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MARKET LEADERS
52-WEEK LEADER
WOLF +3311%
Wolfspeed, Inc.
2022 YTD LEADER
BEAG +9999%
Bold Eagle Acquisition..
DEC 2022 LEADER
RGC +3541%
Regencell Bioscience H..
📈 52-Week Top 5 Full List →
1 WOLF +3311.2% 2 BW +1169.7% 3 BE +1052.3% 4 CIEN +508.3% 5 TE +495.8%
📅 2022 YTD Top 5 Full List →
1 BEAG +9999.0% 2 SNWV +8441.2% 3 META +3733.4% 4 CLS +3217.2% 5 STRL +3031.3%
🗓 December 2022 Top 5 Full List →
1 RGC +3541.0% 2 SMMT +524.9% 3 PHVS +438.3% 4 MDGL +296.9% 5 ACIC +231.3%
Quick Access: 52-Week 2022 YTD Dec 2022 Market Cap Dividends
#1 RGC leads with +3,541% December 2022

RGC (Regencell Bioscience Holdings Limited) is the best performing stock in December 2022. Following are SMMT (+525%) and PHVS (+438%). Top performing sectors: Healthcare (+147% avg, 7 in top 10), Financial Services (+68% avg, 1 in top 10), Consumer Defensive (+65% avg).

Top Stock Gainers December 2022 - Monthly Performance Ranked

Track the top performing stocks of December 2022 ranked by monthly price gain. See which stock gainers delivered the highest gains this month, with market caps over $100 million on Nasdaq and NYSE.
2022
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec

This ranking shows the top performing stocks and biggest stock gainers during December 2022, calculated from the first to the last trading day of the month. It shows which stocks are going up this month, with split-adjusted data used for consistent performance calculations.

Monthly performance rankings can reveal price strength, sustained momentum, sector rotation, and event-driven moves that are not visible in one-day movers lists. The table is informational only and does not recommend any stock to buy, sell, or hold.

December 2022 Stock Market Momentum

This page answers a current-month trend question with data: which NYSE and NASDAQ stocks have shown the strongest price gains so far in December 2022. The ranking is based on observed market performance, not analyst ratings, price targets, or investment recommendations.

Use the list to research momentum, market breadth, sector strength, and catalysts behind large moves. Before acting on any stock, review the company's news, SEC filings, liquidity, volatility, and your own risk constraints.

Looking for a specific Symbol?

Data as of June 9, 2026 at 7:49 PM EDT

Rank
Symbol
Company Name
Dec Gain
Market Cap
Price
Country
Sector
1
RGC
Regencell Bioscience Holdin...
3540.99%
10.58 B
$ 21.39
Hong Kong
Healthcare
2
SMMT
Summit Therapeutics Inc.
524.91%
10.95 B
$ 14.11
United States
Healthcare
3
PHVS
Pharvaris N.V.
438.28%
2.21 B
$ 31.59
Switzerland
Healthcare
4
MDGL
Madrigal Pharmaceuticals, Inc.
296.95%
10.77 B
$ 467.28
United States
Healthcare
5
ACIC
American Coastal Insurance ...
231.25%
494.82 M
$ 10.21
United States
Financial Services
6
PRQR
ProQR Therapeutics N.V.
203.28%
161.20 M
$ 1.53
Netherlands
Healthcare
7
VKTX
Viking Therapeutics, Inc.
127.6%
3.39 B
$ 29.24
United States
Healthcare
8
RENT
Rent the Runway, Inc.
122.63%
113.52 M
$ 3.38
United States
Consumer Cyclical
9
MSC
Studio City International H...
120.74%
450.64 M
$ 2.3399
Hong Kong
Consumer Cyclical
10
PROF
Profound Medical Corp.
120%
238.74 M
$ 6.57
Canada
Healthcare
11
RIGL
Rigel Pharmaceuticals, Inc.
119.27%
556.54 M
$ 30.08
United States
Healthcare
12
WDH
Waterdrop Inc.
105.56%
503.02 M
$ 1.4
China
Financial Services
13
RNA
Atrium Therapeutics, Inc.
99.73%
197.57 M
$ 11.55
United States
Healthcare
14
CABA
Cabaletta Bio, Inc.
97.65%
521.78 M
$ 3.2
United States
Healthcare
15
AKBA
Akebia Therapeutics, Inc.
97.54%
250.98 M
$ 0.9356
United States
Healthcare
16
IMMX
Immix Biopharma, Inc.
97.43%
560.26 M
$ 7.87
United States
Healthcare
17
SLNO
Soleno Therapeutics, Inc.
96.04%
2.76 B
$ 53.01
United States
Healthcare
18
VRNA
Verona Pharma plc
90.59%
9.04 B
$ 106.4
United Kingdom
Healthcare
19
GOTU
Gaotu Techedu Inc.
87.3%
360.07 M
$ 1.51
China
Consumer Defensive
20
IQ
iQIYI, Inc.
82.13%
1.01 B
$ 1.05
China
Communication Services
21
EH
EHang Holdings Limited
80.25%
660.61 M
$ 8.71
China
Industrials
22
MAMA
Mama's Creations, Inc.
79.5%
618.75 M
$ 15.2
United States
Consumer Defensive
23
TUYA
Tuya Inc.
73.64%
1.18 B
$ 1.93
China
Technology
24
KRRO
Korro Bio, Inc.
71.88%
152.74 M
$ 10.59
United States
Healthcare
25
CELC
Celcuity Inc.
71.69%
4.26 B
$ 87.43
United States
Healthcare
26
MOMO
Hello Group Inc.
64.17%
822.95 M
$ 5.57
China
Communication Services
27
IPHA
Innate Pharma S.A.
62.88%
165.27 M
$ 1.76
France
Healthcare
28
ARDX
Ardelyx, Inc.
62.86%
1.37 B
$ 5.54
United States
Healthcare
29
ALVO
Alvotech
62.6%
1.32 B
$ 4.24
Luxembourg
Healthcare
30
WVE
Wave Life Sciences Ltd.
60.92%
1.10 B
$ 5.7
Singapore
Healthcare
31
SY
So-Young International Inc.
60.55%
183.70 M
$ 1.83
China
Healthcare
32
ACLX
Arcellx Inc
57.26%
6.73 B
$ 115.07
United States
Healthcare
33
TUSK
Mammoth Energy Services, Inc.
55.58%
167.63 M
$ 3.48
United States
Industrials
34
RERE
ATRenew Inc.
55.38%
912.54 M
$ 4.12
China
Consumer Cyclical
35
VATE
INNOVATE Corp.
54.55%
260.56 M
$ 19.1
United States
Industrials
36
ETNB
89bio, Inc.
54.12%
1.28 B
$ 8.65
United States
Healthcare
37
BDSX
Biodesix, Inc.
53.33%
154.82 M
$ 14.95
United States
Healthcare
38
ALT
Altimmune, Inc.
52.46%
530.91 M
$ 2.73
United States
Healthcare
39
PMTS
CPI Card Group Inc.
49.4%
195.54 M
$ 17.04
United States
Financial Services
40
HUYA
HUYA Inc.
47.94%
572.18 M
$ 2.49
China
Communication Services
41
TGTX
TG Therapeutics, Inc.
47.51%
6.27 B
$ 40.95
United States
Healthcare
42
TERN
Terns Pharmaceuticals, Inc.
46.05%
6.12 B
$ 52.95
United States
Healthcare
43
ORIC
ORIC Pharmaceuticals, Inc.
45.79%
779.49 M
$ 7.53
United States
Healthcare
44
ORMP
Oramed Pharmaceuticals Inc.
44.24%
148.97 M
$ 3.64
United States
Healthcare
45
PLSE
Pulse Biosciences, Inc.
43.52%
1.72 B
$ 24.84
United States
Healthcare
46
ASRT
Assertio Holdings, Inc.
43.33%
151.41 M
$ 23.43
United States
Healthcare
47
EOSE
Eos Energy Enterprises, Inc.
42.31%
2.27 B
$ 6.69
United States
Industrials
48
SOUN
SoundHound AI, Inc.
41.6%
3.24 B
$ 7.49
United States
Technology
49
KINS
Kingstone Companies, Inc.
40.64%
225.09 M
$ 15.54
United States
Financial Services
50
VOR
Vor Biopharma Inc.
40%
720.13 M
$ 13.29
United States
Healthcare
51
PTGX
Protagonist Therapeutics, Inc.
39.87%
6.30 B
$ 98.03
United States
Healthcare
52
BILI
Bilibili Inc.
39.19%
7.49 B
$ 17.96
China
Communication Services
53
GDS
GDS Holdings Limited
38.67%
6.95 B
$ 34.69
China
Technology
54
XYF
X Financial
38.53%
186.42 M
$ 4.84
China
Financial Services
55
SGU
Star Group, L.P.
38.19%
416.99 M
$ 12.7
United States
Energy
56
ROIV
Roivant Sciences Ltd.
37.76%
20.49 B
$ 28.49
United Kingdom
Healthcare
57
NINE
Nine Energy Service, Inc.
37.59%
442.36 M
$ 10.21
United States
Energy
58
BLZE
Backblaze, Inc.
37.28%
456.11 M
$ 7.6
United States
Technology
59
EVER
EverQuote, Inc.
36.48%
682.70 M
$ 19.3
United States
Communication Services
60
REPL
Replimune Group, Inc.
36.14%
740.68 M
$ 8.97
United States
Healthcare
61
NIU
Niu Technologies
35.49%
179.62 M
$ 2.29
China
Consumer Cyclical
62
ATXS
Astria Therapeutics, Inc.
35.36%
718.13 M
$ 12.58
United States
Healthcare
63
UAMY
United States Antimony Corp...
35.17%
1.16 B
$ 7.81
United States
Basic Materials
64
PALI
Palisade Bio, Inc.
35.06%
302.38 M
$ 1.74
United States
Healthcare
65
POWL
Powell Industries, Inc.
33.97%
10.70 B
$ 293.6
United States
Industrials
66
BWAY
BrainsWay Ltd.
33.51%
577.73 M
$ 14.41
Israel
Healthcare
67
API
Agora, Inc.
32.99%
388.08 M
$ 4.59
United States
Technology
68
DRS
Leonardo DRS, Inc.
32.57%
12.42 B
$ 46.55
United States
Industrials
69
MFH
Mercurity Fintech Holding Inc.
32.41%
510.48 M
$ 7.39
United States
Technology
70
CPS
Cooper-Standard Holdings Inc.
31.88%
519.52 M
$ 29.26
United States
Consumer Cyclical
71
DMAC
DiaMedica Therapeutics Inc.
31.68%
302.29 M
$ 5.61
United States
Healthcare
72
SPRY
ARS Pharmaceuticals, Inc.
31.64%
892.74 M
$ 8.99
United States
Healthcare
73
KC
Kingsoft Cloud Holdings Lim...
31.62%
3.40 B
$ 11.37
China
Technology
74
MLCO
Melco Resorts & Entertainme...
31.43%
2.31 B
$ 5.95
Hong Kong
Consumer Cyclical
75
GBTG
Global Business Travel Grou...
31.07%
4.88 B
$ 9.35
United Kingdom
Consumer Cyclical
76
TCMD
Tactile Systems Technology,...
30.6%
569.55 M
$ 25.25
United States
Healthcare
77
LRMR
Larimar Therapeutics, Inc.
30.28%
322.04 M
$ 3.1
United States
Healthcare
78
PPTA
Perpetua Resources Corp.
29.78%
2.87 B
$ 22.91
United States
Basic Materials
79
TAL
TAL Education Group
28.88%
5.73 B
$ 9.41
China
Consumer Defensive
80
CYH
Community Health Systems, Inc.
28.19%
388.93 M
$ 2.76
United States
Healthcare
81
QFIN
Qfin Holdings, Inc.
28.05%
1.74 B
$ 14.27
China
Financial Services
82
IMVT
Immunovant, Inc.
27.97%
6.32 B
$ 30.8
United States
Healthcare
83
RZLT
Rezolute, Inc.
27.78%
392.87 M
$ 4.08
United States
Healthcare
84
ZH
Zhihu Inc.
27.45%
282.94 M
$ 3.26
China
Communication Services
85
CVRX
CVRx, Inc.
27.25%
143.29 M
$ 5.4
United States
Healthcare
86
ARWR
Arrowhead Pharmaceuticals, ...
26.67%
10.40 B
$ 73.86
United States
Healthcare
87
KALV
KalVista Pharmaceuticals, Inc.
26.59%
1.44 B
$ 26.99
United States
Healthcare
88
SMWB
Similarweb Ltd.
26.57%
361.79 M
$ 4.13
Israel
Technology
89
APYX
Apyx Medical Corporation
26.49%
199.74 M
$ 4.77
United States
Healthcare
90
REKR
Rekor Systems, Inc.
26.3%
101.57 M
$ 0.7381
United States
Technology
91
FRGE
Forge Global Holdings Inc
26.28%
623.01 M
$ 45
United States
Financial Services
92
WB
Weibo Corporation
26.2%
1.88 B
$ 7.64
China
Communication Services
93
MG
Mistras Group, Inc.
26.09%
570.79 M
$ 17.94
United States
Industrials
94
STOK
Stoke Therapeutics, Inc.
25.92%
1.81 B
$ 29
United States
Healthcare
95
NRP
Natural Resource Partners L.P.
25.91%
1.38 B
$ 104.5
United States
Energy
96
DLO
DLocal Limited
25.67%
3.38 B
$ 11.49
Uruguay
Technology
97
IOT
Samsara Inc.
25.56%
19.85 B
$ 34.06
United States
Technology
98
OPOF
Old Point Financial Corpora...
25.46%
214.80 M
$ 42.1
United States
Financial Services
99
CTLP
Cantaloupe Inc
25.36%
825.82 M
$ 11.2
United States
Technology
100
MDWD
MediWound Ltd.
25.14%
182.63 M
$ 14.21
Israel
Healthcare
For the most accurate results, consider cross-referencing our data with other sources.

Frequently Asked Questions

Q Which stock has gained the most in December 2022?
A

RGC (Regencell Bioscience Holdings Limited) has the highest monthly gain in this ranking for December 2022, with a gain of 3,541%. Top performers this month include RGC, SMMT, PHVS.

Q What stocks gained the most in December 2022?
A

The biggest gainers in December 2022 were: RGC (+3,541%), SMMT (+525%), PHVS (+438%), MDGL (+297%), ACIC (+231%). These monthly rankings show which stocks had the strongest short-term momentum.

Q Does this page recommend the best stocks to buy now?
A

No. This page is an informational ranking of stocks that have already gone up during December 2022. It does not make buy, sell, or hold recommendations and should be used as a research starting point, not financial advice.

Q How can this ranking help explain current stock market trends?
A

The ranking shows where price strength is concentrated during December 2022. Comparing the top gainers by sector, market cap, and recent catalysts can help identify momentum themes and market rotation without implying that any listed stock is a recommendation.

Q Which sectors performed best in December 2022?
A

The top performing sectors in December 2022 included Healthcare, Financial Services, based on the stocks with highest monthly gains. RGC led the Healthcare sector.

Q How is monthly stock performance calculated?
A

Monthly stock performance is calculated by comparing the closing price on the last trading day of the month to the opening price on the first trading day. Split-adjusted prices ensure accuracy.

Q Where can I find today's top stock gainers and most active stocks?
A

This page ranks stocks by their full-month performance in December 2022. For today's top stock gainers, real-time stock movers, and the most active stocks right now, visit our Momentum Scanner which tracks live intraday market activity across NYSE and NASDAQ.

Understanding Monthly Stock Performance

Monthly performance rankings reveal short-term momentum patterns and help identify stocks experiencing rapid price movements:

  • Momentum Research: Stocks showing strong monthly performance can help identify where market attention and price strength are concentrated.
  • Sector Rotation: Monthly rankings can reveal which sectors are gaining favor with investors and where market leadership is shifting.
  • Event-Driven Moves: Earnings releases, product launches, and regulatory approvals often create significant monthly price movements.

Using Monthly Data Effectively

  • Combine Timeframes: Compare monthly gainers with 52-week and YTD performance to identify stocks with both short and long-term momentum.
  • Research the Catalyst: Investigate why top monthly performers moved significantly. The reason for the move matters as much as the percentage gain.
  • Watch for Reversals: Extreme monthly gains sometimes precede corrections, so treat the ranking as a research starting point rather than a buy list.

Evaluate Your Positions

Researching one of this month's top movers? Use our Stock Return Calculator to review historical performance, or the Position Size Calculator to model position sizing and risk before making your own decision.