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Top Healthcare Stocks by R&D Spending

Top healthcare companies ranked by R&D spending, latest annual filings.

What R&D Spending Means for Healthcare Companies

R&D spending in healthcare funds the clinical pipeline, from preclinical discovery through late-stage trials and regulatory submission. Pharma and biotech expense this work immediately even though trials run for years and the economic payoff, if it comes, arrives only after approval. The result is a line item that can dwarf reported earnings at small developers and compound into billions annually at integrated pharma, while pure-play device makers spend on a steadier rhythm.

Why It Matters in Healthcare

The pipeline is the business, so sustained R&D is a proxy for future revenue once the current portfolio faces patent cliffs or reimbursement pressure. A deep late-stage pipeline tends to attract premium valuations because the regulatory moat, once earned, is durable. Yet absolute dollars can mislead; clinical failure rates are high, and a firm concentrating spend on a few late-stage programs faces different risk than one running a broader early-stage portfolio.

What to Read Alongside

Read R&D alongside Revenue to gauge how much of current sales is being reinvested, Net Income to see the earnings drag at developmental firms, and Free Cash Flow to judge funding durability.

Data as of FY 2025 100 companies Rhea AI
# Symbol Company Sector
1 MRK Merck & Co., Inc. Healthcare $15.79B $361.73B
2 JNJ Johnson & Johnson Healthcare $14.66B $664.95B
3 AZN AstraZeneca PLC Healthcare $14.23B $289.14B
4 LLY Eli Lilly and Company Healthcare $13.34B $1.21T
5 NVS Novartis AG Healthcare $11.20B $307.00B
6 PFE Pfizer Inc. Healthcare $10.44B $167.52B
7 GSK GSK plc Healthcare $10.12B $100.88B
8 BMY Bristol-Myers Squibb Company Healthcare $9.95B $127.02B
9 SNY Sanofi Healthcare $9.20B $112.71B
10 ABBV AbbVie Inc. Healthcare $9.10B $514.78B
11 NVO Novo Nordisk A/S Healthcare $8.18B $177.74B
12 AMGN Amgen Inc. Healthcare $7.27B $249.05B
13 REGN Regeneron Pharmaceuticals, Inc. Healthcare $5.85B $93.55B
14 GILD Gilead Sciences, Inc. Healthcare $5.80B $207.00B
15 TAK Takeda Pharmaceutical Company Limited Healthcare $4.25B $67.16B
16 VRTX Vertex Pharmaceuticals Incorporated Healthcare $3.91B $138.71B
17 MRNA Moderna, Inc. Healthcare $3.13B $101.48B
18 ABT Abbott Laboratories Healthcare $2.94B $190.43B
19 MDT Medtronic plc Healthcare $2.87B $130.22B
20 BNTX BioNTech SE Healthcare $2.47B $21.70B
21 ONC BeOne Medicines AG Healthcare $2.15B $46.30B
22 BSX Boston Scientific Corporation Healthcare $2.05B $61.96B
23 INCY Incyte Corporation Healthcare $2.05B $24.39B
24 PHG Koninklijke Philips N.V. Healthcare $2.00B $29.67B
25 BIIB Biogen Inc. Healthcare $1.78B $36.71B
26 SYK Stryker Corporation Healthcare $1.62B $124.06B
27 GMAB Genmab A/S Healthcare $1.61B $32.98B
28 DHR Danaher Corporation Healthcare $1.60B $161.89B
29 SRPT Sarepta Therapeutics, Inc. Healthcare $1.52B $1.88B
30 TMO Thermo Fisher Scientific Inc. Healthcare $1.40B $257.42B
31 ARGX argenx SE Healthcare $1.36B $58.31B
32 ALNY Alnylam Pharmaceuticals, Inc. Healthcare $1.32B $20.89B
33 ISRG Intuitive Surgical, Inc. Healthcare $1.31B $159.96B
34 BDX Becton, Dickinson and Company Healthcare $1.26B $57.71B
35 GEHC GE HealthCare Technologies Inc. Healthcare $1.26B $37.25B
36 EW Edwards Lifesciences Corporation Healthcare $1.08B $58.73B
37 NBIX Neurocrine Biosciences, Inc. Healthcare $1.02B $16.66B
38 TEVA Teva Pharmaceutical Industries Limited Healthcare $1.01B $49.72B
39 ALC Alcon Inc. Healthcare $990.00M $36.23B
40 RVMD Revolution Medicines, Inc. Healthcare $987.33M $41.59B
41 ILMN Illumina, Inc. Healthcare $967.00M $32.23B
42 VTRS Viatris Inc. Healthcare $965.90M $22.87B
43 BMRN BioMarin Pharmaceutical Inc. Healthcare $921.93M $10.85B
44 IONS Ionis Pharmaceuticals, Inc. Healthcare $915.62M $6.55B
45 EXEL Exelixis, Inc. Healthcare $825.00M $16.98B
46 PCVX Vaxcyte, Inc. Healthcare $794.31M $10.11B
47 JAZZ Jazz Pharmaceuticals plc Healthcare $782.74M $15.07B
48 INSM Insmed Incorporated Healthcare $771.09M $25.10B
49 VEEV Veeva Systems Inc. Healthcare $767.39M $49.18B
50 RARE Ultragenyx Pharmaceutical Inc. Healthcare $750.00M $1.57B
51 SOLV Solventum Corporation Healthcare $739.00M $15.38B
52 ZTS Zoetis Inc. Healthcare $698.00M $32.81B
53 ROIV Roivant Sciences Ltd. Healthcare $681.81M $28.08B
54 BHVN Biohaven Ltd. Healthcare $635.07M $2.19B
55 BHC Bausch Health Companies Inc. Healthcare $629.00M $3.06B
56 NTRA Natera, Inc. Healthcare $624.11M $44.78B
57 ARWR Arrowhead Pharmaceuticals, Inc. Healthcare $607.16M $8.22B
58 DXCM DexCom, Inc. Healthcare $599.10M $29.62B
59 UTHR United Therapeutics Corporation Healthcare $550.00M $23.94B
60 LKFT Lakefront Biotherapeutics NV Healthcare $539.18M $2.20B
61 SMMT Summit Therapeutics Inc. Healthcare $537.67M $13.06B
62 RCUS Arcus Biosciences, Inc. Healthcare $523.00M $2.63B
63 BAX Baxter International Inc. Healthcare $518.00M $13.34B
64 GRFS Grifols, S.A. Healthcare $499.95M $5.74B
65 RXRX Recursion Pharmaceuticals, Inc. Healthcare $475.27M $2.19B
66 ZBH Zimmer Biomet Holdings, Inc. Healthcare $458.50M $19.98B
67 IMVT Immunovant, Inc. Healthcare $456.66M $6.31B
68 VIR Vir Biotechnology, Inc. Healthcare $455.97M $2.09B
69 PTCT PTC Therapeutics, Inc. Healthcare $455.25M $5.47B
70 A Agilent Technologies, Inc. Healthcare $455.00M $49.26B
71 RPRX Royalty Pharma plc Healthcare $452.00M $38.60B
72 BBIO BridgeBio Pharma, Inc. Healthcare $451.95M $14.47B
73 MMED MiniMed Group, Inc. Healthcare $448.00M $4.70B
74 HLN Haleon plc Healthcare $424.93M $40.17B
75 DNLI Denali Therapeutics Inc. Healthcare $418.78M $3.22B
76 CYTK Cytokinetics, Incorporated Healthcare $416.03M $7.48B
77 LEGN Legend Biotech Corporation Healthcare $414.70M $4.55B
78 BEAM Beam Therapeutics Inc. Healthcare $409.62M $2.73B
79 DYN Dyne Therapeutics, Inc. Healthcare $398.33M $3.37B
80 BRKR Bruker Corporation Healthcare $395.20M $9.34B
81 NTLA Intellia Therapeutics, Inc. Healthcare $388.86M $1.59B
82 MDGL Madrigal Pharmaceuticals, Inc. Healthcare $388.52M $9.28B
83 ALMS Alumis Inc. Healthcare $386.00M $780.49M
84 RMD ResMed Inc. Healthcare $378.29M $33.10B
85 BLCO Bausch + Lomb Corporation Healthcare $371.00M $7.15B
86 ALGN Align Technology, Inc. Healthcare $369.91M $11.70B
87 HNGE Hinge Health, Inc. Healthcare $368.14M $9.34B
88 ELAN Elanco Animal Health Incorporated Healthcare $368.00M $12.86B
89 OGN Organon & Co. Healthcare $366.00M $3.64B
90 GH Guardant Health, Inc. Healthcare $364.19M $20.25B
91 ASND Ascendis Pharma A/S Healthcare $356.33M $16.90B
92 VKTX Viking Therapeutics, Inc. Healthcare $344.95M $3.42B
93 NVAX Novavax, Inc. Healthcare $342.32M $1.78B
94 AGIO Agios Pharmaceuticals, Inc. Healthcare $339.54M $1.76B
95 VRDN Viridian Therapeutics, Inc. Healthcare $338.93M $3.24B
96 ACAD Acadia Pharmaceuticals Inc. Healthcare $328.80M $3.66B
97 ALKS Alkermes plc Healthcare $323.96M $7.71B
98 VOR Vor Biopharma Inc. Healthcare $321.53M $1.22B
99 NRIX Nurix Therapeutics, Inc. Healthcare $316.90M $1.67B
100 KYMR Kymera Therapeutics, Inc. Healthcare $316.57M $11.25B

How this ranking is built

Companies are ranked by R&D spending as reported in their most recent annual filing with the SEC. Figures shown are in US dollars (or percent, as noted), rounded to two decimals.

  • Source: annual 10-K / 20-F filings from companies trading on US exchanges (NYSE, Nasdaq, AMEX).
  • Fiscal year: whichever annual period the company has most recently filed. Fiscal years don't always align with the calendar year, so the "as of FY" stamp above reflects the most common year across the table.
  • Filtered out: warrants, preferred shares, and duplicate listings that share a parent company's financials.
  • Size floor: A company qualifies at $500 million in market cap or above. Below that, one mis-stated figure outranks the companies the list is about.
  • Currency check: A company whose annual revenue runs above 15 times its market cap is left out, because at that gap the two figures are not in the same currency.
  • Currency check: A company whose balance sheet runs above 150 times its market cap is left out for the same reason.
  • Market cap: stated at each company's latest close, which is newer than the annual figure ranked here.
  • Update cadence: refreshed as companies file new annual reports (typically within 60–90 days of fiscal year end).

Not financial advice. This is a research tool, not a recommendation.

Frequently asked questions

Why does R&D spending vary so widely across healthcare subsectors?

The activities differ fundamentally. Large pharma funds long clinical programs across multiple therapeutic areas, so spending scales with pipeline breadth. Biotech developers without approved products often spend most of their capital on one or two programs, making R&D the dominant expense line and cash burn the central metric. Medical device firms run shorter, cheaper studies, and managed-care organizations barely report R&D at all because their business is insurance risk rather than product discovery.

Do high R&D costs guarantee drug approvals or future revenue?

No. Clinical development carries a high attrition rate, and even late-stage programs fail for efficacy, safety, or commercial reasons. Spending tells you a firm is committed to the pipeline, not that the pipeline will convert. The composition of R&D matters more than the total: the number of late-stage assets, diversity of mechanism, and strength of prior readouts give a better signal about future earnings potential than the dollar figure in isolation.

How should investors think about R&D at a biotech with no products approved?

At developmental biotech, R&D essentially is the business and the reported loss equals the cost of discovering tomorrow's revenue. The question shifts from profitability to runway: how many quarters of current cash position fund the planned program, when do key data readouts arrive, and whether dilution from future financings is priced in. R&D paired with cash on the balance sheet and projected burn gives a clearer view of financial durability than the income statement alone.