc.
35.36%
718.13 M
$ 12.58
United States
Healthcare
62
UAMY
United States Antimony Corp...
35.17%
807.61 M
$ 5.45
United States
Basic Materials
63
PALI
Palisade Bio, Inc.
35.06%
351.03 M
$ 2.02
United States
Healthcare
64
POWL
Powell Industries, Inc.
33.97%
7.32 B
$ 201
United States
Industrials
65
BWAY
BrainsWay Ltd.
33.51%
621.63 M
$ 15.49
Israel
Healthcare
66
API
Agora, Inc.
32.99%
333.13 M
$ 3.94
United States
Technology
67
DRS
Leonardo DRS, Inc.
32.57%
13.13 B
$ 49.21
United States
Industrials
68
MFH
Mercurity Fintech Holding Inc.
32.41%
510.48 M
$ 7.39
United States
Technology
69
CPS
Cooper-Standard Holdings Inc.
31.88%
525.73 M
$ 29.61
United States
Consumer Cyclical
70
DMAC
DiaMedica Therapeutics Inc.
31.68%
357.79 M
$ 6.64
United States
Healthcare
71
SPRY
ARS Pharmaceuticals, Inc.
31.64%
563.05 M
$ 5.67
United States
Healthcare
72
KC
Kingsoft Cloud Holdings Lim...
31.62%
3.03 B
$ 10.11
China
Technology
73
MLCO
Melco Resorts & Entertainme...
31.43%
2.19 B
$ 5.64
Hong Kong
Consumer Cyclical
74
GBTG
Global Business Travel Grou...
31.07%
4.92 B
$ 9.42
United Kingdom
Consumer Cyclical
75
TCMD
Tactile Systems Technology,...
30.6%
625.71 M
$ 27.74
United States
Healthcare
76
LRMR
Larimar Therapeutics, Inc.
30.28%
397.87 M
$ 3.83
United States
Healthcare
77
PPTA
Perpetua Resources Corp.
29.78%
2.18 B
$ 17.39
United States
Basic Materials
78
CYH
Community Health Systems, Inc.
28.19%
393.16 M
$ 2.79
United States
Healthcare
79
QFIN
Qfin Holdings, Inc.
28.05%
1.66 B
$ 13.63
China
Financial Services
80
IMVT
Immunovant, Inc.
27.97%
7.99 B
$ 38.9
United States
Healthcare
81
RZLT
Rezolute, Inc.
27.78%
473.76 M
$ 4.92
United States
Healthcare
82
ZH
Zhihu Inc.
27.45%
279.03 M
$ 3.24
China
Communication Services
83
CVRX
CVRx, Inc.
27.25%
131.35 M
$ 4.95
United States
Healthcare
84
ARWR
Arrowhead Pharmaceuticals, ...
26.67%
12.08 B
$ 85.78
United States
Healthcare
85
KALV
KalVista Pharmaceuticals Inc
26.59%
1.44 B
$ 27
United States
Healthcare
86
SMWB
Similarweb Ltd.
26.57%
629.85 M
$ 7.19
Israel
Technology
87
APYX
Apyx Medical Corporation
26.49%
162.55 M
$ 3.86
United States
Healthcare
88
WB
Weibo Corporation
26.2%
1.92 B
$ 7.81
China
Communication Services
89
MG
Mistras Group, Inc.
26.09%
489.66 M
$ 15.39
United States
Industrials
90
STOK
Stoke Therapeutics, Inc.
25.92%
1.83 B
$ 29.39
United States
Healthcare
91
DLO
DLocal Limited
25.67%
4.38 B
$ 14.88
Uruguay
Technology
92
OPOF
Old Point Financial Corpora...
25.46%
214.80 M
$ 42.1
United States
Financial Services
93
CTLP
Cantaloupe Inc
25.36%
825.82 M
$ 11.2
United States
Technology
94
MDWD
MediWound Ltd.
25.14%
187.90 M
$ 14.62
Israel
Healthcare
95
DCTH
Delcath Systems, Inc.
25%
398.73 M
$ 11.55
United States
Healthcare
96
PLX
Protalix BioTherapeutics, Inc.
24.55%
187.73 M
$ 2.33
United States
Healthcare
97
ADAG
Adagene Inc.
24.41%
246.45 M
$ 3.73
China
Healthcare
98
COFS
ChoiceOne Financial Service...
23.25%
511.90 M
$ 34.24
United States
Financial Services
99
NAMS
NewAmsterdam Pharma Company...
23.16%
3.27 B
$ 27.98
Netherlands
Healthcare
100
WLFC
Willis Lease Finance Corpor...
22.96%
1.68 B
$ 70.47
United States
Industrials
For the most accurate results, consider cross-referencing our data with other sources.

Frequently Asked Questions

Q Which stock has gained the most in December 2022?
A

SMMT (Summit Therapeutics Inc.) has the highest monthly gain in this ranking for December 2022, with a gain of 525%. Top performers this month include SMMT, PHVS, MDGL.

Q What stocks gained the most in December 2022?
A

The biggest gainers in December 2022 were: SMMT (+525%), PHVS (+438%), MDGL (+297%), ACIC (+231%), PRQR (+203%). These monthly rankings show which stocks had the strongest short-term momentum.

Q Does this page recommend the best stocks to buy now?
A

No. This page is an informational ranking of stocks that have already gone up during December 2022. It does not make buy, sell, or hold recommendations and should be used as a research starting point, not financial advice.

Q How can this ranking help explain current stock market trends?
A

The ranking shows where price strength is concentrated during December 2022. Comparing the top gainers by sector, market cap, and recent catalysts can help identify momentum themes and market rotation without implying that any listed stock is a recommendation.

Q Which sectors performed best in December 2022?
A

The top performing sectors in December 2022 included Healthcare, Financial Services, based on the stocks with highest monthly gains. SMMT led the Healthcare sector.

Q How is monthly stock performance calculated?
A

Monthly stock performance is calculated by comparing the closing price on the last trading day of the month to the opening price on the first trading day. Split-adjusted prices ensure accuracy.

Q Where can I find today's top stock gainers and most active stocks?
A

This page ranks stocks by their full-month performance in December 2022. For today's top stock gainers, real-time stock movers, and the most active stocks right now, visit our Momentum Scanner which tracks live intraday market activity across NYSE and NASDAQ.

Understanding Monthly Stock Performance

Monthly performance rankings reveal short-term momentum patterns and help identify stocks experiencing rapid price movements:

  • Momentum Research: Stocks showing strong monthly performance can help identify where market attention and price strength are concentrated.
  • Sector Rotation: Monthly rankings can reveal which sectors are gaining favor with investors and where market leadership is shifting.
  • Event-Driven Moves: Earnings releases, product launches, and regulatory approvals often create significant monthly price movements.

Using Monthly Data Effectively

  • Combine Timeframes: Compare monthly gainers with 52-week and YTD performance to identify stocks with both short and long-term momentum.
  • Research the Catalyst: Investigate why top monthly performers moved significantly. The reason for the move matters as much as the percentage gain.
  • Watch for Reversals: Extreme monthly gains sometimes precede corrections, so treat the ranking as a research starting point rather than a buy list.

Evaluate Your Positions

Researching one of this month's top movers? Use our Stock Return Calculator to review historical performance, or the Position Size Calculator to model position sizing and risk before making your own decision.