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Recursion Announces Webinar For Upcoming Clinical Data Readout on the TUPELO Phase 1b/2 Trial of REC-4881 in Familial Adenomatous Polyposis on December 8, 2025

Recursion (Nasdaq: RXRX) will host a webinar on December 8, 2025 to present an updated clinical readout from the ongoing TUPELO Phase 1b/2 trial of REC-4881 in familial adenomatous polyposis (FAP).

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Recursion (Nasdaq: RXRX) will host a webinar on December 8, 2025 to present an updated clinical readout from the ongoing TUPELO Phase 1b/2 trial of REC-4881 in familial adenomatous polyposis (FAP).

The live webinar is scheduled for 8:00 AM ET / 6:00 AM MT / 1:00 PM GMT and will stream on Recursion's X, LinkedIn, and YouTube channels. The session is titled: Ongoing Phase 1b/2 Trial of the Allosteric MEK1/2 Inhibitor REC-4881 as Monotherapy in Familial Adenomatous Polyposis (FAP): Updated Safety and Efficacy.

Presenters include Najat Khan, Ph.D. (incoming CEO and President), David Mauro, M.D., Ph.D., Beth Bruckheimer, Ph.D., Jessica Stout, D.O., and Alfred Cohen, M.D.

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Argus Dec 1 session
-5.83% close to close Open Argus
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News Market Reaction – RXRX

On Dec 1, the day this news came out, RXRX closed 5.83% below the previous close.

Data tracked by StockTitan Argus for the Dec 1 session.

Key Figures

Webinar date: December 8, 2025 Webinar time ET: 8:00 am ET Trial phase: Phase 1b/2 +2 more
Webinar date
December 8, 2025
REC-4881 TUPELO Phase 1b/2 clinical data readout
Webinar time ET
8:00 am ET
Scheduled start time of REC-4881 TUPELO webinar
Trial phase
Phase 1b/2
TUPELO trial of REC-4881 in FAP
Share price
$4.57
Price prior to webinar announcement impact assessment
52-week range
$3.79–$12.36
Positioned closer to 52-week low than high

Historical Context

5 past events · Latest: Dec 08
5 events
  1. Dec 08

    REC-4881 TUPELO data

    24h Move
    +2.3%

    Positive REC-4881 TUPELO Phase 1b/2 FAP data with durable polyp reductions.

  2. Dec 01

    Webinar announcement

    24h Move
    -5.8%

    Announcement of Dec 8 webinar to present updated REC-4881 TUPELO trial data.

  3. Nov 05

    Q3 2025 earnings

    24h Move
    -0.8%

    Q3 2025 results with lower revenue, high R&D spend, and sizable net loss.

  4. Nov 05

    CEO transition plan

    24h Move
    -0.8%

    Planned transition of Najat Khan to CEO and Chris Gibson to Board Chair.

  5. Nov 04

    Investor conferences

    24h Move
    -8.1%

    Participation in November healthcare investor conferences and webcast availability.

24h Move is the share-price change in the day after each event; other market factors may also have contributed.

Key Terms

phase 1b/2, allosteric, mek1/2 inhibitor, familial adenomatous polyposis
4 terms
phase 1b/2 medical
"new clinical readout from the ongoing TUPELO Phase 1b/2 trial of REC-4881"
Phase 1b/2 is a combined early-stage human study that first checks a drug’s safety and side effects in a small group and then expands to test whether it shows signs of working in patients. Think of it as a product test that first confirms it’s safe to use, then looks for early evidence of benefit; positive results can significantly reduce clinical risk and increase a company’s value, while negative results raise the opposite.
allosteric medical
"Ongoing Phase 1b/2 Trial of the Allosteric MEK1/2 Inhibitor REC-4881"
Allosteric describes a way drugs or molecules change a biological target’s behavior by attaching at a spot separate from the main active site, causing the target to shift shape and work differently. For investors, allosteric mechanisms can mean more precise drugs with fewer side effects, fresh patent pathways and differentiated market potential, because they can fine-tune a target rather than simply switching it fully on or off—like using a dimmer knob instead of a basic light switch.
mek1/2 inhibitor medical
"Trial of the Allosteric MEK1/2 Inhibitor REC-4881 as Monotherapy"
A MEK1/2 inhibitor is a drug that blocks two enzymes, MEK1 and MEK2, which act as switches in a cell’s growth-signaling pathway; blocking them is like turning off a faulty speed dial on an assembly line so cells slow or stop dividing. For investors, these drugs matter because their success or failure in clinical trials and regulatory review can determine a therapy’s commercial value, market size, and the prospects of companies developing targeted treatments for specific patient groups.
familial adenomatous polyposis medical
"REC-4881 in Familial Adenomatous Polyposis (FAP) at an upcoming company webinar."
An inherited condition caused by a gene mutation that leads to the early development of hundreds to thousands of growths (polyps) in the colon and rectum, which, if untreated, almost always progress to colorectal cancer. Investors care because it creates a clear medical need for genetic testing, ongoing monitoring, preventive surgeries and targeted therapies; like a high-risk household where early alarms and durable fixes have outsized value in diagnostics and treatment markets.

AI-generated analysis. How Rhea-AI works. Not financial advice.

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Salt Lake City, Dec. 01, 2025 (GLOBE NEWSWIRE) -- Recursion (Nasdaq: RXRX) a leading clinical stage TechBio company decoding biology to radically improve lives, announced today that it will present a new clinical readout from the ongoing TUPELO Phase 1b/2 trial of REC-4881 in FAP at an upcoming company webinar. The webinar will be held on December 8, 2025 at 8:00 am ET / 6:00 am MT / 1:00 pm GMT, and will be streamed live on Recursion’s X, LinkedIn, and YouTube accounts. 

Webinar title: Ongoing Phase 1b/2 Trial of the Allosteric MEK1/2 Inhibitor REC-4881 as Monotherapy in Familial Adenomatous Polyposis (FAP): Updated Safety and Efficacy

Presenters: 

  • Najat Khan, Ph.D., Chief R&D and Chief Commercial Officer and incoming CEO and President, Recursion
  • David Mauro, M.D., Ph.D., Chief Medical Officer, Recursion
  • Beth Bruckheimer, Ph.D., Vice President of Clinical Development, Recursion
  • Jessica Stout, D.O., Assistant Clinical Professor, University of Utah School of Medicine
  • Alfred Cohen, M.D., Former CMO, Cancer Prevention Pharmaceuticals; Prior Chief, Colorectal Service, Memorial Sloan Kettering Cancer Center

About Recursion
Recursion (NASDAQ: RXRX) is a clinical stage TechBio company leading the space by decoding biology to radically improve lives. Enabling its mission is the Recursion OS, a platform built across diverse technologies that continuously generate one of the world’s largest proprietary biological and chemical datasets. Recursion leverages sophisticated machine-learning algorithms to distill from its dataset a collection of trillions of searchable relationships across biology and chemistry unconstrained by human bias. By commanding massive experimental scale — up to millions of wet lab experiments weekly — and massive computational scale — owning and operating one of the most powerful supercomputers in the world, Recursion is uniting technology, biology and chemistry to advance the future of medicine.

Recursion is headquartered in Salt Lake City, where it is a founding member of BioHive, the Utah life sciences industry collective. Recursion also has offices in Montréal, New York, London, and the Oxford area. Learn more at www.recursion.com, or connect on X and LinkedIn.

Forward-Looking Statements
This document contains information that includes or is based upon “forward-looking statements” within the meaning of the Securities Litigation Reform Act of 1995, including, without limitation, those regarding the timing of the announcement of clinical trial data and associated webinar and scheduled presenters; early and late stage discovery, preclinical, and clinical programs; licenses and collaborations; prospective products and their potential future indications and market opportunities; Recursion OS and other technologies; business and financial plans and performance; and all other statements that are not historical facts. Forward-looking statements may or may not include identifying words such as “plan,” “will,” “expect,” “anticipate,” “intend,” “believe,” “potential,” “continue,” and similar terms. These statements are subject to known or unknown risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements, including but not limited to: challenges inherent in pharmaceutical research and development, including the timing and results of preclinical and clinical programs, where the risk of failure is high and failure can occur at any stage prior to or after regulatory approval due to lack of sufficient efficacy, safety considerations, or other factors; our ability to leverage and enhance our drug discovery platform; our ability to obtain financing for development activities and other corporate purposes; the success of our collaboration activities; our ability to obtain regulatory approval of, and ultimately commercialize, drug candidates; our ability to obtain, maintain, and enforce intellectual property protections; cyberattacks or other disruptions to our technology systems; our ability to attract, motivate, and retain key employees and manage our growth; inflation and other macroeconomic issues; and other risks and uncertainties such as those described under the heading “Risk Factors” in our filings with the U.S. Securities and Exchange Commission, including our Annual Report on Form 10-K and Quarterly Reports on Form 10-Q. All forward-looking statements are based on management’s current estimates, projections, and assumptions, and Recursion undertakes no obligation to correct or update any such statements, whether as a result of new information, future developments, or otherwise, except to the extent required by applicable law.



Investor Contact
investor@recursion.com

Media Contact
media@recursion.com

FAQ

AI-generated questions and answers. How Rhea-AI works. Not financial advice.

When is the Recursion (RXRX) webinar presenting TUPELO trial data for REC-4881?

The webinar is on December 8, 2025 at 8:00 AM ET / 6:00 AM MT / 1:00 PM GMT.

How can investors watch the RXRX TUPELO trial readout webinar on December 8, 2025?

The presentation will stream live on Recursion's X, LinkedIn, and YouTube accounts.

What will Recursion (RXRX) present about REC-4881 in the December 8, 2025 webinar?

The webinar will present an updated safety and efficacy readout from the ongoing TUPELO Phase 1b/2 trial in FAP.

Who are the presenters at the RXRX REC-4881 TUPELO webinar on December 8, 2025?

Presenters include Najat Khan, Ph.D. (incoming CEO and President), David Mauro, M.D., Ph.D., Beth Bruckheimer, Ph.D., Jessica Stout, D.O., and Alfred Cohen, M.D..

What is the clinical focus of REC-4881 being discussed by Recursion (RXRX)?

REC-4881 is an allosteric MEK1/2 inhibitor being evaluated as monotherapy in patients with familial adenomatous polyposis (FAP) in the TUPELO trial.

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